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PTGC(Progressively Transforming Germinal Center)의 임상 치험례
남두현,최환준,이영만,김미선 대한두개안면성형외과학회 2006 Archives of Craniofacial Surgery Vol.7 No.1
First described in 1975 by Lennert and Muller-Hermelink, progressively transforming germinal centers(PTGC) are follicular structures that are at least two to three times the diameter of a reactive follicle and are composed of small B lymphocytes with scattered centroblasts and follicular dendritic cells. PTGC may resemble the nodules of lymphocyte predominance Hodgkin’s disease(NLPHD) and are often seen in lymph nodes involved by NLPHD. The distinction between NLPHD and PTGC are difficult because of their histologic similarities. Many authors performed an immunohistochemical study to determine whether there might be immunophenotypic differences between these two processes to aid in the differential diagnosis. We experienced PTGC in sibling and two cases is presented with the review of literatures.
산약(Dioscorea Rhizoma)으로부터 Dioscin의 분리 분석
남두현,손건호,김종연,김순동,임상규 한국생약학회 2006 생약학회지 Vol.37 No.1
quantitative analytical method for the content of dioscin in Dioscorea rhizoma using a high performance liquidchromatography (HPLC) system was established for its quality control. After extracting Dioscorea rhizoma flour with ethanol,dioscin was separated through an ODS column with a flow rate of 1.0 ml/min of acetonitril-methanol-0.01 M phosphate bufferwere about 7.45±0.34 min and calibration curve showed good linearity at concentrations from 0.1 to 2.0 mg/ml of dioscin.When 5 commercial Dioscorea rhizoma flours were analyzed by HPLC, the peak for dioscin was well separated from othersin ethanol extract of Dioscorea rhizoma, and the amount of dioscin was in the range from 0.076 to 0.142(w/w)%.Key wordsDioscorea rhizoma, dioscin, HPLC, quantitative determination. ..... Dioscorea . ... .... .. ..
남두현,Sung Chull Kim,So-Young Park,Jong Min PARK 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Peptic ulcer (PU) disease has a high rate of occurrence and recurrence in Korean and the selection of drug for treatment is diverse. In this study, the therapeutical effectiveness of regimens including proton pump inhibitors (PPI) was compared with the single PPI therapy. The clinical data were collected from 1,658 patients having idiopathic or drug-induced PU complication from a Medical Center in Daegu, Korea, and analyzed retrospectively based on the results of endoscopic examination, the drug history and the therapeutic cost depending on drugs used. The comparison of complete healing rate and recurrence rate showed no significant differences between the single PPI groups and the combination group with antacids, prokinetic agent or mucosa protectants. However, the combination therapy of PPI with mucosa protectants gave a slightly better therapeutic outcome than single PPI treatment in gastric ulcer patients. Comparatively, the combination of PPI with antacids significantly reduced the therapeutic effectiveness in duodenal ulcer patients. The analysis of cost-based therapeutic effectiveness reveals that any economic benefits in PU treatment were not gained by the combination of other class of ulcer drugs. Even though the rapidity of healing rate was not considered, it can be concluded that the PPI combination therapy might be not desirable in PU treatment. Particularly triplet or quartet combination therapy in PPI regimen was absolutely economically ineffective therapy in spite of the increase of medication costs.
남두현 한국미생물학회 1992 微生物과 産業 Vol.18 No.3
방선균에서 항생물질을 발효 생산하기 위해서는 이와 관련된 방선균의 생리학적 및 생화학적 특성을 고찰해 볼 필요가 있다. 우선, 항생물질은 방선균의 2차 대사산물로써 이의 생산은 미생물의 성장과는 거의 연계되어 있지 않다. 즉, 방선균의 발효 과정을 살펴보면, 일반적으로 균체가 성장하는 증식 단계(trophophase)와 항생물질이 생산되는 발효 단계(idiophase)로 구분할 수 있다(2). 다시 말해서, 항생물질과 같은 2차 대사산물은 균체의 성장이 어느 정도 완료되어진 이후에 생합성되어지기 시작하며, 이는 방선균의 생활 주기상의 분화과정과도 밀접한 관계를 갖고 있는 것으로 알려져 있다. 또 하나의 특징은 한 종류의 방선균으로부터 유사한 화학적 골격을 지닌 여러 종의 항생물질들이 동시에 생산되어지는 경우가 많으며, 외부 환경에 따라 그 생산량이 크게 영향을 받는다는 사실이다. 따라서 방선균에서 목적하는 항생물질만을 과량생산하기 위해서는 배지의 조성을 비롯하여 pH, 발효온도, 통기, 점도 등 여러가지 발효 조건들을 잘 조절해 주어야 한다. 이러한 관점에서 방선균을 이용한 항생물질 발효에 있어서 그 생산량을 증대시키기 위해 고려해 주어야 할 사항들을 고찰해 보기로 한다.