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- 저자 : Vetvickova (검색결과 5 건)
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${\beta}$(1-3)-D-glucan affects adipogenesis, wound healing and inflammation
Vetvicka, Vaclav,Vetvickova, Jana 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
Numerous types of ${\beta}$(1-3)-D-glucans have been isolated from almost every species of yeast, grain, and fungi. These products have been extensively studied for their immunological and pharmacological effects. In this paper we evaluated the possibility whether individual ${\beta}$(1-3)-D-glucans will have an activity in less studied areas such as adipogenesis and inflammation. Our results showed that of the tested ${\beta}$(1-3)-D-glucans, yeast-derived insoluble Glucan #300, strongly inhibited adipogenic differentiation, supported wound healing and significantly lowered skin irritation. The remaining ${\beta}$(1-3)-D-glucans were significantly less active. Taken together, our study showed that with respect to natural ${\beta}$(1-3)-D-glucans, there is a clear yes-or-no effect suggesting that highly purified and highly active ${\beta}$(1-3)-D-glucans will have pleiotropic biological impact, whereas poorly isolated and/or less active ${\beta}$(1-3)-D-glucans will have only mediocre properties.
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Effects of Glucan on Immunosuppressive Actions of Mercury
Vaclav Vetvicka,Jana Vetvickova 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5
Global cycling of mercury results in the presence of mercury salts in the environment. The well-established negative effects of mercury on the immune system led us to the study whether natural immunomodulator glucan can overcome the immunosuppressive effects of mercury. Two types of mercury, thimerosal and mercury acetate, were administered in a dose of 2–8mg/L of drinking water to mice. After 2 weeks, all mice exhibited profound suppression of both cellular (phagocytosis, natural killer cell activity, mitogen-induced proliferation, and expression of CD markers) and humoral (antibody formation and secretion of interleukin-6, interleukin-12, and interferon-γ) responses. The mice were then fed with a diet containing a standard dose of glucan. Our results showed that simultaneous treatment with mercury and glucan resulted in significantly lower immunotoxic effects of mercury, which suggests that glucans can be successfully used as a natural remedy of low-level exposure to mercury.
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β(1-3)-D-glucan affects adipogenesis, wound healing and inflammation
Vaclav Vetvicka,Jana Vetvickova 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
Numerous types of β(1-3)-D-glucans have been isolated from almost every species of yeast, grain, and fungi. These products have been extensively studied for their immunological and pharmacological effects. In this paper we evaluated the possibility whether individual β(1-3)-D-glucans will have an activity in less studied areas such as adipogenesis and inflammation. Our results showed that of the tested β(1-3)-D-glucans, yeast-derived insoluble Glucan #300, strongly inhibited adipogenic differentiation,supported wound healing and significantly lowered skin irritation. The remaining β(1-3)-D-glucans were significantly less active. Taken together, our study showed that with respect to natural β(1-3)-D-glucans, there is a clear yes-or-no effect suggesting that highly purified and highly active β(1-3)-D-glucans will have pleiotropic biological impact, whereas poorly isolated and/or less active β(1-3)-D-glucans will have only mediocre properties.
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Vaclav Vetvicka,Jana Vetvickova 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.12
Thymus species are popular spices and contain volatile oils as main chemical constituents. Recently, plant-derived essential oils are gaining significant attention due to their significant biological activities. Seven different thymus-derived essential oils were compared in our study. First, we focused on their chemical composition, which was followed up by testing their effects on phagocytosis, cytokine production, chemotaxis, edema inhibition, and liver protection. We found limited biological activities among tested oils, with no correlation between composition and biological effects. Similarly, no oils were effective in every reaction. Based on our data, the tested biological use of these essential oils is questionable.
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Immunological Effects of Yeast- and Mushroom-Derived β-Glucans
Vaclav Vetvicka,Aruna Vashishta,Sujata Saraswat-Ohri,Jana Vetvickova 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.4
Glucans have a long history as nonspecific biological modulators. We compared the effects of three different glucans on immune reactions. Using two different administrations (intraperitoneal and oral) and two different animal models, we showed that yeast-derived Betamune™ (Biorigin, São Paulo, Brazil) caused significant stimulation of phagocytic activity as well as potentiation of synthesis and release of interleukin (IL)-1, IL-2, IL-4, IL-6, IL-8, IL-13, and tumor necrosis factor-α. In addition, Betamune inhibited growth of tumor cells in vivo and affected expression of several important genes in breast cancer cells. Compared to adult mice, young animals showed different sensitivity to glucan action.
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