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1
Effect of LED Wavelength on Growth and Production of Astaxanthinin Haematococcus Pluvialis

( Boyd Warren ),( Ki An Kim ),( Sang Ho Chun ),( Tae-hawn Oh ),( Woo-hyuk Jung ),( Kyoo Jin Jung ),( Sung-kun Yim ) 한국키틴키토산학회 2020 한국키틴키토산학회지 Vol.25 No.3
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Biomass production and astaxanthin accumulation in Haematococcus pluvialis were investigated under different light-emitting diode (LED) wavelengths. The maximum biomass (5.41 and 6.25 g dry weight/L) was obtained under the red LEDs (630 nm and 660 nm) with light intensity of 200 μmol m-2s-1 at day 7 after cultivation in mixotrophic media with modified Bold’s Basal Medium including sodium acetate. The highest astaxanthin content (31.4 mg/g dry weight biomass) was accumulated when incubated under red LEDs (630 nm) for 4 days by increasing the light intensity to 1,000 μmol m-2s-1. In these results, we propose an efficient way of cultivating H. pluvialis in mixotrophic media under red (630 nm) LEDs for maximum biomass production and then increasing the light intensity over 1,000 μmol m-2s-1 to induce a high level of astaxanthin content.
2
CADASIL as a Useful Medical Model and Genetic Form of Vascular Depression

Park, Joon Hyuk,Jeon, Bong-Hee,Lee, Jung Seok,Newhouse, Paul A.,Taylor, Warren D.,Boyd, Brian D.,Kim, Ki Woong,Kim, Moon-Doo Lippincott Williams & Wilkins 2017 American Journal of Geriatric Psychiatry Vol. No.
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Objective: The main magnetic resonance imaging (MRI) findings of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are white matter hyperintensities (WMHs), lacunar infarctions, and cerebral microbleeds (CMBs). The purpose of this study was to investigate the effects of these three neuroimaging markers of CADASIL on depression to determine whether CADASIL is a useful medical model supporting the vascular depression hypothesis. Methods: Eighty-four subjects with CADASIL, aged 34-86 years, participated in this study. They underwent comprehensive clinical evaluation, including 3T MRI and genotyping of NOTCH3. The effects of WMH, lacunar infarctions, and CMBs were analyzed by path analyses and multivariate logistic regression analyses. Results: Patients with CADASIL exhibited frequencies of 17.9% for major depressive disorder (MDD) and 10.7% for minor depressive disorder. The frequency of MDD increased from 5.0% to 46.2% asWMH volume increased from first quartile to fourth quartile. WMH volume (OR: 1.03, 95% CI: 1.003-1.06) in patients with CADASIL was associated with the current depressive disorder. Path analyses demonstrated that only WMH volume was associated with the Korean version of the short form Geriatric Depression Scale score, Center for Epidemiologic Studies Depression Scale score, and 17-item Hamilton depression scale score. The effects of lacunar infarctions and CMBs on depression were not significant in path analyses and multivariate logistic regression analyses. Conclusions: This study demonstrates that WMHs are closely associated with depression in patients with CADASIL. This supports that CADASIL might be a useful medical model and genetic form of vascular depression.