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Magnetic Resonance Imaging-Based Volumetric Analysis and Its Relationship to Actual Breast Weight
Yoo, Anna,Minn, Kyung Won,Jin, Ung Sik Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.3
Background Preoperative volume assessment is useful in breast reconstruction. Magnetic resonance imaging (MRI) and mammography are commonly available to reconstructive surgeons in the care of a patient with breast cancer. This study aimed to verify the accuracy of breast volume measured by MRI, and to identify any factor affecting the relationship between measured breast volume and actual breast weight to derive a new model for accurate breast volume estimation. Methods From January 2012 to January 2013, a retrospective review was performed on a total of 101 breasts from 99 patients who had undergone total mastectomy. The mastectomy specimen weight was obtained for each breast. Mammographic and MRI data were used to estimate the volume and density. A standard statistical analysis was performed. Results The mean mastectomy specimen weight was 340.8 g (range, 95 to 795 g). The mean MRI-estimated volume was $322.2mL^3$. When divided into three groups by the "difference percentage value", the underestimated group showed a significantly higher fibroglandular volume, higher percent density, and included significantly more Breast Imaging, Reporting and Data System mammographic density grade 4 breasts than the other groups. We derived a new model considering both fibroglandular tissue volume and fat tissue volume for accurate breast volume estimation. Conclusions MRI-based breast volume assessment showed a significant correlation with actual breast weight; however, in the case of dense breasts, the reconstructive surgeon should note that the mastectomy specimen weight tends to overestimate the volume. We suggested a new model for accurate breast volume assessment considering fibroglandular and fat tissue volume.
Anna Yoo,아타나스데미레프,Ji Seon Lee,Sang Dal Kim,남두현 한국미생물학회 2006 The journal of microbiology Vol.44 No.6
A standard type II polyketide synthase (PKS) gene cluster was isolated while attempting to clone the biosynthetic gene for lipstatin from Streptomyces toxytricini NRRL 15,443. This result was observed using a Southern blot of a PstI-digested S. toxytricini chromosomal DNA library with a 444 bp amplified probe of a ketosynthase (KS) gene fragment. Four open reading frames [thioesterase (TE), β-ketoacyl systhase (KAS), chain length factor (CLF), and acyl carrier protein (ACP)], were identified through the nucleotide sequence determination and analysis of a 4.5 kb cloned DNA fragment. In order to confirm the involvement of a cloned gene in lipstatin biosynthesis, a gene disruption experiment for the KS gene was performed. However, the resulting gene disruptant did not show any significant difference in lipstatin production when compared to wild-type S. toxytricini. This result suggests that lipstatin may not be synthesized by a type II PKS.
Anna Cho,Danbi Yoon,Jiyoung Park,Jeong Seok Cha,Jiho Yoo 한국구조생물학회 2023 Biodesign Vol.11 No.4
Over 300 polypeptide substrates can undergo catalysis by the constitutively active Ser/Thr kinase, human casein kinase 2 alpha (hCK2α). Quercetin, a naturally occurring polyphenolic compound, is well-known for inhibiting hCK2α, thereby regulating cellular signaling pathways. In this study, we crystallized the hCK2α-quercetin complex to elucidate the inhibitory mechanism of quercetin on hCK2α through the complex structure. The hanging drop vapor diffusion method was employed for crystallizing the hCK2α-quercetin complex, and the resulting crystal diffracted to a resolution of 2.11 Å. X-ray diffraction data analysis revealed that the crystal of the hCK2α-quercetin complex belonged to the P43212 space group, with unit cell dimensions of a = b = 127.604 Å, c = 124.314 Å, and α = β = γ = 90.00°. In an initial density map, quercetin was bound well into hCK2α.
Eccrine porocarcinoma: retrospective study and review of cases reported in Korea
( Anna Kim ),( Jiehyun Jeon ),( Aeree Kim ),( Soo Hong Seo ),( Il Hwan Kim ),( Hae Jun Song ),( Yoo Sang Baek ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Eccrine porocarcinoma (EPC) is rare malignant cutaneous adnexal tumor. Since 1998, many EPC cases has been reported in Korea. All previous studies were limited to case report and none has comprehensively reviewed multiple cases. Objectives: To clinicopathologically review all EPC cases from our institutions as well as case reports in Korea. Methods: The patients were retrospectively selected from skin biopsy registry from our institutions. Available histopathological slides were re-examined by an experienced dermatopathologist. EPC cases reported in Korea before June 2019 were retrieved by searching PubMed, Google scholar, KoreaMed, and KoMCI. Results: Nine EPC cases from our institutions were included in the study. In addition, we found 27 reports of 28 EPC cases from Korea. In total of 37 EPC cases, there were 19 males (M:F ratio 1.06:1), and the mean age at diagnosis was 65.6 years. The most common site of primary tumor was head and neck (29.7%). Wide excision was the most common (78.4%) treatment method. Metastasis was confirmed in 21.1%. Conclusion: EPC is rarely reported cutaneous carcinoma in Korea. EPC usually affects old age patients with no sexual predilection. Due to possible metastasis, careful diagnosis and appropriate metastasis work up is warranted in EPC.