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MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma
Yu You,Keting Que,Yun Zhou,Zhen Zhang,Xiaoping Zhao,Jianpin Gong,Zuojin Liu 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.9
Recent studies have indicated that microRNAs (miRNAs) play an important role in hepatocellular carcinoma (HCC) progression. In this study, we showed that miR-766-3p was decreased in approximately 72% of HCC tissues and cell lines, and its low expression level was significantly correlated with tumour size, TNM stage, metastasis, and poor prognosis in HCC. Ectopic miR-766-3p expression inhibited HCC cell proliferation, colony formation, migration and invasion. In addition, we showed that miR-766-3p repressed Wnt3a expression. A luciferase reporter assay revealed that Wnt3a was a direct target of miR-766-3p, and an inverse correlation between miR-766-3p and Wnt3a expression was observed. Moreover, Wnt3a up-regulation reversed the effects of miR-766-3p on HCC progression. In addition, our study showed that miR-766-3p up-regulation decreased the nuclear β-catenin level and expression of Wnt targets (TCF1 and Survivin) and reduced the level of MAP protein regulator of cytokinesis 1 (PRC1). However, these effects of miR-766-3p were reversed by Wnt3a up-regulation. In addition, PRC1 upregulation increased the nuclear β-catenin level and protein expression of TCF1 and Survivin. iCRT3, which disrupts the β-catenin-TCF4 interaction, repressed the TCF1, Survivin and PRC1 protein levels. Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.
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Acoustic emission characterization of the fracture process in steel fiber reinforced concrete
Xiong Zhou,Yuyou Yang,Xiangqian Li,Guoqing Zhao 사단법인 한국계산역학회 2016 Computers and Concrete, An International Journal Vol.18 No.4
The correlation between the characteristics of acoustic emission signals and the strength parameters of concretes is investigated by combining the acoustic emission (AE) technique and steel fiber reinforced concrete (SFRC). By means of AE detection system, three kinds of steel fibers of varying content were used as reinforcement in concrete and their influence on the fracture process and the acoustic activity was considered in this paper. Analysis of the AE test results revealed that for different steel fiber contents, the role of steel fiber is different. Concave-convex steel fiber has an inhibitory effect on the control of crack expansion. Bow steel fiber has a better effect on the control of crack propagation when the fiber content is lower. The compressive strength of SFRC decrease when bow steel fiber content rises. Ultra-short can prevent early cracks of concrete.
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Nonlinear wind-induced instability of orthotropic plane membrane structures
Liu, Changjiang,Ji, Feng,Zheng, Zhoulian,Wu, Yuyou,Guo, Jianjun Techno-Press 2017 Wind and Structures, An International Journal (WAS Vol.25 No.5
The nonlinear aerodynamic instability of a tensioned plane orthotropic membrane structure is theoretically investigated in this paper. The interaction governing equation of wind-structure coupling is established by the Von $K\acute{a}rm\acute{a}n's$ large amplitude theory and the D'Alembert's principle. The aerodynamic force is determined by the potential flow theory of fluid mechanics and the thin airfoil theory of aerodynamics. Then the interaction governing equation is transformed into a second order nonlinear differential equation with constant coefficients by the Bubnov-Galerkin method. The critical wind velocity is obtained by judging the stability of the second order nonlinear differential equation. From the analysis of examples, we can conclude that it's of great significance to consider the orthotropy and geometrical nonlinearity to prevent the aerodynamic instability of plane membrane structures; we should comprehensively consider the effects of various factors on the design of plane membrane structures; and the formula of critical wind velocity obtained in this paper provides a more accurate theoretical solution for the aerodynamic stability of the plane membrane structures than the previous studies.
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Nonlinear wind-induced instability of orthotropic plane membrane structures
Changjiang Liu,Feng Ji,Zhoulian Zheng,Yuyou Wu,Jianjun Guo 한국풍공학회 2017 Wind and Structures, An International Journal (WAS Vol.25 No.5
he nonlinear aerodynamic instability of a tensioned plane orthotropic membrane structure is theoretically investigated in this paper. The interaction governing equation of wind-structure coupling is established by the Von Kármán\'s large amplitude theory and the D\'Alembert\'s principle. The aerodynamic force is determined by the potential flow theory of fluid mechanics and the thin airfoil theory of aerodynamics. Then the interaction governing equation is transformed into a second order nonlinear differential equation with constant coefficients by the Bubnov-Galerkin method. The critical wind velocity is obtained by judging the stability of the second order nonlinear differential equation. From the analysis of examples, we can conclude that it\'s of great significance to consider the orthotropy and geometrical nonlinearity to prevent the aerodynamic instability of plane membrane structures; we should comprehensively consider the effects of various factors on the design of plane membrane structures; and the formula of critical wind velocity obtained in this paper provides a more accurate theoretical solution for the aerodynamic stability of the plane membrane structures than the previous studies.
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