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- 저자 : ( Haeng Mook Cho ) (검색결과 2 건)
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Amyloid β‐induced elevation of O‐GlcNAcylated c‐Fos promotes neuronal cell death
Choi, Heesun,Kim, Chaeyoung,Song, Hyundong,Cha, Moon‐,Yong,Cho, Hyun Jin,Son, Sung Min,Kim, Haeng Jun,Mook‐,Jung, Inhee BLACKWELL PUBLISHING 2019 Aging Cell Vol.18 No.1
<P><B>Abstract</B></P><P>Alzheimer's disease (AD) is an age‐related neurodegenerative disease characterized by progressive memory loss resulting from cumulative neuronal cell death. O‐linked β‐N‐acetyl glucosamine (O‐GlcNAc) modification of the proteins reflecting glucose metabolism is altered in the brains of patients with AD. However, the link between altered O‐GlcNAc modification and neuronal cell death in AD is poorly understood. Here, we examined the regulation of O‐GlcNAcylation of c‐Fos and the effects of O‐GlcNAcylated c‐Fos on neuronal cell death during AD pathogenesis. We found that amyloid beta (Aβ)‐induced O‐GlcNAcylation on serine‐56 and 57 of c‐Fos was resulted from decreased interaction between c‐Fos and O‐GlcNAcase and promoted neuronal cell death. O‐GlcNAcylated c‐Fos increased its stability and potentiated the transcriptional activity through higher interaction with c‐Jun, resulting in induction of Bim expression leading to neuronal cell death. Taken together, Aβ‐induced O‐GlcNAcylation of c‐Fos plays an important role in neuronal cell death during the pathogenesis of AD.</P>
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Effect of Mixing Ratio of Biodiesel on Breakup Characteristics of a Single Droplet
( Yop Kim Sa ),( Sung Wook Park ),( Kian Sung ),( Haeng Mook Cho ),( Chang Sik Lee ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
In this paper, the breakup characteristics of a single droplet were analyzed as a function of mixing ratio of bioidesel. In order to investigate the effects of high surface tension and viscosity of biodiesel on the breakup mechanism of single droplet, the experiments were performed at various mixing ratios of biodiesels. In addition, the physical properties such as density, kinematic viscosity and surface tension of the biodiesel blended fuels were measured to study the relations between the non-dimensional numbers such as Weber number and Reynolds number, and the breakup mechanism. The experimental apparatus consisted of a droplet generation system, an air flow nozzle, a light source, a long distance microscope and a CCD camera. In the first stage breakup region, the droplet deformation rate was measured in order to reveal out the effect of high surface tension and kinematic viscosity on the deformation of a single droplet. The results of this experiment showed that the higher surface tension and viscosity of biodiesel prevent the disintegration of liquid droplet. Also the breakup mechanism is transited at higher relative velocity as the mixing ratio is increased.
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