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ISONIAZID 대량투여에 의한 백서간의 조직 병리학적 연구
이충식 충남대학교 의과대학 지역사회의학연구소 1980 충남의대잡지 Vol.7 No.2
Isoniazid, a widely used antituberculous drug, were oxidized by cytochrome p450 enzymes in human and rat liver microsomes to highly reactive acylating and alkylating agents, and this process were potentiated by pretreatment with phenobarbital. To evaluate the histopathological changes for the influences of isoniazid treatment and phenobarbital pretreatment, each intraperitoneal injections of physiologic saline solution, 100mg of phenobarbital, or 200mg of phenobarbital were given to male albino rats, and then each 500mg/kg of isoniazid in physiologic saline solution also were given intraperitoneally. The results obtained were as follows: 1. The mortality in isoniazid only treated rats was 0%, in phenobarbital 100mg pretretaed rats was 0%, and in phenobarbital 200mg pretreated rats was 25%. 2. The hepatic cellular necrosis in isoniazid only treated rats was mild on-the 2nd day of experiment, whereas phenobarbital 100mg pretreated rats was mild on the 3rd day and moderately progressed on the 6th day. The phenobarbital 200mg pretreated rats revealed moderate necrotic change after the 2nd day of experiment. 3. On reticular staining, derangement of reticular fibers in isoniazid only treated rats was also mild on the 2nd day of experiment. The phenobarbital 100mg pretreated rats were noted mildly on the 3rd day of experiment, but intensively changed after the 5th day, compared with marked irregularity after the 2nd day in 200mg pretreated rats.
Gd₂(MoO₄)₃ 단결정의 강탄성 Switching력에 관한 연구
이수대,설정식 慶南大學校 附設 基礎科學硏究所 1996 硏究論文集 Vol.8 No.-
In this study, we derived the formulae about enthalpy density per unit force when occured ferroelastic switching. The enthalpy contour lines were calculated from the spontaneous strain tensor and these formulae when was switched from a S₁ferroelastic state to a S₂ferroelastic state. The magnitude and the direction of minimum stress were estimated at the distribution charts of enthalpy density per unit force when was switched from a S₁state to a S₂state and we experimented on these phenomena. The direction that occur the switching phenomenon by the least compression force was the [110] direction when was switched from a S₁state to a S₂state and the switching force was between 60 N/㎠ and 70N/㎠ . Measured, the spontaneous strain tensor, e?? of Gd₂(MoO₄)₃single crystal from strain by the switching phenomenon was 1.57×10??.
한국 재원 정신분열병환자의 사회경제적 특성에 관한 역학적 조사 : 일일 시정조사 Point Prevalence Study
정인원,김용식,이정균 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1
1984년 2월 27일 현재 전국 정신과 병·의원의 입원환자를 대상으로 일일시정조사를 시행하였다. 자료분석 때까지 도착한 자료중 ICD-9의 진단기준에 의하여 정신질환의 범주에 속하는 2,895명을 1:1 쌍쌍대응법으로 분석하여 거주지별로 정신분열병군과 대조군간의 사회경제적 특성을 비교하였다. 분석결과는 다음과 같았다. 1. 정신분열병환자의 결혼상태는 두 지역 모두에서 독신이 많았고 odd ratio는 각각 5.33과 3.56이었다. 농ㆍ어촌의 정신분열병환자가 독신이 더 많았다. 2. 교육수준은 양 군에서 뚜렷한 차이는 없었다. 3. 직업은 도시의 정신분열병환자에서 무직이 많았고 odd ratio는 1.90이었다. 4. 경제수준은 도시의 정신분열병환자에서 낮은 층이 많았고 odd ratio는 1.65이었다. 5. 그외 가족구조와 종교, 부모의 결혼상태에서는 유의한 차이를 보이지 않았다. Aiming at suggestion the possible ways to improve psychiatric care, rehabilitation, and mental health services in Korea, this nation-wide hospital study was intended to explore the socioeconomical status of mental in-patients. This point prevalence study was conducted to patients who were in psychiatric wards at Feb. 27th. 1984 using mailing questionnaire. The number of hospitals and clinics answered was 88 and the patients, 3,300. Among them, we selected the 2,895 patients who were included in mental disorders (290-319) by ICD-9. Finally we compared the socioeconomical status between schizophrenia and non-schizophrenia in rural and urban area with the method of Fleiss. The results were as follows; 1. The relative proportions of single persons in schizophrenia were higher in both areas, and their odds ratios were 5.33 and 3.56, respectively. There were more single schizophrenics in rural than urban. 2. In educational levels, there were no significant differences between schizophrenia and control. 3. In urban area, the jobless persons were more in schizophrenia than control, and its odd ratio was 1.90. 4. The urban schizophrenics were significantly lower than the urban control in economical levels, and its odd ratio was 1.65. 5. About family structure, religion, and marital status of parents, there were no significant differences between schizophrenia and control.
이경수,서정식 영남이공대학 산업기술연구소 2002 産業技術硏究 Vol.14 No.-
The effects of chitosan treatments on the shelf-life of wet noodles during storage at 18℃ for 9 days were investigated. During storage, moisture contents of the control and chitosan treatment groups increased. The numbers of total viable cells decreased through chitosan treatment, then shelf life of wet noodles by chitosan treatment prolonged more than 3 days. The sensory scores were high on wet noodles(Ⅱ) and (Ⅲ).
이수대,채건식,김영국,설정식 慶南大學校 附設 基礎科學硏究所 1989 硏究論文集 Vol.1 No.-
The temperature dependence of the ultrasonic velocity of 10 MHz and the absorption coefficient in the 10-30MHz range by the pulse echo method were determined in lead germanate single crystal. The velocity of longitudinal 10 MHz ultrasound along the c axis changed anomalously at the phase transition point and the jump was approximately 50m/sec. Near Curie point, the relaxation time and the kinetic coefficient of electric polarization from the Landau-Khalatnikov theory were calculated as ?? sec and ??, respectively. At room temperature, the viscosity tensor were measured as, ?? in the MKS units.
이수대,설정식 慶南大學校 附設 基礎科學硏究所 1995 硏究論文集 Vol.7 No.-
The impedance and ac conductivity of K(Nb₁-xVx)O₃ are measured by the low frequency impedance analyzer. Ac conductivity depends on the temperature and the frequency. As we substitute V5+ ions more, the phase transition points increase, and the Curie temperature move to higher temperatures. Temperature dependence of the conductivity beleow 10.6Hz can be interpreted as a hopping conduction by charged particles, and that over 10.7 Hz which is nearly independent of the temperature and can be explained as a hopping conduction among impurieties.
이수대,설정식,오상범 慶南大學校 附設 基礎科學硏究所 1991 硏究論文集 Vol.3 No.-
We measured the thermal expansion coefficient, the variation of refractivity and the stress-optical coefficient of the Bi₁₂SiO?? single crystal by the Mach-Zehnder interferometer. The thermal expansion coefficient of the Bi₁₂SiO? single crystal was 9×10?? /℃ at the near room temperature and 1×10?? /℃ at the near 200℃. The refractivity of the Bi₁₂SiO?? single crystal that was measured from the Brewster angle at the room temperature was 2.540. The stress optical coefficient q₁₃ was 6.6×10?? m²/N at the room temperature.