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( Edyta M. Grzelak ),( Changhwa Hwang ),( Geping Cai ),( Joo Won Nam ),( Mary P Choules ),( Wei Gao ),( David C Lankin ),( James B Mcalpine ),( Surafel G Mulugeta ),( Jose G Napolitano ),( Joo Won Suh 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
While natural products constitute an established source of lead compounds, the classical iterative bioassay-guided isolation process is both time- and labor-intensive and prone to failing to identify active minor constituents. (HP)TLC.bioautography.MS/NMR, which combines cutting-edge microbiological, chromatographic, and spectrometric technologies, was developed 10 accelerate anti-tuberculosis (TB) drug discovery from natural sources by acquiring structural information at a very early stage of the isolation process, Using the avirulent, bioluminescent Mtb strain mc<sup>2</sup>7000 luxABCDE, three variations of bioautography were evaluated and optimized for sensitivity in detecting anti-T``B agent , including established clinical agents and new lead with novel mechanisms of action. Several exemplary applications of this approach to microbial extracts demonstrate its potential as a routine method in anti-TB drug discovery from natural sources.