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신고리 지역 기상관측을 통한 계절별 대기안정도 특성분석
송상근,김유근,오인보,정주희,조윤미,우경은,강태훈 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-
In this study, we analyzed the characteristics of atmospheric stability to investigate local environment change at an atomic power plant in Gori region. The used data was obtained from field observation of major meteorological variables such as wind direction and speed, air temperature, relative humidity, and solar radiation using AWS (Automatic Weather System) in Gori region from February to September in 2003. As a result, when strong northerly winds (more than 4~6 m/s) and weak northwesterly winds (2~3m/s) blow, atmospheric stability was neutral and stable from winter to spring, respectively. Atmospheric stability (neutral) in summer was similar to that in two other seasons (winter and spring), but it was stable for weak southwesterly winds (2~3 m/s). Finally, atmospheric stability was neutral for strong winds (over 4~6 m/s) in fall without respect to wind direction, while that was stable for very weak winds (less than 2 m/s).
외상간호교육 요구분석 : 권역외상센터 간호사를 대상으로
조순영 ( Joe Seun-young ),서유미 ( Seo You-mi ),정은경 ( Jeong Eun-kyoung ),최주영 ( Choi Ju-young ) 국군간호사관학교 군진간호연구소 2016 군진간호연구 Vol.34 No.2
Purpose : This study analyzes the completion level of the trauma nursing education courses and the educational needs for nurses working at the regional trauma centers. Methods : The study used triangulation method. To develop questionnaires, Focus group interviews with nurses from 3 trauma centers followed by Colaizzi`s phenomenological methodology were conducted. 228 nurses working at 5 trauma centers were recruited to participate in a self-administered survey. Data were analyzed using descriptive statistics for the completion level of trauma nursing, importance of trauma nursing education course & performance frequency. Paired t-test was used to compare deference between the importance of trauma nursing education course & performance frequency. Results : Only 28.9% of trauma nurses have completed the trauma nursing education courses. By the survey, each of the importance scale about nursing task in trauma center scored on average 4.13±0.82(Likert 5 scale). Especially, shock patient nursing scored the highest importance nursing task, followed by airway and ventilation, thoracic and neck trauma nursing. Among 41 trauma nursing educational section, 40 subjects had significant difference between the importance and frequency. Furthermore, the study analyzed that there is a high demand on education about the most recent trends related to trauma and the equipments. Conclusion : The study indicated needs to establish requirements as trauma nurses and reexamine trauma nursing competency. In addition, standardized trauma nursing education courses needs to be developed reflecting educational needs and frequently performed skills in clinical area.
Kim, Kyoung-Han,Kim, Yun Hye,Son, Joe Eun,Lee, Ju Hee,Kim, Sarah,Choe, Min Seon,Moon, Joon Ho,Zhong, Jian,Fu, Kiya,Lenglin, Florine,Yoo, Jeong-Ah,Bilan, Philip J,Klip, Amira,Nagy, Andras,Kim, Jae-Ryon Nature Publishing Group 2017 Cell research Vol.27 No.11
<P>Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT). Furthermore, periodic adipose-VEGF overexpression could recapitulate the metabolic improvement of IF in non-fasted animals. Importantly, fasting and adipose-VEGF induce alternative activation of adipose macrophage, which is critical for thermogenesis. Human adipose gene analysis further revealed a positive correlation of adipose VEGF-M2 macrophage-WAT browning axis. The present study uncovers the molecular mechanism of IF-mediated metabolic benefit and suggests that isocaloric IF can be a preventive and therapeutic approach against obesity and metabolic disorders.</P>
Overexpression of $AMPK{\alpha}1$ Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats
Seo, Eun-Hui,Park, Eun-Jin,Joe, Yeon-Soo,Kang, Soo-Jeong,Kim, Mi-Sun,Hong, Sook-Hee,Park, Mi-Kyoung,Kim, Duk-Kyu,Koh, Hyong-Jong,Lee, Hye-Jeong The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.6
5'-AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic ($\alpha$) and two regulatory ($\beta$ and $\gamma$) subunits. Two isoforms are known for catalytic subunit (${\alpha}1$, ${\alpha}2$) and are encoded by different genes. To assess the metabolic effects of $AMPK{\alpha}1$, we examined the effects of overexpression of adenoviral-mediated $AMPK{\alpha}1$ in hyperlipidemic type 2 diabetic rats. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an established animal model of type 2 diabetes that exhibits chronic and slowly progressive hyperglycemia and hyperlipidemia. Thirty five-week-old overt type 2 diabetic rats (n=10) were administered intravenously with Ad.$AMPK{\alpha}1$. AMPK activity was measured by phosphorylation of acetyl CoA carboxlyase (ACC). To investigate the changes of gene expression related glucose and lipid metabolism, quantitative real-time PCR was performed with liver tissues. Overexpression of $AMPK{\alpha}1$ showed that blood glucose concentration was decreased but that glucose tolerance was not completely recovered on 7th day after treatment. Plasma triglyceride concentration was decreased slightly, and hepatic triglyceride content was markedly reduced by decreasing expression of hepatic lipogenic genes. Overexpression of $AMPK{\alpha}1$ markedly improved hepatic steatosis and it may have effective role for improving hepatic lipid metabolism in hyperlipidemic state.
Overexpression of AMPKՁ1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats
Eunhui Seo,Eun-Jin Park,Yeonsoo Joe,Soojeong Kang,Mi-Sun Kim,Sook-Hee Hong,Mi-Kyoung Park,Duk Kyu Kim,Hyongjong Koh,Hye-Jeong Lee 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.6
5 -AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic (Ձ) and two regulatory (Ղ and Ճ) subunits. Two isoforms are known for catalytic subunit (Ձ1, Ձ2) and are encoded by different genes. To assess the metabolic effects of AMPKՁ1, we examined the effects of overexpression of adenoviral-mediated AMPKՁ1 in hyperlipidemic type 2 diabetic rats. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an established animal model of type 2 diabetes that exhibits chronic and slowly progressive hyperglycemia and hyperlipidemia. Thirty five-week-old overt type 2 diabetic rats (n=10) were administered intravenously with Ad.AMPKՁ1. AMPK activity was measured by phosphorylation of acetyl CoA carboxlyase (ACC). To investigate the changes of gene expression related glucose and lipid metabolism, quantitative real-time PCR was performed with liver tissues. Overexpression of AMPKՁ1 showed that blood glucose concentration was decreased but that glucose tolerance was not completely recovered on 7th day after treatment. Plasma triglyceride concentration was decreased slightly, and hepatic triglyceride content was markedly reduced by decreasing expression of hepatic lipogenic genes. Overexpression of AMPKՁ1 markedly improved hepatic steatosis and it may have effective role for improving hepatic lipid metabolism in hyperlipidemic state.
PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death
Choi, Hyo-Kyoung,Choi, Youngsok,Kang, HeeBum,Lim, Eun-jin,Park, Soo-Yeon,Lee, Hyun-Seob,Park, Ji-Min,Moon, Jisook,Kim, Yoon-Jung,Choi, Insup,Joe, Eun-Hye,Choi, Kyung-Chul,Yoon, Ho-Geun IRL Press 2015 Human molecular genetics Vol.24 No.4
<P>Deciphering the molecular basis of neuronal cell death is a central issue in the etiology of neurodegenerative diseases, such as Parkinson's and Alzheimer's. Dysregulation of p53 levels has been implicated in neuronal apoptosis. The role of histone deacetylase 3 (HDAC3) in suppressing p53-dependent apoptosis has been recently emphasized; however, the molecular basis of modulation of p53 function by HDAC3 remains unclear. Here we show that PTEN-induced putative kinase 1 (<I>PINK1</I>), which is linked to autosomal recessive early-onset familial Parkinson's disease, phosphorylates HDAC3 at Ser-424 to enhance its HDAC activity in a neural cell-specific manner. PINK1 prevents H<SUB>2</SUB>O<SUB>2</SUB>-induced C-terminal cleavage of HDAC3 via phosphorylation of HDAC3 at Ser-424, which is reversed by protein phosphatase 4c. PINK1-mediated phosphorylation of HDAC3 enhances its direct association with p53 and causes subsequent hypoacetylation of p53. Genetic deletion of PINK1 partly impaired the suppressive role of HDAC3 in regulating p53 acetylation and transcriptional activity. However, depletion of HDAC3 fully abolished the PINK1-mediated p53 inhibitory loop. Finally, ectopic expression of phosphomometic-HDAC3<SUP>S424E</SUP> substantially overcomes the defective action of PINK1 against oxidative stress in dopaminergic neuronal cells. Together, our results uncovered a mechanism by which PINK1–HDAC3 network mediates p53 inhibitory loop in response to oxidative stress-induced damage.</P>