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Representing Topic-Comment Structures in Chinese
( Haihua Pan ),( Jianhua Hu ) 한국언어정보학회 2002 국제 워크샵 Vol.2002 No.-
Shi (2000) claims that topics must be related to a syntactic position in the comment, thus denying the existence of dangling topics in Chinese. Under Shi``s analysis, the dangling topic sentences in Chinese are not topic-comment but subject-predicate sentences. However, Shi``s arguments are not without problems. In this paper we argue that topics in Chinese can be licensed not only by a syntactic gap but also by a semantic gap/variable without syntactic realization. Under our analysis, all the dangling topics discussed in Shi (2000) are, in fact, not subjects but topics licensed by a semantic gap/variable that can turn the relevant comment into an open predicate, thus licensing dangling topics and deriving well-formed topic-comment constructions. Our analysis fares better than Shi``s in not only unifying the licensing mechanism of a topic to an open predicate without considering how the open predicate is derived, but also unifying the treatment of normal and dangling topics in Chinese.
Comparison of the main compounds in Fuding white tea infusions from various tea types
Junxian Pan,Yulan Jiang,Yangjun Lv,Man Li,Shikang Zhang,Jun Liu,Yuejin Zhu,Haihua Zhang 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.5
The purpose of this study was to compare the main components, and particularly catechins, caffeine, theanine, free amino acids, and water extracts, in Bai Hao Yin Zhen, Bai Mu Dan, and Shou Mei Fuding white tea infusions brewed at different temperatures, and their contributions to taste were estimated by dose-over-threshold value. Infusion temperature had a distinct effect on the main components extracted, and 100 C was found to be optimal for extracting catechins and caffeine. However, the effect of temperature on theanine, free amino acids, and water extracts varied with tea type. Bai Mu Dan and Shou Mei yielded a higher content of the major compounds than did Bai Hao Yin Zhen. Thus, infusion temperature had a large effect on extracting the main compounds, and the differences in content between the three white teas presumably reflected differences in the harvest time, processing method or leaf shape.
MicroRNA-206 Protects against Myocardial Ischaemia-Reperfusion Injury in Rats by Targeting Gadd45β
Zhai, Changlin,Qian, Qang,Tang, Guanmin,Han, Bingjiang,Hu, Huilin,Yin, Dong,Pan, Haihua,Zhang, Song Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.12
MicroRNAs are widely involved in the pathogenesis of cardiovascular diseases through regulating gene expression via translational inhibition or degradation of their target mRNAs. Recent studies have indicated a critical role of microRNA-206 in myocardial ischaemia-reperfusion (I/R) injury. However, the function of miR-206 in myocardial I/R injury is currently unclear. The present study was aimed to identify the specific role of miR-206 in myocardial I/R injury and explore the underlying molecular mechanism. Our results revealed that the expression level of miR-206 was significantly decreased both in rat I/R group and H9c2 cells subjected to hypoxia/reoxygenation (H/R) compared with the corresponding control. Overexpression of miR-206 observably decreased infarct size and inhibited the cardiomyocyte apoptosis induced by I/R injury. Furthermore, bioinformatics analysis, luciferase activity and western blot assay proved that $Gadd45{\beta}$ (growth arrest DNA damage-inducible gene $45{\beta}$) was a direct target gene of miR-206. In addition, the expression of pro-apoptotic-related genes, such as p53, Bax and cleaved caspase3, was decreased in association with the down-regulation of $Gadd45{\beta}$. In summary, this study demonstrates that miR-206 could protect against myocardial I/R injury by targeting $Gadd45{\beta}$.
MicroRNA-206 Protects against Myocardial Ischaemia-Reperfusion Injury in Rats by Targeting Gadd45β
Changlin Zhai,Qang Qian,Guanmin Tang,Bingjiang Han,Huilin Hu,Dong Yin,Haihua Pan,Song Zhang 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.12
MicroRNAs are widely involved in the pathogenesis of cardiovascular diseases through regulating gene expression via translational inhibition or degradation of their target mRNAs. Recent studies have indicated a critical role of microRNA-206 in myocardial ischaemia-reperfusion (I/R) injury. However, the function of miR-206 in myocardial I/R injury is currently un-clear. The present study was aimed to identify the specific role of miR-206 in myocardial I/R injury and explore the underlying molecular mechanism. Our results revealed that the expres-sion level of miR-206 was significantly decreased both in rat I/R group and H9c2 cells subjected to hypoxia/reoxygenation (H/R) compared with the corresponding control. Overexpression of miR-206 observably decreased infarct size and inhibited the cardiomyocyte apoptosis induced by I/R injury. Furthermore, bioinformatics analysis, luciferase activity and western blot assay proved that Gadd45beta (growth arrest DNA damage-inducible gene 45beta) was a direct target gene of miR-206. In addition, the expression of pro-apoptotic-related genes, such as p53, Bax and cleaved caspase3, was decreased in association with the down-regulation of Gadd45beta. In summary, this study demonstrates that miR-206 could protect against myocardial I/R injury by targeting Gadd45beta.