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      • Effect of location of load on shear lag behavior of bonded steel-concrete flexural members

        Ankit Bhardwaj,Ashok K. Nagpal,Sandeep Chaudhary,Vasant Matsagar 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.1

        Shear lag is one of the governing phenomena considered in the design of flanged flexural members. The effect of the location of load on shear lag is not well understood yet. This paper presents a study to understand the shear lag behavior in the concrete slab of bonded steel-concrete composite flexural members, conducted with the help of a developed three-dimensional finite element model. The effect of the location of load on shear lag behavior is studied with the help of twelve loading arrangements at the service and the ultimate loads. Three effective widths based on different design criteria are used to understand the effect of the location of load on effective width. These effective widths are effective width for deflection at the service load, effective width for maximum stress at the service load, and effective width for bending moment capacity at the ultimate load. The shear lag behavior is found to be significantly affected by the location of the load. Increase in scaled eccentricity causes shear lag to vary from positive to negative.

      • KCI등재

        Bond Behavior in Flexural Members: Numerical Studies

        Ankit Bhardwaj,Vasant Matsagar,A.K. Nagpal,Sandeep Chaudhary 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.1

        Adhesive bonding has recently emerged as an alternative to shear stud connection in steel–concrete composite fl exural members. Research on adhesive-bonded steel–concrete composite fl exural members is in a preliminary stage, and the behavior of the bond layer in these structures is not well understood yet. A three-dimensional fi nite element model is developed and used to conduct the parametric investigations. The developed model is validated with experimental results available in the literature. The behavior of the bond layer is defi ned in terms of normal stress, normal strain, shear stress, and shear strain. Seven diff erent parameters are studied regarding their eff ect on the behavior of the bond layer. The parameters include load proportion factor, longitudinal distribution of load, transverse distribution of load, width of concrete slab, depth of the concrete slab, Young’s modulus of the adhesive and transverse location of the adhesive fi ber. Parametric investigations are carried out to establish the relevance of parameters in terms of their eff ect on the behavior of the bond layer. The most signifi cant parameters are identifi ed as load proportion factor, longitudinal distribution of load, and Young’s modulus of adhesive.

      • Natural History of Patients with Compensated Cirrhosis and a Hepatic Venous Pressure Gradient >20 mm Hg: A Prospective Longitudinal Cohort Study

        ( Aditi Gupta ),( Ankit Bhardwaj ),( Ankur Jindal ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: HVPG >10 mm Hg predicts clinical decompensation (CD) in compensated cirrhotics. A few cirrhotics exhibit high HVPG (>20mm Hg) despite no CD. Their natural history, pattern of CD (ascites, hepatic encephalopathy, variceal bleed) and complications (HCC, mortality) is largely unknown. Methods: Consecutive compensated cirrhosis patients with HVPG >5 mm Hg (n=747) were followed up every 3-6 monthly for CD. They were sub-classified at baseline based on HVPG (< 12 mmHg (low HVPG group), 12-20 mmHg (Intermediate HVPG group) and >20 mmHg (High HVPG group). We analyzed only the low and high HVPG groups. Multivariate Logistic regression was used to identify predictors Results: 295(39.4%) patients developed clinical decompensation (CD) at mean follow up of 1.9 ± 0.3 years. In comparison to low HVPG group, first CD in high HVPG group developed early (1.4 ± 0.3 years vs 2 ± 0.3 years, P=0.02), more frequently (ascites- 27.1% vs 13.2%, variceal bleed- 31.9% vs 7.9%, AKI- 31% vs 12.8%, HCC- 12.4% vs. 3.9%; all P<0.05) with higher mortality (15.9% vs 1.9%; P<0.05). There was no significant correlation between baseline HVPG level and grade of esophageal varices (P=0.457). All patients in high HVPG group received carvedilol (maximum dose-25 mg/d, divided) and a repeat HVPG measured after a mean duration of 1.8 ± 0.4 years showed suboptimal HVPG response (≥20% reduction in HVPG or < 12 mmHg) in 26.6% patients (mean HVPG reduction, 3.3± 1.3 mm Hg). Etiology of cirrhosis and grade of varices were not significantly associated with CD or HVPG response. On multivariate analysis, baseline HVPG >20 mm Hg (hazard ratio [HR], 5.09; 95% confidence interval [CI], 2.909-8.926, P=0.001) and high MELD score (HR, 1.125; 95% CI, 1.066- 1.187, P=0.001) were independent predictors of CD. Conclusions: An HVPG of >20mm Hg independently predicts early and more frequent CD in compensated cirrhotics. Only a quarter of these patients respond to carvedilol and hence mandates us for careful HVPG monitoring and low threshold for additional drugs or interventions.

      • KCI등재

        Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial

        Manoj Kumar Sharma,Sumeet Kainth,Sachin Kumar,Ankit Bhardwaj,Hemant Kumar Agarwal,Rakhi Maiwall,Kapil Dev Jamwal,Saggere Muralikrishna Shasthry,Ankur Jindal,Ashok Choudhary,Lovkesh Anand,Rajender Mal 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.2

        Background/Aims: The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. Methods: Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks. Results: The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture. Conclusions: Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture.

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