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A rare tumor : gastrointestinal stromal tumor in the rectovaginal septum
( Ey Hur ),( Yh Lee ),( Go Chong ),( Dg Hong ),( Yl Cho ),( Is Park ),( Ys Lee ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Objective: To describe a case of gastrointestinal stromal tumor (GIST) outside gastrointestinal tract and arising in the recovaginal septum. Case A 54-year-old woman presented protruding large vaginal mass. The mass adhered with posterior vaginal wall but did not invade rectum. Total abdominal hysterectomy, bilateral salpingooophorectomy and lower anterior resection of rectum with end to end anastomosis were performed. Pathologically the tumor consisted of spindle cells of high cellular density and focal necrosis with the mitotic count being 4-5 mitoses per 50 high-power fields. On immunohistochemical evaluation, the tumor cell express strong and diffuse staining for c-kit, P53, S-100 and P16, and the tumor cells showed no staining with SMA. After surgery, the patient received imatinib (Glivec). Conclusions Until now, only 11 cases of GIST arising in rectovaginal septum have been research in Pubmed. Complete excision with free margin and use of imatinib are treatment of choice. With literature review late recurrences occurred. Long term follow up is necessary. Gynecologist should be consider GIST in the evaluation of a mass arising in the rectovaginal septum.
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