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孫菊培,孫基燮 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2
Authors summarized and analyzed for 229 patients with thyrod nodules, admitted and operated at the department of general surgery, medical college of Chungnam national university. The results were as follows. 1. Benign nodules prevalent in the third decade, 49 cases (28.8%) and fifth decade, 50 cases (29.4%) and malignant in the fourth decade 20 cases (37.7%) and fifth deeade 12 cases (22.0%). Sex distribution revealed preponderance of female to male with the ratio of 11.7:1. 2. The duration of illness was 3 months is most common in 55 cases, 24.0% and one year in 97 cases, 42.4%. 3. The most common size was 2㎝-3㎝ in 102 caess, 44.5% and almost all palients, 204 cases, 89.0%, had nodules less than 4㎝ in size 4. Almost all patients, 206 cases, 90.0%, had a solitary nodule and most prevalent consistency were hard in 105 cases, 45.9%. 5. The pathologic classification in the excised thyroid nodules in benign categories, were adenomatous goiter 143 cases (84.1%), and follicular adenoma 19 cases (11.1%), and in malignant categories, papillary cancer 39 cases (73.6%), follicular cancer 12 cases (22.6%), and medullary cancer 2 cases (5.8%). 6. In finding of radioiodide scan cold nodules were identified in 57 eases (42.2%), and hot nodles in 78 cases (57.8%). 7. The most common symptoms and signs were palpable mass in all patients and toxic symptoms. has identified in 84 cases (32.0%), and pressure symptoms in 12 cases (4.6%). 8. The most prevalent symptom of toxic symptoms was palpitation in 43 cases (27.7%), and easy fatigabiility and general malaise in 38 cases (24.5%). 9. The most commonly performed surgical procedure was unilateral lobectomy in 125 cases (54.5%), right lobectomy in 63 cases (32.3%), and left lobectomy in 43 cases (32.2%, and subtotal thyroidectomy in 55 cases (24.0%), followed it.
신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예
이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4
저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.
On Simple Closed Curves on the Boundary of a 3-manifold
Son,Kuk-Hyeon,Lee,Jaeik 東西大學校 1996 동서논문집 Vol.2 No.1
This paper deals with simple closed curves in the boundary of a 3-manifold which are concerned with incompressibility of certain surfaces. Main theorems will provide us useful geometric tools in the study of incompressibility and irreducibility in 3-manifolds obtained by attaching 2-handles.
( Kuk-kyung Son ),( Heon-seock Cynn ),( Ji-hyun Lee ),( Dong-hwan Park ),( Bo-been Kim ) 대한물리의학회 2019 대한물리의학회지 Vol.14 No.2
PURPOSE: Forward head posture (FHP) is a head-on-trunk malalignment that results in musculoskeletal dysfunction and neck pain. To improve forward head posture, both the craniocervical flexion exercise (CCFE) and the visual guide (VG) technique have been used. This study compared the immediate effects of CCFE and VG combined with CCFE on craniovertebral angle (CVA), as well as on the activity of the sternocleidomastoid (SCM) and anterior scalene (AS) muscles during CCFE in subjects with FHP. METHODS: In total, 16 subjects (nine males, seven females) with FHP were recruited using the G-power software. Each subject conducted CCFE and CCFE combined with VG in random order. The CVA was recorded using a digital camera and the ImageJ image analysis software. The EMG data of SCM and AS were measured by surface electromyography. A paired T-test was used to assess differences between the effects of the CCFE and VG combined with CCFE interventions in the same group. RESULTS: The CVA was significantly greater for CCFE combined with the VG than for CCFE alone (p<.05). The activity of the SCM and AS muscles was also significantly greater when the VG was combined with CCFE than during CCFE alone across all craniocervical flexion exercise phases (p<.05). CONCLUSION: Use of the VG technique combined with CCFE improved FHP in subjects with FHP compared to CCFE alone.
Carbon nanotubes as cancer therapeutic carriers and mediators
Son, Kuk Hui,Hong, Jeong Hee,Lee, Jin Woo DOVE MEDICAL PRESS 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.</P>