Formation Mechanisms for (Cr,Co)7C3/(Cr,Co)23C6 Heterogeneous Precipitates and Stacking Faults Around Carbides in Surfacing Welding of Stellite Alloy on Stainless Steel

Jiankun Xiong,Haibo Zhang,Fuheng Nie,Fen He,Jianping Yang,Zhan Hu,Zhongbo Wen,Haiyan Zhao,Xinjian Yuan 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

The formation mechanisms for two carbides with co-existence and increasing stacking faults nearby the carbides duringsurfacing welding were investigated in this study. The results indicated that the surfacing layer had a two-phase structure ofa matrix phase and a second phase, the density of the second phase was relatively small and the second phase was discontinuous,by contrast with the as-received welding wire. Relatively uniform microstructure of surfacing layer and the weldinginterface without melting of base metal were obtained, resulting in an inapparent change in the microhardness. A few carbideswith blocky shape were identified in the surfacing layer. The mechanisms for (Cr,Co)23C6 of face-centered cubic crystalstructure co-existing with (Cr,Co)7C3 of hexagonal close-packed crystal structure and (Cr,Co)23C6 subsequently forming closeto the pre-formed (Cr,Co)7C3 during the cooling process were discussed in alloying element, calculated equilibrium phasediagram, Gibbs energy, etc. The relatively higher density of the stacking fault present around the carbides was understoodfrom forming energy of stacking faults.

Identification of Bridge Scour Depth by Tracing Dynamic Behaviors of Superstructures

Wen Xiong,C.S. Cai,Bo Kong,Pingbo Tang,Jianshu Ye 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.4

A methodology to identify and analyze the bridge scour depth by tracing the dynamic behaviors of superstructures was developed. This proposed methodology basically relies upon the bridge scour-induced effects on the variations of two dynamic features ofsuperstructures, i.e., the natural frequency of vibration and mode of vibration. Firstly a flexibility matrix incorporating the twodynamic features is deduced for bridges under scour conditions. Then, using the scour-induced variations of such flexibility matrix, anew parameter of “[D]-based deflection change” Δδ is defined as an important index for identifying the scour depth. Such an indexΔδ is determined by both FEM (Finite Element Method) simulations and on-site measurements on the dynamic features ofsuperstructures. By doing this, the scour depths corresponding to the measured Δδ are back-deduced based on a pre-simulatedrelationship between Δδ and scour depths. A case study based on the simulation and a demonstration based on actual field data arefinally given to demonstrate the application procedure and qualitatively verify the feasibility of the proposed methodology. Thismethodology does not require any continuous and long-term bridge monitoring using underwater instrumentations and could beconveniently integrated to a routine assessment or structural monitoring system.

ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China

Wen, Yuan-Yuan,Pan, Xiong-Fei,Loh, Marie,Tian, Zhi,Yang, Shu-Juan,Lv, Si-Han,Huang, Wen-Zhi,Huang, He,Xie, Yao,Soong, Richie,Yang, Chun-Xia Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: We designed a multicenter 1:1 matched case-control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P<0.05). Conclusions: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findings may offer insight into further similar large gene-environment and gene-gene studies in this region.

Effect of Male-Sterile Cytoplasm on the Genetic Performance of Agronomic Traits in F₁ Hybrid Rices

Wen Xiong Lin,Kil-Ung Kim,Dong Hyun Shin,In-Jung Lee,Shui Lin He,Huhn-Pal Moon 韓國作物學會 1998 Korean journal of crop science Vol.43 No.2

Three different male-sterile cytoplasmic lines and their common maintainer 'Zhenshan 97B' and two elite restorer lines were used to study cytoplasmic effects on agronomic trait manifestation per se under different nitrogen supply levels. The result showed that cytoplasmic effects could be modified by nitrogen environments. The cytoplasmic effect on grain yield under 150 kg N/ha varied depending on crosses, while it was significantly negative in most crosses under both 60 and 330 kg N/ha. The correlation and path-coefficient analyses suggested that it was expected to improve cytoplasmic effects through reducing maximum tillers and increasing the percentage of productive tillers, leading to increased productive tillers and higher yield in hybrid rice by the aid of cultural practice and genetic transformation. This study also revealed that the same cytoplasm in different combinations had differential effect under the same nitrogen environment, indicating that cytoplasmic effect was produced by interaction of nuclear genes with cytoplasm rather than cytoplasm per se. These results indicated the usefulness of evaluating diverse cytoplasmic sources in various nuclear genotypes bred for hybrid rice breeding program. The finding also suggested that negative cytoplasmic effect could be effectively overcome by elite restorer lines through the interaction of nuclear genes with female cytoplasm.

Quality of Life for Patients with Esophageal/Gastric Cardia Precursor Lesions or Cancer: A One-year Prospective Study

Wen, Ying,Pan, Xiong-Fei,Huang, Wen-Zhi,Zhao, Zhi-Mei,Wei, Wen-Qiang,Chen, Feng,Lan, Hui,Huang, He,Yang, Chun-Xia,Qiao, You-Lin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Background: The current study examined health-related quality of life (QoL) for patients with esophageal/gastric cardia precursor lesions or cancer before and after treatment to facilitate improved prevention and treatment. Materials and Methods: Patients with different stages of esophageal/gastric cardia lesions completed two QoL questionnaires, EORTC QLQ-C30 and supplemental QLQ-OES 18, before primary treatment, and at 1, 6 and 12 months after treatment. Results: Fifty-nine patients with precursor lesions, 57 with early stage cancer, and 43 with advanced cancer responded to our survey. Patients with precursor lesions or early stage cancer reported better QoL overall than those with advanced cancer before treatment (p<0.01). Global QoL scores before treatment and at 1 month after treatment were $71{\pm}9$ versus $69{\pm}9$ (p>0.01), $71{\pm}8$ versus $61{\pm}11$ (p<0.01), $67{\pm}11$ versus $62{\pm}9$ (p<0.01) for three stages of lesions. At 6 months after treatment, some QoL measures recovered gradually in precursor lesion and early cancer patients, while some continuously deteriorated in advanced cancer patients. At 12 months, all QoL scores were comparable to baseline for patients with precursor lesions (p>0.01), while global QoL, social, pain, and insomnia scores for early stage and advanced cancer were inferior to corresponding baseline levels (difference between means>5, p<0.01). At this time point, compared with patients with early stage cancer, those with advanced cancer showed worse QoL with all function and most symptom measures (p<0.01). Conclusions: Patients with precursor lesions or early stage esophageal/gastric cardia cancer show better QoL than those with advanced cancer. This indicates that screening, early diagnosis and treatment may improve the QoL for esophageal/gastric cardia cancer patients. Target intervention and counseling should be given by health care providers during treatment and follow-up to facilitate QoL improvement.

Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells

Xiong, Wei,Jiang, Yong-Xin,Ai, Yi-Qin,Liu, Shan,Wu, Xing-Rao,Cui, Jian-Guo,Qin, Ji-Yong,Liu, Yan,Xia, Yao-Xiong,Ju, Yun-He,He, Wen-Jie,Wang, Yong,Li, Yun-Fen,Hou, Yu,Wang, Li,Li, Wen-Hui Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.

Concept and Analysis of Stay Cables with a CFRP and Steel Composite Section

Wen Xiong,C.S. Cai,Rucheng Xiao,Lu Deng 대한토목학회 2012 KSCE Journal of Civil Engineering Vol.16 No.1

This paper describes the concept of a novel stay cable with a Carbon Fiber Reinforced Plastic (CFRP) and steel composite section. In this concept CFRP core conserves all the advantages of CFRP materials such as light weight and high strength, while steel coat provides protection for the CFRP core and ensures reliable anchorage performance. The steel coat can reduce cost and provide higher stiffness than CFRP materials in some length range. Following this concept, several configurations were proposed for the composite structure. Effects of the key design parameter of the proposed stay cables, namely the ratio of the CFRP section area to the whole section area, were examined through a parametric study using analytical solutions. By doing this, an appropriate range of the ρ value was suggested. Factors that can affect the appropriate range of the ρ value, including the horizontal projected length of stay cables,cable force, and pylon height (i.e., vertically projected length of stay cables), were also studied. Finally, the feasibility of the proposed stay cables was conceptually verified. It was shown that the proposed stay cables could be an excellent alternative to the pure CFRP or traditional steel stay cables.

Analytical Solution on Highway U-shape Bridges using Isotropic Plate Theory

Wen Xiong,C. S. Cai,Jianshu Ye,Ying Ma 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.6

The U-shape bridge is one of the favorite designs possessing obvious advantages in lowing construction depth, especially in densely populated areas with an existing geographical layout of the transportation. The present study has developed an analytical solution on the isotropic plate theory basis for analyzing such concrete U-shape bridges. In this solution, the U-shape bridge is structurally regarded as an elastic thin plate with a boundary condition provided by two side girders. All the mechanical performances under different vertical loads including the self-weight can be given in forms of mathematic expressions, which should come handy especially during the preliminary stage of design. After accuracy verification, a parametric study was carried out to better understand and optimize the U-shape bridges in practice. The proposed solution is proved to be a time-saving solution with sufficient accuracy especially compared to the one commonly used based on the beam theory.

Mechanical performance and design optimization of rib-stiffened super-wide bridge deck with twin box girders in concrete

Wen Xiong,Jianshu Ye,Xuemei Gai,C.S. Cai 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.48 No.3

The present study fundamentally investigated the mechanical performance of the rib-stiffened super-wide bridge deck with twin box girders in concrete, which is a very popular application to efficiently widen the bridges with normal span. The shear lag effects of the specific cross-sections were firstly studied. The spatial stress distribution and local stiffness of the bridge deck with twin box girders were then investigated under several typical wheel load conditions. Meanwhile, a comparative study for the bridge deck with and without stiffening ribs was also carried out during the investigation; thereby, a design optimization for the stiffening ribs was further suggested. Finally, aiming at the preliminary design, an approximate methodology to manually calculate the bending moments of the rib-stiffened bridge deck was analytically proposed for engineers to quickly assess its performance. This rib-stiffened bridge deck with twin box girders can be widely applied for concrete (especially concrete cable-stayed) bridges with normal span, however, requiring a super-wide bridge width due to the traffic flow.

Effect of Male-Sterile Cytoplasm on the Genetic Performance of Agronomic Traits in $F_1$ Hybrid Rices

Lin, Wen-Xiong,Kim, Kil-Ung,Shin, Dong-Hyun,Lee, In-Jung,He, Shui-Lin,Moon, Huhn-Pal The Korean Society of Crop Science 1998 Korean journal of crop science Vol.43 No.2

Three different male-sterile cytoplasmic lines and their common maintainer 'Zhenshan 97B' and two elite restorer lines were used to study cytoplasmic effects on agronomic trait manifestation per se under different nitrogen supply levels. The result showed that cytoplasmic effects could be modified by nitrogen environments. The cytoplasmic effect on grain yield under 150 kg N/ha varied depending on crosses, while it was significantly negative in most crosses under both 60 and 330 kg N/ha. The correlation and path-coefficient analyses suggested that it was expected to improve cytoplasmic effects through reducing maximum tillers and increasing the percentage of productive tillers, leading to increased productive tillers and higher yield in hybrid rice by the aid of cultural practice and genetic transformation. This study also revealed that the same cytoplasm in different combinations had differential effect under the same nitrogen environment, indicating that cytoplasmic effect was produced by interaction of nuclear genes with cytoplasm rather than cytoplasm per se. These results indicated the usefulness of evaluating diverse cytoplasmic sources in various nuclear genotypes bred for hybrid rice breeding program. The finding also suggested that negative cytoplasmic effect could be effectively overcome by elite restorer lines through the interaction of nuclear genes with female cytoplasm.