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        Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

        Yi Yang,Hong Wang,Ming Zhang,Mengxue Shi,Cailing Yang,Qiang Ni,Qi Wang,Jing Li,Xuemei Wang,Chen Zhang,Zhi Li 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4

        Background: In physical activity or labor, the human body is in a state of high intensity stress, and allparts or physiological functions of the body respond positively to maintain or balance the need formovement. The human body has many physiological changes in the process of movement, and fatigue isthe external manifestation of various complex changes inside the human body. Fatigue is also a physiologicalmechanism of self-protection after the body reaches a certain level of activity, which can preventthe occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complexprocess, and its mechanism has not been concluded yet. Therefore, it is an important work to search andscreen the effective components of natural plants that have anti-fatigue effect and to explore theirmechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110subjects who passed physical examination were included according to the scheme design, and randomlydivided into a test group which was given KRG and a placebo control group. The calculation is carried outaccording to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. AfterKRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acidcontent is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significantlower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful onrelieving physical fatigue.

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        Decomposition of Interference Hyperspectral Images Based on Split Bregman Iteration

        ( Jia Wen ),( Lei Geng ),( Cailing Wang ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.7

        Images acquired by Large Aperture Static Imaging Spectrometer (LASIS) exhibit obvious interference stripes, which are vertical and stationary due to the special imaging principle of interference hyperspectral image (IHI) data. As the special characteristics above will seriously affect the intrinsic structure and sparsity of IHI, decomposition of IHI has drawn considerable attentions of many scientists and lots of efforts have been made. Although some decomposition methods for interference hyperspectral data have been proposed to solve the above problem of interference stripes, too many times of iteration are necessary to get an optimal solution, which will severely affect the efficiency of application. A novel algorithm for decomposition of interference hyperspectral images based on split Bregman iteration is proposed in this paper, compared with other decomposition methods, numerical experiments have proved that the proposed method will be much more efficient and can reduce the times of iteration significantly.

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        Antimicrobial property of recombinant Lactolisterin BU in vitro and its initial application in pork refrigerated storage

        Dong Bin,Zhou Guowen,Lin Yanjun,Yu Cailing,Wang Jun,Sun Chunlong,Wu Tao 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.5

        Lactolisterin BU is a novel bacteriocin identified from Lactococcus lactis in 2017. It exhibits antimicrobial activity against food spoilage and foodborne pathogens. In this study, Lactolisterin BU was expressed in Pichia pastoris (P. pastoris) and isolated from the supernatant of yeast culture for the first time. It was found to exhibit a broad antimicrobial spectrum and rapid bactericidal activity against foodborne bacterial pathogens, both gram-positive and gramnegative ones, with minimum inhibition concentrations ranging within 10–60 μg/mL. The recombinant Lactolisterin BU (rLactolisterin BU) also had an antioxidant effect and was resistant to heating, acid–base, and high-dose-saline treatments and barely had any hemolytic activity or cytotoxicity. Moreover, rLactolisterin BU effectively suppressed the growth of bacterial pathogens; suppressed the increases in pH, total volatile basic nitrogen (TVB-N), and thiobarbituric acid reactive substances (TBARS) of pork samples; and maintained a high quality of fresh pork during storage at 4 ℃. Furthermore, rLactolisterin BU effectively inhibited the growth of three kinds of bacteria in a pork-spoilage model. Taken together, rLactolisterin BU could be a promising preservative for food storage.

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