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Lattice Relations and Solidification of the Complex Regular Eutectic (Cr,Fe)-(Cr,Fe)23C6
Hsuan-Han Lai,Chih-Chun Hsieh,Chi-Ming Lin,Weite Wu 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.3
The eutectic (Cr,Fe)-(Cr,Fe)23C6 showed a triaxial fishbone structure and could be categorized as a “complexregular structure”. In this study, the lattice relations of the fishbone (Cr,Fe)23C6 were examined and the solidificationprocess was observed using a transmission electron microscope and a confocal laser scanning microscope. Forone of the three fish bones in a eutectic cell, parallel (Cr,Fe)23C6 lamellas at one side of the spine had the samelattice direction, as did those in the (Cr,Fe) phase. The lattices of neighboring (Cr,Fe)23C6 and (Cr,Fe) phases werenot coherent. Lamellar (Cr,Fe)23C6 on opposite sides of a spine had different lattice directions, and their latticeboundary was in the spine. By using the confocal laser scanning microscope, the solidification of lamellar eutecticstructure could be observed. At the low cooling rate of 5oC·min-1, parallel lamellas would grow thick blocksinstead of thin plates. To obtain a thin lamellar eutectic structure, the cooling rate should be higher, likethe rate in welding.
Lin Chih-Hsin,Hsieh Yu-Shao,Sun Ying-Chieh,Huang Wun-Han,Chen Shu-Ling,Weng Zheng-Kui,Lin Te-Hsien,Wu Yih-Ru,Chang Kuo-Hsuan,Huang Hei-Jen,Lee Guan-Chiun,Hsieh-Li Hsiu Mei,Lee-Chen Guey-Jen 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.1
Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual screening was performed to search database for compounds targeting GSK-3β from Enamine’s screening collection. Of the top-ranked compounds, 7 primary hits underwent a luminescent kinase assay and a cell assay using human neuroblastoma SH-SY5Y cells expressing Tau repeat domain (TauRD) with pro-aggregant mutation ΔK280. In the kinase assay for these 7 compounds, residual GSK-3β activities ranged from 36.1% to 90.0% were detected at the IC50 of SB-216763. In the cell assay, only compounds VB-030 and VB-037 reduced Tau aggregation in SH-SY5Y cells expressing ΔK280 TauRD-DsRed folding reporter. In SH-SY5Y cells expressing ΔK280 TauRD, neither VB-030 nor VB-037 increased expression of GSK-3α Ser21 or GSK-3β Ser9. Among extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT), mitogen-activated protein kinase 14 (P38) and mitogenactivated protein kinase 8 (JNK) which modulate Tau phosphorylation, VB-037 attenuated active phosphorylation of P38 Thr180/ Tyr182, whereas VB-030 had no effect on the phosphorylation status of ERK, AKT, P38 or JNK. However, both VB-030 and VB-037 reduced endogenous Tau phosphorylation at Ser202, Thr231, Ser396 and Ser404 in neuronally differentiated SH-SY5Y expressing ΔK280 TauRD. In addition, VB-030 and VB-037 further improved neuronal survival and/or neurite length and branch in mouse hippocampal primary culture under Tau cytotoxicity. Overall, through inhibiting GSK-3β kinase activity and/or p-P38 (Thr180/Tyr182), both compounds may serve as promising candidates to reduce Tau aggregation/cytotoxicity for AD treatment.
Hsuan-Han Lai,Chih-Chun Hsieh,Chi-Ming Lin,Weite Wu 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.1
In this study, the effects of vanadium on the morphology and wear behavior of a eutectic Cr-Fe-C hardfacing alloy were discussed. The alloys tested contained different amounts of vanadium, ranging from 0 to 2.39 wt%. A fibrous V4C3 was found when the alloy contained 0.93 wt% vanadium. The addition of vanadium was found to decrease the fraction of eutectic M23C6 and increase the width of the interspaces between the eutectic cells. The DTA results revealed that V4C3 formed just before the eutectic α+M23C6 during solidification. The surface hardness was shown to increase with increasing vanadium content, which also caused the hardness deviation and wear loss to decrease; however, the addition of vanadium was not shown to affect the hardness of eutectic α+M23C6. The V4C3 could be scratched off during the wear test due to the increase in the width of the interspaces between the eutectic cells; therefore, the alloys that contained 0.93 and 2.39 wt% vanadium exhibited similar wear loss results.
A Vision-Based Collision Warning System by Surrounding Vehicles Detection
( Bing-fei Wu ),( Ying-han Chen ),( Chih-chun Kao ),( Yen-feng Li ),( Chao-jung Chen ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.4
To provide active notification and enhance drivers` awareness of their surroundings, a vision-based collision warning system that detects and monitors surrounding vehicles is proposed in this paper. The main objective is to prevent possible vehicle collisions by monitoring the status of surrounding vehicles, including the distance to the other vehicles in front, behind, to the left and to the right sides. In addition, the proposed system collects and integrates this information to provide advisory warnings to drivers. To offer the correct notification, an algorithm based on features of edge and morphology to detect vehicles is also presented. The proposed system has been implemented in embedded systems and evaluated on real roads in various lighting and weather conditions. The experimental results indicate that the vehicle detection ratios were higher than 97% in the daytime, and appropriate for real road applications.
Li-Chin Chen,Chun-Chih Lin,Chin-Yen Han,Chun-Lan Hsieh,Chiung-Jung (Jo) Wu,Hwey-Fang Liang 한국간호과학회 2018 Asian Nursing Research Vol.12 No.1
Purpose: This study aims to gain in-depth understanding of nurses' perspectives of working in an overcrowded emergency. Methods: Symbolic interactionism and Charmaz’s construction of grounded theory were used. Purposive sampling at the start of the study and a further theoretical sampling by snowball technique were used to recruit 40 registered nurses (RN) to participate in in-depth, semi-structured interviews betweenMay and November, 2014. Data analysis included analytic techniques of initial, focused and theoretical coding. Results: Study findings showed searching for work role is derived by the themes of Finding the role of positioning in Emergency Department (ED), Recognizing causes of ED overcrowding, and Confined working environment. Nurses' work experience which represents the RNs not gained control over their work, as care actions influenced by the problematic overcrowded circumstance of the ED environment. Conclusion: The findings fill a gap in knowledge about how RNs experience their work role in the context of an overcrowded Emergency Department in Taiwan. Arising from the study result include taking account of nurses' perspectives when planning staff/patient ratios, strategies to reduce waiting time and ensure that clients receive appropriate care.
A New Reference Pixel Prediction for Reversible Data Hiding with Reduced Location Map
( Jeanne Chen ),( Tung-shou Chen ),( Wien Hong ),( Gwoboa Horng ),( Han-yan Wu ),( Chih-wei Shiu ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.3
In this paper, a new reversible data hiding method based on a dual binary tree of embedding levels is proposed. Four neighborhood pixels in the upper, below, left and right of each pixel are used as reference pixels to estimate local complexity for deciding embeddable and non-embeddable pixels. The proposed method does not need to record pixels that might cause underflow, overflow or unsuitable for embedment. This can reduce the size of location map and release more space for payload. Experimental results show that the proposed method is more effective in increasing payload and improving image quality than some recently proposed methods.