SVM을 기반으로 한 심음 기반의 심장 질환 판별에 관한 연구

金寶利,白承和,金東完 明知大學校 産業技術硏究所 2007 産業技術硏究所論文集 Vol.26 No.-

In this paper, Support Vector Machine Algorithms were used with promising results in various critical problems, concerning heart sound classification. In general this classification problem can be divided in many sub problems, each one dealing either with one morphological characteristic of the heart sound or with difficult to distinguish heart diseases. We proposed a ventricular fibrillation detection algorithm based on support vector machine classifier and Short Time Vector Machine, which could offer benefits to reduce the learning costs as well as good classification performance. It showed similar or higher values. Consequently, we could find that the proposed input features and SVM classifier would one of the most useful algorithm for cardiac disorder detection.

고등학교 보건교육 교육과정 선정을 위한 조사 연구

이보은,김명,김애리 이화여자대학교 교과교육연구소 1998 교과교육학연구 Vol.2 No.1

The purpose of this study was to identify the health status, perception and experience for health education, needs for health education contents in high school students and to select areas and contents of health education curriculum. This study was surveyed 728 adolescents in high school from Sep. 11 1997 till Sep. 26 1997. The results were as follows. 1. For the perceived health status, 65.5% of the boys and 59.8% of the girls answered they were healthy. 18.8% of the boys and 59.8% of the girls experienced disease during the last year. 2. 67.3% of the boys and 71.6% of the girls acknowledge the necessity of health education. 3. For the experience of healty education, girls(82.7%) were reported high experience rates than the boys(51.3%). To the question of the instruction period, boys answered as middle school(84.0%) and girls as high school(77.2%). To the instruction teacher, many of respondents answered the school nurse(boys 80.0%, girls 73.3%). The satisfaction for contents they were taught were low(boys 21.4%, girls 31.7%). 4. The most desired areas of health education were Sex Education and Mental Health. The following were Health-Habit and Prevention of Disease in a sequent order. 5. The boys showed a high acknowledgement on Sex education, nutrition and Mental Health. 6. The girls showed a high acknowledgement on Sex education, nutrition and Mental Health. 7. The areas of health education curriculum were selected as follws: Nutrition, Growth and Development, Health-Habits, Prevention of Disease, Mental Health, Tabacco, Alcohol and other Drugs, Safety Education, Sex Education, Family Life and Health, Enviromental Health, Consumer Health.

Predictive Model for Differential Diagnosis of Inflammatory Papular Dermatoses of the Face

( Bo Ri Kim ),( Minsu Kim ),( Chong Won Choi ),( Soyun Cho ),( Sang Woong Youn ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.4

Background: The clinical features of inflammatory papular dermatoses of the face are very similar. Their clinical manifestations have been described on the basis of a small number of case reports and are not specific. Objective: This study aimed to use computer-aided image analysis (CAIA) to compare the clinical features and parameters of inflammatory papular dermatoses of the face and to develop a formalized diagnostic algorithm based on the significant findings. Methods: The study included clinicopathologically confirmed inflammatory papular dermatoses of the face: 8 cases of eosinophilic pustular folliculitis (EPF), 13 of granulomatous periorificial dermatitis-lupus miliaris disseminatus faciei (GPD-LMDF) complex, 41 of granulomatous rosacea- papulopustular rosacea complex (GR-PPR) complex, and 4 of folliculitis. Clinical features were evaluated, and area density of papular lesions was quantitatively measured with CAIA. Based on these variables, we developed a predictive model for differential diagnosis using classification and regression tree analysis. Results: The EPF group showed lesion asymmetry and annular clusters of papules in all cases. The GPD-LMDF complex group had significantly higher periocular density. The GR-PPR complex group showed a higher area density of unilateral cheek papules and the highest total area density. According to the predictive model, 3 variables were used for differential diagnosis of the 4 disease groups, and each group was diagnosed with a predicted probability of 67%∼100%. Conclusion: We statistically confirmed the distinct clinical features of inflammatory papular dermatoses of the face and proposed a diagnostic algorithm for clinical diagnosis. (Ann Dermatol 32(4) 298∼305, 2020)

Molecular Cloning and Oxidative Stress Response of a Sigma-Class Glutathione S-Transferase of the Bumblebee Bombus ignitus

Bo Yeon Kim,Kwang Sik Lee,Hu Wan,Mi Ri Sohn,Yuling Qiu,Hyung Joo Yoon,Byung Rae Jin 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10

Glutathione S-transferases (GSTs) are multifunctional enzymes that are mainlyinvolved in the xenobiotic metabolism and protection against oxidative damage. Most studies of GSTs in insects have been focused on their role in detoxifying exogenous compounds in particular insecticides. Here, we show the expression profiles of GSTs of the bumblebee Bombus ignitus in response to oxidative stress. We identified a sigma-class GST from B. ignitus (BiGSTS). The BiGSTSgene consists of 4 exons that encode 201 amino acids. Comparative analysis indicates that the predicted amino acid sequence of BiGSTS shares a high identity with the sigma-class GSTs of hymenopteran insects such as Apis mellifera (70% protein sequence identity) and Solenopsis invicta (59% protein sequence identity). Tissue distribution analyses showed the presence of BiGSTS in all tissues examined, including the fat body, midgut, muscle and epidermis. The oxidative stress responses analyzed by quantitative real-time PCR showed that under H2O2 overload, BiGSTS and BiGSTD (identified in our previous study) were upregulated in all tissues examined, including the fat body and midgut of B. ignitus worker bees. Under uniform conditions of H2O2 overload, the expression profile of GSTs and other antioxidant enzyme genes, such as phospholipid-hydroperoxide glutathione peroxidase (Bi-PHGPx) and peroxiredoxins (BiPrx1 and BiTPx1), showed that other antioxidant enzyme genes are acutely induced at 3 h after H2O2 exposure, whereas BiGSTS and BiGSTD are highly induced at 9 h after H2O2 exposure in the fat body of B. ignitus worker bees. These findings indicate that GSTs and other antioxidant enzyme genes in B. ignitusare differentially expressed in response to oxidative stress. Taken together, our findings indicate that BiGSTS and BiGSTD are oxidative stress-inducible antioxidant enzymes that may play a role in oxidative stress response.

Differentiation of Jessner’s lymphocytic infiltration of the skin from various chronic cutaneous lupus erythematosus subtypes by quantitative computer- aided image analysis

( Bo Ri Kim ),( In Su Kim ),( Sang Woong Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: The distinction between chronic cutaneous lupus erythematosus and Jessner’s lymphocytic infiltration of the skin using conventional clinico-pathological diagnostic methods remains a challenge. Objectives: The aim of this study was to investigate the difference between chronic cutaneous lupus erythematosus and Jessner’s lymphocytic infiltration of the skin in an objective and quantitative manner. Methods: Clinical photographs were examined for erythema quantification using two erythema parameters (a* and erythema dose), and histologic images were assessed for computer-aided image analysis of inflammatory dermal cell infiltration and epidermalthickness. A total of 9 patients diagnosed with Jessner’s lymphocytic infiltration of the skin, 13 with lupus erythematosus tumidus, and 5 with discoid lupus erythematosus were included. Results: The difference between normal and erythematous skin was more prominent using erythema dose than a*, but no significant differences among the three diseases were observed. The correlation between inflammatory dermal cell infiltration and epidermal thickness was not significant. Conclusion: This is the first attempt to use computer-aided image analysis for the differentiation of similar skin diseases. However, the differentiation between Jessner’s lymphocytic infiltration of the skin and chronic cutaneous lupus erythematosus using quantitative computer-aided image analysis was still not possible.

Subclinical systemic and vascular inflammation detected by 18F-fluorodeoxyglucose positron emission tomography/ computed tomography in patients with mild psoriasis

( Bo Ri Kim ),( Gyeong Yul Park ),( Seo Young Kang ),( Sung Ae Kim ),( Won Woo Lee ),( Sang Woong Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Severe psoriasis is a systemic inflammatory disease involving major arteries and internal organs. However, it is not clear whether mild psoriasis increases the arterial inflammation and cardiovascular disease. Objectives: We aimed to investigate systemic inflammation using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in patients with mild psoriasis. Methods: In a nested case-control study, FDG-PET/CT findings of 10 patients with mild chronic plaque psoriasis involving a body surface area of less than 5% were compared with those of 10 age- and sex-matched healthy controls. The degree of FDG uptake in the large arteries (ascending aorta, aortic arch, descending aorta, suprarenal abdominal aorta and infrarenal abdominal aorta,) and liver were analyzed using the maximum target-to-background ratios (TBR). Results: There were no significant demographic differences between the psoriasis patients and the control subjects. Patients with psoriasis showed higher maximum TBR than healthy controls in all examined arterial segments, with statistical significance reached in the suprarenal abdominal aorta, ascending thoracic aorta and infrarenal abdominal aorta, and in the liver. The “candy cane sign”, which represents arterial inflammation of the thoracic aorta, was noted upon PET in the majority of psoriasis cases. Conclusion: Mild psoriasis is associated with arterial and hepatic inflammation, which can be readily demonstrated by using FDG-PET/CT.

P122 Identification of nail features associated with psoriasis severity

( Bo Ri Kim ),( Jee Woong Choi ),( Eunmi Seo ),( Sang Woong Youn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: There are no detailed studies of the prevalence of nail psoriasis and clinical characteristics of psoriatic nail involvement. Objectives: To investigate the prevalence and characteristics of psoriatic nail involvement in patients with psoriasis and determine the relationship between psoriatic nail features and severity of nail and cutaneous psoriasis Methods: A single-center, noninterventional, cross-sectional observational cohort study was conducted. Results: The prevalence of nail psoriasis was 85.5%. Pitting was the most common clinical feature in psoriatic nails (55.6%). When comparing the mean NAPSI and the mean PASI according to nail lesions, we found that subungual hyperkeratosis (SH) and nail fold psoriasis (NFP) were significantly associated with the severity of both nail psoriasis and cutaneous psoriasis. Psoriatic nail changes were most common in the first digit. Conclusion: The majority of patients with psoriasis had psoriatic nail involvement, and Kobner’s isomorphic response seems to be closely related to the induction of nail psoriasis. To limit progression of the disease, psoriatic patients with SH and NFP should be examined thoroughly because those clinical features reflect the levels of severity of both nail and cutaneous psoriasis.

P331 : Beau`s Line and onychomadesis after hand-footmouth disease

( Bo Ri Kim ),( Eun Jee Kim ),( Sang Young Byun ),( Hyeong Ho Ryu ),( Hyun Sun Yoon ),( Hyun Sun Park ),( So Yun Cho ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

Reduction of Inter-rater and Intra-rater variability in psoriasis area and severity index assessment by photographic training

( Bo Ri Kim ),( Je Byeong Chae ),( Chong Won Choi ),( Sang Woong Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Severity grading is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PASI assessment. Objectives: We aimed to investigate whether photographic training improves inter-rater and intra-rater variabilities. We also determined which PASI component has the greatest impact on variability. Methods: Twenty-one dermatologists received 1 hour of PASI training. They were tested before and after the training to evaluate intra-rater variability. The physicians were further tested after training by using a reference photograph. Results: The mean of each PASI component was underevaluated compared with scoring by a PASI expert. The concordance rate with the expert’s grading was highest for thickness followed by erythema, scaling, and area. The scaling score showed the greatest improvement after training. After training, the distribution of deviation from the expert’s grading, which signifies inter-rater variability, improved only for the PASI area component. The deviation of scaling grading improved upon retesting by using a reference photograph. Conclusion: PASI assessment training improved variabilities to some degree but not for every PASI component. The development of an objective psoriasis severity assessment tool will help overcome the subjective variabilities in PASI assessment, which can never be completely eliminated via training.

Urinary metabolomic profiling for noninvasive diagnosis of acute T cell-mediated rejection after kidney transplantation

Kim, Sun-Young,Kim, Bo Kyung,Gwon, Mi-Ri,Seong, Sook Jin,Ohk, Boram,Kang, Woo Youl,Lee, Hae Won,Jung, Hee-Yeon,Cho, Jang-Hee,Chung, Byung Ha,Lee, Sang-Ho,Kim, Yeong Hoon,Yoon, Young-Ran,Kim, Chan-Duck Elsevier 2019 Journal of chromatography. B, Analytical technolog Vol.1118 No.-

<P><B>Abstract</B></P> <P>To improve early renal allograft function, it is important to develop a noninvasive diagnostic method for acute T cell-mediated rejection (TCMR). This study aims to explore potential noninvasive urinary biomarkers to screen for acute TCMR in kidney transplant recipients (KTRs) using untargeted metabolomic profiling.</P> <P>Urinary metabolites, collected from KTRs with stable graft function (STA) or acute TCMR episodes, were analyzed using liquid chromatography-mass spectrometry (LC-MS). Multivariate statistical analyses were performed to discriminate differences in urinary metabolites between the two groups. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of potential urinary biomarkers.</P> <P>Statistical analysis revealed the differences in urinary metabolites between the two groups and indicated several statistically significant metabolic features suitable for potential biomarkers. By comparing the retention times and mass fragmentation patterns of the chemicals in metabolite databases, samples, and standards, six of these features were clearly identified. ROC curve analysis showed the best performance of the training set (area under the curve value, 0.926; sensitivity, 90.0%; specificity, 84.6%) using a panel of five potential biomarkers: guanidoacetic acid, methylimidazoleacetic acid, dopamine, 4-guanidinobutyric acid, and <I>L</I>-tryptophan. The diagnostic accuracy of this model was 62.5% for an independent test dataset.</P> <P>LC-MS-based untargeted metabolomic profiling is a promising method to discriminate between acute TCMR and STA groups. Our model, based on a panel of five potential biomarkers, needs to be further validated in larger scale studies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We explored urinary biomarkers for acute TCMR using LC-MS-based metabolomics. </LI> <LI> OPLS-DA well distinguished between acute TCMR and STA groups. </LI> <LI> Multivariate statistical analyses revealed differences in urinary metabolites. </LI> <LI> ROC curve analysis evaluated the performance of potential urinary biomarkers. </LI> </UL> </P>