The association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression in patients with rheumatoid arthritis

Cheon, Yun-Hong,Lee, Seung-Geun,Kim, Mingyo,Kim, Hyun-Ok,Sun Suh, Young,Park, Ki-Soo,Kim, Rock Bum,Yang, Hyun-Su,Kim, Ji-Min,Son, Chang-Nam,Kyoung Park, Eun,Kim, Sang-Hyon,Lee, Sang-Il Elsevier 2018 Brain, behavior, and immunity Vol.73 No.-

<P><B>Abstract</B></P> <P>Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], vascular endothelial growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor-1) are associated with depression in the general population. Rheumatoid arthritis (RA) is a chronic representative inflammatory autoimmune disease; however, the association of disease activity, pro-inflammatory cytokines, and neurotrophic factors with depression has not been sufficiently investigated. Therefore, we determined the prevalence of depression and risk factors for depression and deterioration of depressive symptoms in RA patients. In addition, we analyzed the association between disease activity, pro-inflammatory cytokines, trophic factors, and depression in RA (N = 474). Demographic and laboratory data were examined, and routine assessment of patient index data 3 (RAPID 3) and disease activity score 28-joint count C-reactive protein (DAS 28-CRP) was performed to assess disease activity of RA. Depression was measured using the Korean version of the Beck Depression Inventory-second edition (K-BDI II). A K-BDI score ≥18 was considered the cut-off for depression in accordance with a previous validation study. The serum level of pro-inflammatory cytokines and neurotrophic factors was assessed by enzyme-linked immune sorbent assay. The prevalence of depression was 32.4% in patients with RA. The severity of disease activity of RA (RAPID 3 score [OR 2.34; 95% confidence interval, CI 1.22–4.51], DAS 28-CRP [≥3.2] [OR 1.60, 95% CI 1.01–2.53]) and severity of fatigue (OR 1.26 95% CI 1.15–1.38) were associated with depression and deterioration of depressive symptoms in the multivariate analysis. Among the components of RAPID 3 and DAS 28-CRP, patient assessment for global health and abilities for daily performance were more related to depression. The level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) was not related to depression. The level of BDNF was significantly lower in RA patients with depression and was negatively correlated with K-BDI II score. Depression was related with the level of fatigue, low expression of BDNF, and high RA disease activity, which was associated with impaired ability to perform activities of daily life. Strict control of fatigue and disease activity to improve one’s capacity to perform daily life activities would be important to regulate depression. The level of BDNF might be one of the possible biomarkers to predict or monitor depression in patients with RA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Prevalence of depression in patients with rheumatoid arthritis (RA) was analyzed. </LI> <LI> Risk factors for depression and deterioration of depressive symptoms and were analyzed. </LI> <LI> Depression was related with disease activity in RA. </LI> <LI> Depression in RA was associated with impaired ability to perform activities of daily life. </LI> <LI> Among neurotrophic factors, the level of BDNF was related with depression in RA patients. </LI> <LI> The level of pro-inflammatory cytokines were not related with depression in RA patients. </LI> </UL> </P>

黃化水素化合物이 紫外線B를 照射한 黑色마우스의 表皮멜라닌細胞의 形態에 미치는 影響

明基範,鞠泓一 梨花女子大學校 韓國生活科學硏究院 1989 韓國生活科學硏究院 論叢 Vol.44 No.-

C57BL 흑색마우스에 UVB를 매일 100mJ/cm^2씩 10일간 조사하여 표피멜라닌세포를 활성화시킨 후 5% cysteine과 5% glutathione이 표피멜라닌세포의 수적 변화와 멜라닌소체 형태변화에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. Cysteine 투여군에서는 멜라닌세포의 수적변화가 없었으며 glutathione투여 5주 후에서만 멜라닌세포의 수가 감소하였다. 2. Cysteine 투여군과 glutathione 투여군은 대조군에 비해 표피멜라닌세포내 멜라닌소체의 단축 길이와 stage Ⅳ 멜라닌소체 비율에 유의한 감소를 보여 멜라닌형성 억제제로서 의의있는 효과를 나타내었다. 3. 두 실험군간의 비교에서 멜라닌소체 단축길이는 glutathione 투여군에서 투여 3주 후에 cysteine 투여군보다 의의있게 감소되었으며, stage Ⅳ 멜라닌소체의 비율은 glutathione 투여군에서는 투여 3주 후에 cysteine 투여군에서는 투여 5주 후에 각각 유의한 감소소견을 보였다. 4. Glutathione 투여군에서는 멜라닌소체 단축길이와 stage Ⅳ 멜라닌소체의 비율이 모두 투여기간에 비례하여 감소되었다. 이상과 같은 결과로 황화수소화합물인 cysteine과 glutathione은 자외선 B조사로 활성화된 표피멜라닌세포내 멜라닌소체의 단축길이와 stage Ⅳ 멜라닌소체의 비율을 감소시킴으로써 멜라닌형성을 억제하고, glutathione이 cysteine보다 멜라닌형성억제에 우수한 효과를 나타냄을 알수 있었다. The effects of sulfhydryl compounds, cysteine and glutathione, on populations of melanocytes, the sizes of melanosomes and the ratios of melanosomal stages of epidermal melanocytes in UVB-irradiated C57BL black mice were evaluated. The results were as follow: 1. Both of cysteine and glutathione showed no significant diminution in the numbers of dopa-positive melanocytes except at the end of 5 weeks' treatment with glutathione. 2. Both of cysteine and glutathione showed significant diminution in short axis of melanosomes and the percentage of stage Ⅳ melanosomes of epidermal melanocytes. 3. The lengthes of short axes of melanosomes in glutathione-treated group were smaller than those in cysteine-treated group at the end of 3rd week of intraperitoneal injection. 4. In the glutathione-treated group, the short axes of melanosomes and the percentages of stage Ⅳ melanosomes decreased in proportion to the period of intraperitoneal injection.

불완전휴식이 에너지대사와 혈중지질에 미치는 영향

민범일,허건홍 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

This study was designed to inverstigate the effects of resting methods - active rest and inactive rest-after exercise of maximum of gradual load, on energy metabolism and Blood Lipids. I surveyed 6 male basketball players in a high school in order to investigate the effects on exercise spot and analysed the relations of blood variations before and after exercise of maximum of gradual load with a treadmill and 3, 6, l0minutes after recovery step. the results was as follows; In the difference between active and inactive resting method, to make a comparatived of Albumin, Glucose and Total-Protein appeared respectively 6minutes after the recovery step. Albumin and Total-Protein were significant differences (P<.05) in group and time, glucose was significant differences(P<.05) in time and method x time. In the difference between active and inactive resting method, to make a comparatived of Total-Cholesterol and Triglyceride appeared respectively each group. Total-Cholesterol was significant differences(P<.05) in group and time, Triglyceride was significant differences(P<.05) in method.

장기간 요가운동이 알코올의존자의 면역글로블린에 미치는 영향

민범일,김홍식,김성곤 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

The purpose of this study was to investigate the effect of Yoga exercise on Immunoglobulin(IgE, IgM, IgD, IgG, IgA) in the alcoholism. The subjects involved in this study consists of 14 people who were confirmed to have alcohol-related problems by DSM-Ⅳ(1994) of American Psychiatric Association and were diagnosed as alcoholism in hospital. The subjects were classified into yoga exercise group(7 people) and control group(7 people). The yoga exercise group participated in the exercise programs named Hatayoga and Asana. This treatment was performed an hour per day, three days a week for 16 weeks while the control group watched TV for the same time. A paired t-test was used to examine differences between pre, post 8weeks and post 16weeks test scores. The results are as follows. After 16 week yoga exercise, there was a significant increase(p<.01) of Immunoglobulin (IgM, IgA(p<.05) & IgG) in the experiment group, compared with the control group. In terms of periodic change, the experiment group showed a significant higher result(p<.01) than the control group after 16 weeks, rather than after the 8 weeks. The result of this study above indicates that the long-term low intensity exercise can activate Immunoglobulint in alcoholism.

혈관내초음파로 평가한 스텐트를 삽입한관동맥의 형태학적 특징

정남식,홍범기,임세중,백성일,이문형,장양수,심원흠,조승연,김성순 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

AN ERROR OF THE METHOD OF VANISHING VISCOSITY OF THE FIRST-ORDER HAMILTON-JACOBI EQUATIONS

Hong, Bum Il,Ha, Sung Nam,Choi, Jeongwhan 대한수학회 1997 대한수학회보 Vol.34 No.1

ON REGULARITY AND APPROXIMATION FOR HAMILTON-JACOBI EQUATIONS

Hong, Bum Il 대한수학회 1993 대한수학회지 Vol.30 No.1

ON A MOVING GRID NUMERICAL SCHEME FOR HAMILTON-JACOBI EQUATIONS

Hong, Bum Il 대한수학회 1996 대한수학회지 Vol.33 No.2

A Bound of the Correlation Function of Simpson's Quadrature

Hong, Bum Il 경희대학교 자연과학종합연구원 1998 자연과학논문집 Vol.4 No.-

When we study the problem of computing a posteriori bounds on the error of Simpson's quadrature the error bounds as well as the approximation to the integral ∫_(0)^(1)f(x)dx are computed based on a (fixed) finite number of function values. In this paper, we compute the bound of the correlation function with the probability measure w_(r) which is Gaussian measure with zero measure in order to calculate a posteriori bounds possible.

An Error Bound for Simpson's Quadrature

Hong, Bum Il,Park, Seongil 경희대학교 자연과학종합연구원 1999 자연과학논문집 Vol.5 No.-

일반적으로 수치적분에서 Worst case setting을 이용하여 오차 계산을 하지만 본 연구는 probabilistic case setting을 이용하여 심슨 공식의 오차를 γ≤5 경우 conditional variance를 이용하여 det(C)/σ_(Y)=Θ(h^(2γ+2))임을 보인다. In general, the worst case setting is mainly used for the error estimate in the numerical integration. In this study, we use the probabilistic setting for an error estimate for Simpson's quadrature and show that for r≤5 and subintervals of equal length, the conditional variance of X, given Y=y, is det(C)/σ_(Y) = θ(h^(2r+2)).