Mn-Ce 복합 산화물에 의한 톨루엔 촉매 산화

천태진,최성우,이창섭 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

Activity of manganese oxide supported on γ-Al₂O₃ was increased when cerium was added. Also, cerium-added manganese oxide on v-Al₂O₃ was more effective in oxidation of toluene than that without cerium. XRD result, it was observed that MnO₂+CeO₂ crystalline phases were present in the samples. For the used catalyst, a prominent feature has increased by XPS. TPRITPO profiles of cerium-added manganese oxide on γ-Al₂O₃ changed significantly increased at a lower temperature. The activity of 18.2 wt% Mn+10.0 wt% Ce/γ-Al₂O₃ increased at a lower temperature. The cerium added on the manganese catalysts has effects on the oxidation of toluene.

뇌졸중 환자의 경직 감소를 위한 경피적 전기 신경 자극술과 침술의 효과

백천호,소성욱,김희상,안경회,남상수,박선구 大韓再活醫學會 1997 Annals of Rehabilitation Medicine Vol.21 No.6

45歲 以後에 初發한 偏執症候群의 特徵

田珍淑,張煥一,李成柱 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

The 25 patients, in whom paranoid symptoms had occurred after age 45, and who had been admitted to Kyung Hee University Hospital from May 1979 to June 1984, were compared with 40 paranoid schizophrenics who had fitted to the DSM-Ⅲ diagnostic criteria, to clarify whether such syndrome should be classified to schizophrenia or a separate entity. The results were as following; 1. The male to female ratio was 0.92:1 in late paraphrenics, in contrast with 2.33:1 in control (p>0.05). 2. The age at onset was 53.6±8.0 year in late paraphrenics, in contrast with 28.1±7.6 year in control (p<0.001). 3. Majority of late paraphrenics had been ill for 2 weeks to below 6 months (48.0%), while for above 2 years in control (60.0%) (p<0.0005). 4. The late paraphrenics had been in hospital for 32.1±18.6 days on the average, in contrast with 53.4±31.3 days (p<0.01). 5. At time of admission, majority of late paraphrenics had married (68.0%) (p<0.005), in contrast with being single in control (62.5%) (p<0.0005). But divorced, separated or deceased were more in late paraphrenics (32.0%) than control (p<0.05). 6. The numbers of children of late paraphrenics were 3.8±2.0, and of control 0.8±1.4 (p<0.001). 7. Upon socioesonomic classes, majority of both patients belonged to middle class (p>0.5), and control (42.5%) belonged to lower class more than late paraphrenics (20.0%) (p>0.05). 8. The control had been admitted more frequently (2.9±2.1 times) than late paraphrenics (1.4±0.9 times) (p<0.01). 9. Both patients had schizophrenic family members most of all (each other 12.0% and 7.5%) (p>0.5), the late paraphrenics had somewhat more paranoid disorder (8.0%) than control (2.5%) (p>0.3). 10. Majority of late paraphrenics had paranoid personality trait (80.0%) (p<0.0005), in contrast with schizoid one in control (55.0%) (p<0.025). 11. Precipitating factors were present in 92.0% of late paraphrenics and 60.0% of control (p<0.01). Among the contents, family problem was most predominant (56.0%) (p<0.0005) in late paraphrenics and marital and financial problems (each other 28.0%) (p<0.05) in next order, while work (30.0%) and interpersonal problem (17.5%) were more prominent in control (p>0.5). 12. Among the contents of delusions, majority of both patients had persecutory ones (80.0%) (p>0.5) and idea of reference (each other 40.0% and 62.5%) (p>0.05). Otherwise, late paraphrenics had infidelity (36.0%) and hypochondriacal (32.0%) ones (p>0.05), while delusion of being controlled (55.0%) (p<0.01) and other Schneiderian ones (30.0%) were more common in control (p<0.05). In addition, affective symptoms (72.0%) (p<0.05) and cognitive difecit (40.0%) (p<0.0005) were more common in late paraphrenics, while hallucination (60.0%) (p>0.3) and loosening of association (67.5%) (p>0.05) in control. 13. The responses to physical treatment mainly composed of antipsychotics were fair (each other 92.0% and 100.0%) (p>0.05). Otherwise, late paraphrenics administered antidepressants (24.0%) more than the control (p<0.01), while electroconvulsive therapy was used more in control (20.0%) (p>0.1). 14. Most of the clinical diagnoses at discharge were established as paranoid disorder (56.0%) and in next order, paranoid schizophrenia (20.0%). Based on the above results, we concluded that late paraphrenia should be classified to paranoid disorder rather than atypical psychosis in addition to the agreement with the validity of separating this syndrome from schizophrenia in DSM-Ⅲ.

退行期 偏執症 患者의 自害에 依한 舌 部分切斷 1例

田珍淑,李成主,張煥一 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4

A 51 year-old male patient was admitted to Neuropsychiatric ward of Kyunghee University Hospital from April 2 to May 28 in 1984, because he amputed his tongue for himself with a tool under the psychotic state. He has been a heavy drinker with paranoid personality make-up, and lost his father when he was 10 year-old, and separated from his mother at eighteen. Recently, he lost his job and frequently troubled with his spouse, and separated from his son. Psychodynamically, guilt, separation anxiety, lowered self-esteem induced by loss of social role function which led social isolation, and using of rigid adaptation to the stressful life events were remarkable features.

한국인 강박장애와 Val-158-Met Catechol-O-Methyltransferase 유전자 다형성 간의 상관성 연구

천근아,김세주,김찬형,구민성,남윤영,박성혁,이홍식 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

목적 COMT(Catechol-O-Methyltransferase) 효소는 도파민성과 노어아드레날린성 체계의 조절에서 매우 중요한 작용을 하며 염색제 22q11에 위치해 있다. 일부의 강박장애 환자들은 도파민 차단제에 좋은 치료 반응을 보이며 이런 현상은 COMT가 강박장애의 병인론에 역할을 하고 있을 가능성을 말해준다. Val-158-Met COMT 유전자의 다형성은 효소의 감소를 유도하는 L(저활성) 대림형질, 활성의 증가를 유발하는 H(고활성) 대립형질로 알려져 있으며 L 대립형질 또는 LL 유전형이 강박장애와 연관이 있다는 보고가 있으나, 아직까지 강박장애와 COMT 다형성 사이의 연관성에 대한 연구결과들은 일관되지 않다. 따라서 본 연구에서는 한국인 강박장애 환자들을 대상으로 Val-158-Met COMT 유전자의 다형성과의 연관성을 알아보고자 하였다. 방법 2002년 3월부터 2004년도 2월까지 약 24개월동안 서울지역 일 대학병원과 경기지역 일 대학병원 강박장애 클리닉을 방문하여 강박장애로 진단받은 124명의 환자들을 연구대상으로 하였고 정상 대조군으로는 나이와 성별을 고려하여 자원자 170명이 선별되어 포함되었다. 강박장애군과 정상 대조군의 혈액으로부터 유전자 추출 후 COMT 유전자 형벌 (genotyping)을 시행하였다. 다형성을 H/H 와 H/L, L/L 유전형으로 나눈 뒤 강박장애와 정상대조군 사이의 유전자 빈도를 카이 검정법으로 비교하여 연관성을 관찰하었다. 또한 강박장애 환자들에게 시행한 YBOCS로부터 측정한 강박장애 심각도 및 Hamilton Depression Raing Scale (HDRS) 총점과 COMT 유전자 다형성 사이의 연관성을 비교하였다. 결과 본 연구 결과 한국인 강박장애와 COMT 다형성 간에는 유의한 상관성이 관찰되지 않았다. YBOCS 심각도와 COMT 유전자형과의 유의한 연관성이 관찰되지 않았다. 그러나, 강박장애 환자군들의 COMT 유전자형 세 군 사이의 우울증상 점수에서는 유의한 차이가 관찰되었다. 결론 한국인에서 강박장애와 COMT 유전자 다형성 사이에는 연관성이 없었다. 그러나, COMT의 H 대립형질과 강박장애 군에서 공존하는 우울증상 척도가 유의한 연관성을 보인 현상은 COMT 유전자의 다형성이 강박장애의 공존 우울증상에 영향을 미칠 수 있는 가능성을 시사한다고 생각된다. Objectives : The definite cause of obsessive-compulsive disorder (OCD) is still unknown. Evidences from familial, twin and segregation studies support the role of a genetic factor. There are also growing evidence indicating that OCD has specific neurochemical and neuroanatomical basis. Derived from the effectiveness of treatment with dopamine receptor blocker in certain part of OCD patients (eg. SSRI treatment-resistant OCD), several candidate genes related to dopamine dysregulation have been hypothesized to play an important role in the development of OCD. One of them is the Catechol-O-Methyltransferase (COMT) gene. The aim of this study was to investigate the association between COMT and OCD in Korean population. Methods : 124 OCD patients and 170 normal controls participated in this study. Genomic DNA was extracted from their blood. The genotypes and allele frequencies of the COMT polymorphism between OCD group and control group were compared. We investigated the association between severity of OCD assessed by Yale-Brown obsessive compulsive symptom scale (YBOCS) and Hamilton depression rating scale (HDRS) scores and COMT polymorphism. Results : In this case-control study, we could not find any association between COMT gene polymorphism and development of OCD. In OCD group, patients with H/H genotype had significantly higher scores for the HDRS than those with H/L or L/L genotype. Conclusion : In this study, there was no difference in genotype distributions of COMT between OCD and control groups. However, H/H genotype of COMT gene polymorphism might be related to depressive symptoms in OCD patients.

Mn이 첨가된 V₂O_(5)/TiO₂ 촉매상에서 질소산화물의 저온 SCR 특성

천태진,최상기,최성우 한국환경과학회 2004 한국환경과학회지 Vol.13 No.6

V₂O_(5)/TiO₂ catalysts promoted with Mn were prepared and tested for selective catalytic reduction of NOx in NH3. The effects of promoter content, degree of catalyst loading were investigated for NOx activity while changing temperatures, mole ratio, space velocity and O₂ concentration. Among the various V₂O_(5) catalysts having different metal loadings, V₂O_(5)(l wt.%) catalyst showed the highest activity(98%) under wide temperature range of 200-250 C. When the V₂O_(5) catalyst was further modified with 5 wt.% Mn as a promoter, the highest activity(90-47%) was obtained over the low temperature windows of 100-2000. From Mn-V₂O_(5)/TiO₂, it was found that by addition of 5 wt.% Mn on V₂O_(5)/TiO₂ catalyst, reduction activity of catalyst was improved, which resulted in the increase of catalytic activity and NOx reduction. According to the results, NOx removal decreased for 10%, but the reaction temperature down to 100℃.

정신분열병 환자에서 Haloperidol이 99m-Tc-ECD SPECT로 측정한 국소뇌혈류량에 미치는 영향

천근아,이종두,민성길,김세주,안석균 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 정신분열병 환자에서의 뇌혈류량은 약리학적 상태를 포함한 다양한 요소들에 의하여 영향을 받는다. 항정신병약물이 국소뇌혈류량에 미치는 영향에 관한 많은 연구가 행해져 왔으나 항정신병약물의 종류와 노출기간, 약물용량의 차이로 인해 다양하고도 상반된 결과를 보여왔다. 따라서 본 연구에서는 정신분열병 환자에서 항정신병약물의 종류와 노출기간을 통제한 상태에서 약물 투여시 국소뇌혈류량의 변화를 관찰하고자 하였다. 방 법 : 항정신병약물 비노출(antipsychotic drug-naive) 정신분열병 환자 18명과 haloperidol을 투여받은 환자 19명을 대상으로 안정 상태(resting state)에서 SPECT를 촬영하여 국소뇌혈류량을 측정한 후 두군 사이의 상대적 뇌혈류량을 비교하였다. Haloperidol은 D2 수용체에 비교적 선택적으로 작용하고 활성대사산물이 적기 때문에 실험약물로 선택되었고 약물노출기간은 1∼3주동안으로 제한하였다. 결 과 : 우측 저측두엽, 좌측 저전두엽, 좌·우측 기저신경절, 좌측 시상에서의 상대적 평균 혈류지표는 halo-peridol 투여군에서 비노출군에 비해 유의하게 증가되어 있었다. 또한 좌·우측 두정-후두엽과 우측 두정엽에서의 상대적 평균 혈류지표도 haloperidol 투여군에서 비노출군에 비해 유의하게 증가되어 있었다. 반면 좌측 저측두엽의 상대적 평균 혈류지표는 haloperidol 투여군에서 항정신병약물 비노출군에 비해 유의하게 감소되어 있었다. 그러나 우측 저전두엽, 우측 시상, 좌·우측 고측두엽, 좌·우측 고전두엽, 좌측 두정엽에서 두 군 사이의 상대적 평균 혈류지표는 유의한 차이를 보이지 않았다. 결 론 : 정신분열병 환자에서 항정신병약물이 국소뇌혈류량에 영향을 미치며, 항정신병약물 투여상태가 뇌혈류량 측정시 고려되어야할 중요한 변수임을 시사한다. Objectives : Regional cerebral blood flow(rCBF) in schizophrenics is confounded by various factors including medication status. Previously, there have been numerous studies regarding the effects of antipsychotics on rCBF. However, these works have shown contradictory and inconsistent findings due to the different of type, dose and exposed duration of antipsychotics. The aim of this study was to observe the effect of antipsychotic medication on rCBF and exposed duration of antipsychotics under control. Methods : Eighteen drug-naive schizophrenics and 19 schizophrenics medicated with halo-peridol were included in the study. Regional cerebral blood flow was assessed with single-photon emission computed tomography(SPECT) under a resting state. Relative rCBF was compared between two groups. Haloperidol was selected as the antipsychotic drug as it has relatively selective action at the D2 receptor and less active metabolites. Exposed duration was limited from one to three weeks. Results : Haloperidol-medicated schizophrenic patients had a significantly greater increase of relative cerebral perfusion in the right inferior temporal lobe, left inferior frontal lobe, both basal ganglia, left thalamus, both parieto-occipital lobes, and right parietal lobe than drug-naive schizophrenic patients. Haloperidol-medicated schizophrenic patients had a significant decrease of relative cerebral perfusion in left inferior temporal lobe. However, no significant differences in relative rCBF were found between drug-naive and haloperidol-medicated schizophrenic patients in right inferior frontal lobe, right thalamus, both superior temporal lobes, both superior frontal lobes, and left parietal lobe. Conclusion : These findings suggest that antipsychotics affect regional cerebral blood flow, and antipsychotic medication status must be considered in the relative rCBF studies of schizophrenic patients.

영어형태론연구 : 복합어를 중심으로 Chiefly on the Compound Formation

田相範 서울대학교 어학연구소 1988 語學硏究 Vol.24 No.3

The purpose of this paper is to criticize Roper and Siegel (1978) and to propose a compound formation rule for English. Roeper and Siegel make distinction between root and verbal compounds, and to derive the latter they propose the First Sister Principle. This principle, however, is shown to be both too strong and too weak. To derive English compound nouns, it is proposed to concatenate any kind of lexically independent nouns. The overgenerated output will be filtered by several output constraints, such as phonological, morphological, and semantic. The First Sister Principle will be used as a semantic filter and the semantic interpretation of the output compound nouns will also be done by the Variable R Condition proposed by Allen (1978). The level mechanism proposed in Lexical Phonology will be used as a well-formedness condition as in Sproat (1985).

Aspergillus sp. ISR 균주를 통한 콜레스테롤 합성저해제 lovastain의 생산

박상은,조미현,신동화,황승환,박천석 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-

본 연구에서 한국 토양에서 분리된 lovastatin 생산 균주인 Aspergillus sp. ISR 균주를 이용하여 여러 배지 조성 성분이 lovastatin의 생산에 미치는 영향을 관찰하였다. 탄소원으로는 lactose보다 glycerol 5%가 가장 효과적이었으며 질소원과 인산염의 경우는 기본 RPM배지 조성과 농도에서 보다 효과적인 것을 발견하지 못하였다. 복합영양원으로 rapeseed meal 보다는 대두박이 보다 효과적이어서 저렴한 배지원으로 사용이 가능할 것으로 사료된다. 최종적으로 최적화된 배지를 사용하여 52 mg·L^(-1)의 lovastatin을 생산할 수 있었고 이는 기존의 RPM 배지보다 수율이 4.5배 증가한 것이다. 좀 더 효과적인 lovastatin의 생산을 위하여 회분식 발효에 대한 연구와 분자유전학적인 연구를 통한 고생산 균주의 제조에 대한 연구가 진행중이다. Effects of various nutritional components on the production of lovastatin were investigated in the Aspergillus sp. ISR. Among various carbon (C) sources, glycerol was determined to be the most effective C source at the concentration of 5% (v/v). In case of nitrogen sources, 0.2% (w/v) KNO_(3) efficiently induced the lovastatin production in Aspergillus sp. ISR. Interestingly, the addition of soybean meal into the production medium enhanced the lovastatin production compared to the rapeseed meal. Conclusively, Aspergillus sp. ISR produced 52 mg·L^(-1) of lovastatin in the optimized medium containing 5% (v/v) glycerol, 0.2% (w/v) KNO_(3), 0.3% (w/v) KH_(2)PO_(4), and 0.3% (w/v) soybean meal, which was 4.5 times higher than the amount produced using the standard RPM (rapeseedmeal production medium).

최적형상의 고속용 엔드밀 설계를 위한 프로그램 개발

고성림,한창규,서천석,김경배 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

The tool geometry parameters and cutting process have complex relationships. Until now, various cutting test were needed to acquire optimal design of end mill for the purpose of high speed machining, due to the insufficient knowledge about cutting process in high speed machining. Using various tools with differentgeometry, relationships between tool geometry parameter (rake angle, clearance angle, length of cutter) and cutting process (cutting force, surface accuracy, surface roughness) have been studied. Acquired data can be used to design optimal tool for high speed machining