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Clinical Features and Surgical Results of Brain Abscesses
Park, Dae-Hee,Lee, Sang-Hoon,Lee, Kyoung-Soo,Chung, Ui-Wha,Park, Kang-Hwa,Lee, Young-Woo The Korean Neurosurgical Society 2005 Journal of Korean neurosurgical society Vol.37 No.4
Objective: This study is undertaken to review the characteristics, risk factors and the surgical outcomes in long term follow-up of brain abscesses. Methods: We had reviewed medical records and radiological findings in patients with brain abscess who underwent operations in our hospital from January 1992 to June 2003. Results: Observed 11 cases were comprised of 8 men and 3 women with 42 years old average age ranging from 17 to 66. Lesions were located at frontal lobe in 5 cases, parietal in 4 cases, temporal in 1 case, and occipital in 1 case. The mean follow-up period was 23.8 months and ranged from 5 to 33 months. The microbial sources of infection had been found in 5 cases (45%). The organisms were identified by using the microbial culture obtained from the excisional biopsy. We had applied all cases with surgical excision. Empirical antibiotic treatment started soon after diagnosis in all cases. The mortality and morbidity of surgical excision were low. Nine patients were neurologically improved. One patient had died after the operation due to acute respiratory distress syndrome (ARDS). Conclusion: The single and large abscess located in an accessible lesion is a good candidate for surgical excision because of it's low morbidity, mortality, and favorable outcome after surgical excision. Further study is required to compare the surgical excision with other treatment modalities of brain abscess.
Biological Object Downloader (BOD) Service for Easy Download and Management of Biological Databases
Park, Dae-Ui,Lee, Jung-Woo,Yoon, Gi-Seok,Gong, Sung-Sam,Bhak, Jong Korea Genome Organization 2007 Genomics & informatics Vol.5 No.4
BOD is an FTP service management tool on the Internet. It was developed for biological researchers in South Korea. It enables easier and faster access of bioinformation without having to go through foreign FTP sites. BOD includes an automatic downloader with a management and email alert service from which the user can easily select and schedule any biological database. Once listed in BOD, the user can check and modify the download status and data from an additional email alert service.
Park, Min Ui,Lee, Seong Min,Chung, Dae-won Elsevier 2019 Synthetic metals Vol.258 No.-
<P><B>Abstract</B></P> <P>We herein report a synthetic route to electro-conductive films with enhanced water stability involving cross-linking poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) with bisphenol A diglycidyl ether (DGEBA). The reaction was confirmed by Fourier-transform infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS) analyses. Furthermore, evaluation of the surface resistance, transmittance and roughness of the films was also conducted. As a consequence of quantitative analysis of the water stability of the films by measurement of the surface resistance, as well as transmittance of the films after immersion in buffer solution (pH = 7.4), it was determined that the PEDOT:PSS film with 0.5% DGEBA displayed a remarkable improvement in water resistance without any reduction in the initial electrical properties and transmittance of the films. The PEDOT:PSS film, which was reacted with DGEBA also exhibited significant improvement in thermal stability at 180 °C. Our study proposes a promising method for development of an electrode applicable to biological environments, where contact with water is often unavoidable.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We prepared electro-conductive films displaying enhanced water-stability by cross-linking PEDOT:PSS with bisphenol A diglycidyl ether (DGEBA). </LI> <LI> Cross-linking reaction was confirmed by FT-IR and XPS studies. </LI> <LI> Water-stability of the films was quantitatively evaluated by measuring the surface resistance of the films after immersing in buffer solution. </LI> <LI> PEDOT:PSS films that have reacted with DGEBA displayed a remarkable improvement in water resistance and thermal stability. </LI> </UL> </P>
Structural Bioinformatics Analysis of Disease-related Mutations
Park, Seong-Jin,Oh, Sang-Ho,Park, Dae-Ui,Bhak, Jong Korea Genome Organization 2008 Genomics & informatics Vol.6 No.3
In order to understand the protein functions that are related to disease, it is important to detect the correlation between amino acid mutations and disease. Many mutation studies about disease-related proteins have been carried out through molecular biology techniques, such as vector design, protein engineering, and protein crystallization. However, experimental protein mutation studies are time-consuming, be it in vivo or in vitro. We therefore performed a bioinformatic analysis of known disease-related mutations and their protein structure changes in order to analyze the correlation between mutation and disease. For this study, we selected 111 diseases that were related to 175 proteins from the PDB database and 710 mutations that were found in the protein structures. The mutations were acquired from the Human Gene Mutation Database (HGMD). We selected point mutations, excluding only insertions or deletions, for detecting structural changes. To detect a structural change by mutation, we analyzed not only the structural properties (distance of pocket and mutation, pocket size, surface size, and stability), but also the physico-chemical properties (weight, instability, isoelectric point (IEP), and GRAVY score) for the 710 mutations. We detected that the distance between the pocket and disease-related mutation lay within $20\;{\AA}$ (98.5%, 700 proteins). We found that there was no significant correlation between structural stability and disease-causing mutations or between hydrophobicity changes and critical mutations. For large-scale mutational analysis of disease-causing mutations, our bioinformatics approach, using 710 structural mutations, called "Structural Mutatomics," can help researchers to detect disease-specific mutations and to understand the biological functions of disease-related proteins.
Dae Hee Lee,Jae Suk Park,Ui Joon Lee,Mi Ra Ryu,Tae Jin Kim 한국자동차공학회 2011 한국자동차공학회 지부 학술대회 논문집 Vol.2011 No.10-2
A highly efficient low-emission co-generation system using a 2000-cc common-rail direct-injection (CRDI) diesel engine with an after-treatment device (re-combustor) was developed. The co-generation concept was utilized to produce electric power by a generator as well as to recover waste heat from the exhaust gases. A re-combustor was installed at the exhaust gas outlet to perform secondary burning of the exhaust gases, resulting in an improvement of the system’s thermal efficiency as well as a reduction of exhaust gas emissions. The main components of the re-combustor were coiled Nichrome wires installed in a ceramic housing, a diesel oxidation catalyst (DOC), and a diesel particulate filter (DPF). The tests were conducted at four water flow rates (10, 15, 20, and 25 LPM) and four electric power outputs (5, 15, 25, and 35 kW). In general, a great deal of time and expense are required to determine the optimum experimental conditions for the maximum efficiency of a co-generation system. However, in the present study, relationships between experimental conditions were derived by performing only a minimal number of experiments, applying a method based on Taguchi design and analysis of variance (ANOVA). The results show that at a water flow rate of 20 LPM, an electric load of 25 kW, and a ceramic heater input of 4 kW, the system achieved a maximum total efficiency of 85.7%.
Hemodynamic Response of Young Smokers to Induction and Intubation
( Dae Lim Jee ),( Ui Kyun Park ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.50 No.6
Background: To test whether smokers have exaggerated hemodynamic responses to induction and intubation, we investigated the changes in blood pressure (BP) and heart rate (HR) on induction and intubation in smokers and nonsmokers. Methods: Healthy male patients (25 smokers and 25 nonsmokers, aged 20 to 29 yrs) for elective surgery were studied. Anesthesia was induced with thiopental 3 mg/kg, fentanyl 1.5μg/kg, vecuronium 0.1 mg/kg and maintained with enflurane 1 % in N2O and O2 for the period of observation. After three minutes, orotracheal intubation was performed. Noninvasive BP and HR were recorded one minute before induction (baseline), immediately before intubation, and then every minute until five minutes after intubation. Results: Systolic BP of smokers decreased significantly immediately before intubation, and at 4 and 5 min after intubation as compared to that of nonsmokers (Mean ± SEM, 120.8 ± 3.0 vs. 109.9 ± 2.8, 116.7 ± 2.4 vs. 108.9 ± 2.3, and 114.8 ± 2.2 vs. 106.7 ± 2.3 mmHg, respectively, P < 0.05). Diastolic BP of smokers decreased only immediately before intubation compared with that of nonsmokers (Mean ± SEM, nonsmoker 64.6 ± 2.4 vs. smoker 58.6 ± 1.8 mmHg, P < 0.05). However, there was no significant difference of HR between smokers and nonsmokers during the observational period. Conclusions: Hemodynamic response is different in smokers compared with nonsmokers. Our results indicate that smoking affects the hemodynamic response to induction and intubation. (Korean J Anesthesiol 2006; 50: S 14~8)
박의열,김채영,윤대원 경북대학교 전자기술연구소 1980 電子技術硏究誌 Vol.1 No.1
A trial to establish a LCR meter based on the theory of cancellation of the imaginary current for the LCR series circuit was investigated for the domestic technical study. Its typical values of the passive elements were measured and compared with the calculated values, which showed a fair agreement and discussed some technical points.