Heart Disease Prediction System Using Data Mining and Hybrid Intelligent Techniques : A Review

J.Vijayashree,N. Ch. Sriman Narayana Iyengar 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.4

Heart disease is one of the main sources of demise around the world and it is imperative to predict the disease at a premature phase. The computer aided systems help the doctor as a tool for predicting and diagnosing heart disease. The objective of this review is to widespread about Heart related cardiovascular disease and to brief about existing decision support systems for the prediction and diagnosis of heart disease supported by data mining and hybrid intelligent techniques.

Cloud Based Virtual Reporting Application

J. Vijayashree,J. Jayashree,Wang Kai,Yang Zhenning,Ronnie D. Caytiles,N.Ch.S.N. Iyengar 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.11

Cloud computing is a very powerful concept that can be used to enhance the next generation data center and allow service provider to use data center capability provided by cloud and develop the application based on user requirement. This work aims to develop an android based web application namely Cloud based Virtual Reporting Application (VRA) wherein the database is stored on the cloud which resembles large storage facility. VRA is basically an android application which can be used by managers of the organization to monitor their employees. It is one kind of employee monitoring application where the manager can monitor the location of the employee and keep track of the his location whether the employee has done the allocated work or not. The app makes use of GPS technology available in the mobile phone to monitor the location. In addition to this, OPENCV library is used for face recognition to verify the authentication of the employee.

Architecture for Mobile Cloud Computing via Middle-Ware Technologies

Zhang Liuyang,J. Vijayashree,J. Jayashree,Ronnie D. Caytiles,N. Ch. S. N. Iyengar 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.12

Mobile devices are playing a vital role in information processing systems in day to day life. Current trend suggests that smart phones are going to be the first-most computing devices which many people will carry with them for maximum time everywhere. However, smart phones are still lacking behind the essential resources. This demands the need for Mobile Cloud Computing, where the key elements of data storage and data processing are carried outside the mobile devices. So this provides flexibility to mobile users as, the application and the data stored remotely can be accessed on-the-fly with high speed networks. Variation among the mobile network on basis of elements such as, bandwidth, unstable network and its uncertain availability are barriers for Quality Of Services in the performance. Thus the solution is to connect the mobile devices heterogeneously where they work collaboratively as resource providers. Our mechanism suggest for “Mobile to Hub to Cloud” model which can tackles the network disparity problem. A scenario gives the perfect example for the need of such model, mobile users in areas with infrastructure where the costs of accessing the network is too high, such as traveler who doesn’t wished to pay high roaming charges. Thus the suggested model can evaluate the following options: storing data in mobile hubs and improving the message delivery performance. So as in our example, traveler now can push the data onto the mobile buffers or hubs which in turn will send it to the cloud server.

Analysis and Issues in Cloud Operating System

Debasree Basu,Indusai G,J.Vijayashree,J.Jayashree,Ronnie D. Caytiles,N.Ch.S.N Iyengar 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.11

The conventional operating system usually works on a particular workstation but the same when implemented on a distributed environment like cloud faces many problems. This paper analyzes and explains how does the cloud operating system works in order to resolve these problems. It also differentiates the working mechanism of both based on basic storage management service provided by the cloud. At the end it provides the issues and the future challenges faced in the cloud operating system.

In Vitro Anti-Neuroblastoma Activity of Thymoquinone Against Neuro-2a Cells via Cell-cycle Arrest

Paramasivam, Arumugam,Raghunandhakumar, Subramanian,Priyadharsini, Jayaseelan Vijayashree,Jayaraman, Gopalswamy Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

We have recently shown that thymoquinone (TQ) has a potent cytotoxic effect and induces apoptosis via caspase-3 activation with down-regulation of XIAP in mouse neuroblastoma (Neuro-2a) cells. Interestingly, our results showed that TQ was significantly more cytotoxic towards Neuro-2a cells when compared with primary normal neuronal cells. In this study, the effects of TQ on cell-cycle regulation and the mechanisms that contribute to this effect were investigated using Neuro-2a cells. Cell-cycle analysis performed by flow cytometry revealed cell-cycle arrest at G2/M phase and a significant increase in the accumulation of TQ-treated cells at sub-G1 phase, indicating induction of apoptosis by the compound. Moreover, TQ increased the expression of p53, p21 mRNA and protein levels, whereas it decreased the protein expression of PCNA, cyclin B1 and Cdc2 in a dose-dependent manner. Our finding suggests that TQ could suppress cell growth and cell survival via arresting the cell-cycle in the G2/M phase and inducing apoptosis of neuroblastoma cells.

Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma

Aditya, Jain,Smiline Girija, A.S.,Paramasivam, A.,Priyadharsini, J. Vijayashree Korea Genome Organization 2021 Genomics & informatics Vol.19 No.1

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. The present study aims to assess the gene alterations in the Wnt family of genes so as to derive an association with HNSCC. Computational approaches have been utilized for the identification of gene alterations in the Wnt family of genes. Several databases such as cBioportal, STRING, and UALCAN were used for the purpose. The frequency of alteration was high in case of Wnt family member 11 (5%). Gene amplification, deep deletions, missense and truncating mutations were observed in HNSCC patients. There was a marked difference in the gene expression profile of WNT11 between grades as well as normal samples. The survival probability measured using the Kaplan-Meier curve also presented with a significant difference among male and female subjects experiencing a low/medium level expression. The female patients showed less survival probability when compared to the male subjects. This provides the prognostic significance of the WNT11 gene in HNSCC. Taken together, the present study provides clues on the possible association of WNT11 gene alterations with HNSCC, which has to be further validated using experimental approaches.

Characterization of Vancomycin Resistant Enterococci and Drug Ligand Interaction between vanA of E. faecalis with the Bio-Compounds from Aegles marmelos

V Jayavarsha,A.S Smiline Girija,Gunasekaran Shoba,J Vijayashree Priyadharsini 대한약침학회 2023 Journal of pharmacopuncture Vol.26 No.3

Objectives: Enterococcus faecalis is a gram positive diplococci, highly versatile and a normal commensal of the gut microbiome. Resistance to vancomycin is a serious issue in various health-care setting exhibited by vancomycin resistant Enterococci (VRE) due to the alteration in the peptidoglycan synthesis pathway. This study is thus aimed to detect the VRE from the patients with root caries from the clinical isolates of E. faecalis and to evaluate the in-silico interactions between vanA and the Aegles marmelos bio-compounds. Methods: E. faecalis was phenotypically characterized from 20 root caries samples and the frequency of vanA and vanB genes was detected by polymerase chain reaction (PCR). Further crude methanolic extracts from the dried leaves of A. marmelos was assessed for its antimicrobial activity. This is followed by the selection of five A. marmelos bio-compounds for the computational approach towards the drug ligand interactions. Results: 12 strains (60%) of E. faecalis was identified from the root caries samples and vanA was detected from two strains (16%). Both the stains showed the presence of vanA and none of the strains possessed vanB. Crude extract of A. marmelos showed promising antibacterial activity against the VRE strains. In-silico analysis of the A. marmelos biocompounds revealed Imperatonin as the best compound with high docking energy (–8.11) and hydrogen bonds with < 140 TPSA (Topological polar surface area) and zero violations. Conclusion: The present study records the VRE strains among the root caries with imperatorin from A. marmelos as a promising drug candidate. However the study requires further experimentation and validation.