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RISS 인기검색어
- 검색키워드
- 저자 : ( Bashu Dev Pardhe ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Assessment of Liver Parameters among Type 2 Diabetic Nepalese Patients
( Bashu Dev Pardhe ),( Goverdhan Joshi ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Diabetes Mellitus (DM) is one of the major lifestyle-related metabolic disorders with emerging high incidence around the globe. The prevalence rate of type-II Diabetes Mellitus is around 8.4% as per the data of 2014 in Nepal and is increasing yearly. It is associated with different patterns of liver diseases like fatty liver, cirrhosis, and acute liver failure. Early assessment of liver profile parameters helps to establish different patterns of liver diseases providing better information for the management and cure of possible liver damages in type-II diabetic populations. The present study was conducted with the aim to assess the liver profile markers in type-II Diabetic Nepalese population. Methods: A total number of 170 patients were included in descriptive cross-sectional study conducted at Manmohan Memorial Community Hospital. Among them, 85 were type 2 Diabetic and 85 were control population. Fasting blood glucose, postprandial blood glucose and HbA1C were estimated to diagnose Diabetes Mellitus and AST, ALT, ALP, total protein and albumin were estimated to assess liver function by using standard methods. The parameters were analyzed with SPSS version 20.0 and data with p value less than 0.05 was considered as statistically significant. Results: We observed the increased level of AST (15.4%) and ALT (25%) among patients with diabetes mellitus. Moreover, a significant level of elevation in AST and ALT was observed among the patients with diabetes mellitus compared to non-diabetic controls. Although not significant statistically, the level of ALP was also high among the diabetic group of patients. However, total protein, albumin and A/G ratio were significantly decreased in diabetic group of patients compared to non diabetic controls. Conclusions: Type-II DM is associated with mild chronic changes in transaminases and decrease hepatic functions (low plasma proteins). Routine assessment of liver parameters in those populations may prevent further complications associated with liver due to insulin resistance.
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Hidden Risk of Liver Disease in Type 2 Diabetes Population
( Sushant Pokhrel ),( Naresh Pokhrel ),( Bashu Dev Pardhe ),( Anit Lamichhane ),( Rakesh Pokhrel ),( Mahendra Prasad Bhatt ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: This study aimed to find the association of liver biomarker with diabetes population. Also, this study focused to find out the risk factors associated with liver disease in Nepalese diabetes patient. Methods: This study was carried out among 238 diabetes and 238 apparently healthy population who attended Modern diagnostic laboratory and Research center, Kathmandu, Nepal. HbA1c and fasting plasma glucose was measure to assess the diabetes population and glycemic control. Aspartate to platelet ratio index (APRI), gamma-glutamyl transpeptidase to platelet ratio (GPR), fibrosis-4 index (FIB-4), and triglyceride and glucose index (TyG) were assess for prediction of hidden risk liver disease. Diabetic patient with higher than the cut-off value obtained from ROC curve analysis of different liver marker index were subjected to multivariate regression analysis to measure the independent risk factor for progression liver disease in different model. Results: Patient with poor glycemic control had a significantly higher level of APRI (P=0.05), GPR (P=0.039), and TyG (P<0.001). Higher HbA1c showed significantly positive correlation with APRI (r=0.154, P=0.017), GPR (r=0.203, P=0.002), FIB4 (r=0.132, P=0.042), and TyG (r=0.510, P<0.001) in diabetic population. The Area under ROC curve of GPR was 0.700 (0.654-0.747), APRI 0.839 (0.803-0.874), FIB-4 0.820 (0.783-0.857), and TyG 0.909 (0.882-0.874) with p-value <0.05. The cut-off value (sensitivity, specificity) of GPR was 0.227 (63.4%, 63%), APRI 0.241 (71.0%, 80.3%), FIB-4 1.65 (71.8%, 77.3%), and TyG 8.85 (79%, 93.3%) respectively. Triglyceride, AST, and GGT was independent risk factor followed same trend in different 4 model while HbA1c and ALT showed independent risk factor in 3 models. Conclusions: APRI, GPR, FIB4 and TyG can define the hidden risk liver disease in T2DM. The independent risk factors for progression of liver disease in those population are hypertriglyceridemia, higher AST, and higher GGT. Routinely screening for markers may prevent progression of liver disease in T2DM patients.
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