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Rat에서 Paenibacillus polymyxa JB115의 병원성 및 ${\beta}$-glucan 함유 배양산물에 대한 단회 경구독성시험
정희경,강은희,챵즐치앙,홍주헌,김상달,박병권,윤효인,박승춘,Jung, Hee-Kyoung,Kang, Eun-Hee,Chang, Zhi-Qiang,Hong, Joo-Heon,Kim, Sang-Dal,Park, Byung-Kwon,Yun, Hyo-In,Park, Seung-Chun 대한수의학회 2007 大韓獸醫學會誌 Vol.47 No.4
This study was conducted to investigate the pathogenicity of Paenibacillus (R) polymyxa JB 115 and single oral dose toxicity of culture broth containing (${\beta}$-glucan (CBG-JB 115) produced from P. polymyxa JB 115 in Sprague-Dawely rats of both sexes for 14 days. After oral administration of P. polymyxa JB 115 into rats, we could not find any abnormal clinical signs and variation in the body weight and temperature as compared with control group. We also investigated the acute toxicity of CBG-JB 115. As the results, there were no clinical signs and variance in the body weight and temperature related with CBG-JB 115 in comparison with the control group. From the this experiment, we could not find out any significant pathogenicity and toxicity induced by P. polymyxa JB 115 or by CBG-JB 115. Results of this study demonstrated that consumption of P. polymyxa JB 115 and its culture broth containing (${\beta}$-glucan was not associated with any obvious signs of toxicity in Sprague-Dawely rats even following consumption of large quantities.