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Daniel Scheiber,Tomas Jelenik,Elric Zweck,Patrick Horn,Heinz-Peter Schultheiss,Dirk Lassner,Udo Boeken,Diyar Saeed,Malte Kelm,Michael Roden,Ralf Westenfeld,Julia Szendroedi 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
The lifetime risk of developing heart failure is approximately 20%, and survival rates remain poor. Myocardial mitochondrial function has been suggested to play a pivotal role in heart failure pathophysiology. Human studies on ex vivo mitochondrial function have mostly been limited to atrial tissue obtained during open heart surgery and have provided contradictory results. This study aimed at measuring myocardial mitochondrial function in transcatheter ventricular endomyocardial biopsies and assessing the relationship between oxidative capacity and heart function. We enrolled 40 heart failure patients undergoing ventricular assist device surgery or heart transplantation (34 males, age 57 ± 11 years, body mass index 26.6 ± 4.8 kg/m2) and 29 heart transplant recipients of comparable age and body mass index with normal left ventricular function undergoing surveillance biopsies (23 males, 57 ± 12 years, body mass index 26.2 ± 4.1 kg/m2). High-resolution respirometry was established in the myocardium to measure oxidative capacity ex vivo. The mitochondrial oxidative capacity was 90% higher in ventricular compared to atrial tissues (n = 11, p < 0.01) of explanted hearts. Respiration rates were comparable in ventricular samples of heart failure patients obtained during open heart surgery by standard tissue preparation or ex vivo endomyocardial biopsy (r = 0.9988, p < 0.0001, n = 8), and the mitochondrial oxidative capacity in samples from these patients remained stable for 8 h when stored in either of two common preservation buffers. The oxidative capacity was 44% lower in heart failure than in transplant recipients (67 ± 3 vs. 97 ± 5 pmol/[s mg], p < 0.0001) and correlated positively with heart function (r = 0.49, p < 0.01). High-resolution respirometry of ventricular tissue is feasible in transcatheter biopsies, facilitating clinical studies on myocardial mitochondrial function in patients not undergoing heart surgery.
개에서의 피부, 피부조직학, 임상병리학 및 갑상선 기능에 있어서 지방산 농도에 관한 규정식 중 다양한 단백질들의 제반 영향(6)
White Stephen D.,Rosychuk Rod A.W.,Scott Kathryn V.,Carey Daniel P.,Longardner Curtis,Schultheiss Patricia C.,Salman Mowafak 대한수의사회 1997 대한수의사회지 Vol.33 No.1
12마리의 개들을 12주동안 6종류의 규정식으로 각각 급여시켰다. 규정식들은 단지 단백질원 즉 닭고기, 새끼양의 고기, 물고기, 쇠고기 및 콩이란 것에서만 차이가 있었다. 개들은 CBC 즉, 혈청화학프로필, 요분석, TSH반응시험 및 피부생검을 통하여 평가하였다. 피부생검은 조직학적으로 하는 것과 피부지방산 농도의 측정을 통한 평가, 두가지 방법으로 평가하였다. 평가된 지방산들은 리롤레산, 감마-리롤렌산, 알파-리롤렌산, 아라키돈산, 아이코사테트라에노이산 및 아이코사펜타에노이산 등이었다. 개들은 주관적으로 생검채취부위에서 털의 재성장과 비늘(피부의 얇은 조각)의 존재유무로 평가하였다. 결과에서 보면 각종의 규정식을 급여시킨 개들 사이에서 CBS, 조직적 소견 또는 피부지방산 수치에서 차이가 나타나지 않았다. 쇠고기 규정식을 급여시킨 12마리중 3마리의 개에서 고콜레스테롤 혈증이 있었고, 콩 규정식을 급여시킨 12마리중 9마리의 개에서 알카리성 오줌과 돼지고기를 급여시킨 12마리중 4마리가 비늘이 주관적 증가가 있었고, 털의 재성장이 감소된 것으로 나타났다.
A 57-MHz CW RFQ for the AEBL Project
D.L. Schrage,A. Barcikowski,A.A. Kolomiets,B. Rusthoven,B. Clifft,F. DePaola,G. Waldschmidt,J.W. Rathke,M. Bracken,N.E. Vinogradov,P.N. Ostroumov,S. Sharma,S.I. Sharamentov,T. Schultheiss,W. F. Toter 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.I
The Advanced Exotic Beam Laboratory (AEBL) at the Argonne National Laboratory (ANL) will provide a research facility for studies of nuclear phenomena by using beams of short-lived isotopes for research in the nature of nucleonic matter, the origin of the elements, tests of the Standard Model along with applications in medicine, industry, and other applied physics research. The proposed design of the AEBL driver linac evolved from the Rare Isotope Accelerator (RIA) project. It is a CW 850 MV linac capable of accelerating uranium ions up to 200 MeV/u and protons to 570 MeV with 400 kW beam power. The first section of the linac is a 57 MHz pseudo split coaxial CW Radio Frequency Quadrupole (RFQ) linac. This is followed by 221 superconducting cavities of various types. A section of the RFQ linac was fabricated and tested under R\&D funding for the RIA Project. This is the first section of the six-section, 392 cm RFQ linac. This paper describes the design, fabrication, and testing of this RFQ.