Formulation of Ceftriaxone Conjugated Gold Nanoparticles and Their Medical Applications against Extended-Spectrum β-Lactamase Producing Bacteria and Breast Cancer

( Sanaa M. F. Gad El-rab ),( Eman M. Halawani ),( Aziza M. Hassan ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.9

Gold nanoparticles (AuNP) and their conjugates have been gaining a great deal of recognition in the medical field. Meanwhile, extended-spectrum β-lactamases (ESBL)-producing bacteria are also demonstrating a challenging problem for health care. The aim of this study was the biosynthesis of AuNP using Rosa damascenes petal extract and conjugation of ceftriaxone antibiotic (Cef-AuNP) in inhibiting ESBL-producing bacteria and study of in vitro anticancer activity. Characterization of the synthesized AuNP and Cef-AuNP was studied. ESBLproducing strains, Acinetobacter baumannii ACI1 and Pseudomonas aeruginosa PSE4 were used for testing the efficacy of Cef-AuNP. The cells of MCF-7 breast cancer were treated with previous AuNP and Cef-AuNP at different time intervals. Cytotoxicity effects of apoptosis and its molecular mechanism were evaluated. Ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy established the formation of AuNP and Cef-AuNP. Transmission electron microscope demonstrated that the formed nanoparticles were of different shapes with sizes of 15~35 nm and conjugation was established by a slight increase in size. Minimum inhibitory concentration (MIC) values of Cef-AuNP against tested strains were obtained as 3.6 and 4 μg/ml, respectively. Cef-AuNP demonstrated a decrease in the MIC of ceftriaxone down to more than 27 folds on the studied strains. The biosynthesized AuNP displayed apoptotic and time-dependent cytotoxic effects in the cells of MCF-7 at a concentration of 0.1 μg/ml medium. The Cef-AuNP have low significant effects on MCF-7 cells. These results enhance the conjugating utility in old unresponsive ceftriaxone with AuNP to restore its efficiency against otherwise resistant bacterial pathogens. Additionally, AuNP may be used as an alternative chemotherapeutic treatment of MCF-7 cancer cells.

Applications of interval \textit{t}-norm fuzzy ideals of hemirings with interval valued characteristic function

Sanaa Anjum,Bilal Ahmad,Tasawar Abbas 원광대학교 기초자연과학연구소 2020 ANNALS OF FUZZY MATHEMATICS AND INFORMATICS Vol.20 No.1

This communication reports the notions of interval t-norm fuzzy subhemirings, interval t-norm fuzzy ideals, quasi ideals, bi ideals, interior ideals and generalized bi ideals of hemirings with interval valued characteristic function. Some examples of such ideals are also discussed.

Morphology of cat vomeronasal organ non-sensory epithelium during postnatal development

Sanaa A. M. Elgayar,Heba M. Saad-Eldin,Ola A. Haussein 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.1

The vomeronasal organ has an important role in mammal’s social and sexual behaviours. In addition, it mediates defensive behavior through detection of protein pheromone homologues. In this work, a detailed morphological description of the postnatal development of the non-sensory epithelium (NSE) lining the vomeronasal duct (VND) of the female cat is provided using various histological techniques. The study focused on newborn, 2 weeks, 4 weeks, and 8 weeks of postnatal ages using four animals for each age. We report here for the first time that three types of NSE line the rostral segment of the VND; nonkeratinized stratified squamous epithelium, stratified cuboidal epithelium, and ciliated pseudo stratified columnar ciliated epithelium with goblet cells and that the VND undergoes 90° a change in its its axis from the vertical position caudally to the horizontal position rostral. The NSE which lines the lateral side of the VND middle segment is consists of cliated pseudostratified columnar epithelium without goblet cells. In addition to basal cells, the NSE contains ciliated and three types of nonciliated columnar epithelial cells (dark, light, and unstained). Mitotic figures were observed only in the basal cells layer during the first 2 weeks of postnatal development. Intraepithelial invading inflammatory cells were uncommon. Scanning electron microscopy revealed unevenly distributed long cilia intermingled with microvillar processes and intervening short microvillar processes. These projecting cilia and microvilli revealed a gradual increase in their height during development toward maturity.

Green Synthesis of Copper Nano-Drug and Its Dental Application upon Periodontal Disease-Causing Microorganisms

( Sanaa M. F. Gad El-rab ),( Sakeenabi Basha ),( Amal A. Ashour ),( Enas Tawfik Enan ),( Amal Ahmed Alyamani ),( Nayef H. Felemban ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.12

Dental pathogens lead to chronic diseases like periodontitis, which causes loss of teeth. Here, we examined the plausible antibacterial efficacy of copper nanoparticles (CuNPs) synthesized using Cupressus macrocarpa extract (CME) against periodontitis-causing bacteria. The antimicrobial properties of CME-CuNPs were then assessed against oral microbes (M. luteus. B. subtilis, P. aerioginosa) that cause periodontal disease and were identified using morphological/ biochemical analysis, and 16S-rRNA techniques. The CME-CuNPs were characterized, and accordingly, the peak found at 577 nm using UV-Vis spectrometer showed the formation of stable CME-CuNPs. Also, the results revealed the formation of spherical and oblong monodispersed CME-CuNPs with sizes ranged from 11.3 to 22.4 nm. The FTIR analysis suggested that the CME contains reducing agents that consequently had a role in Cu reduction and CME-CuNP formation. Furthermore, the CME-CuNPs exhibited potent antimicrobial efficacy against different isolates which was superior to the reported values in literature. The antibacterial efficacy of CME-CuNPs on oral bacteria was compared to the synergistic solution of clindamycin with CME-CuNPs. The solution exhibited a superior capacity to prevent bacterial growth. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and fractional inhibitory concentration (FIC) of CME-CuNPs with clindamycin recorded against the selected periodontal disease-causing microorganisms were observed between the range of 2.6-3.6 μg/ml, 4-5 μg/ml and 0.312-0.5, respectively. Finally, the synergistic antimicrobial efficacy exhibited by CME-CuNPs with clindamycin against the tested strains could be useful for the future development of more effective treatments to control dental diseases.

How Investment Deposits at Islamic and Conventional Banks Effect Earnings Per Share?

Sanaa Nazami MASWADEH 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11

The study aims to compare the effects of employing investment deposits (joint and specified investment deposits) in Islamic banks, and investment deposits (term deposits and deposits with notification) at conventional banks, on shareholders’ profitability, represented by the earnings per share (EPS), in light of operational profits as a controlling variable. Data related to the study variables was collected from the annual financial reports published by the study sample banks, during the period (2009-2018). The study relies on multiple regression to test the hypotheses of the study. The high adjusted R² to explain the change in EPS for Islamic banks model as compared to conventional banks, is a result of the high difference between investment deposits (specified and joint) at Jordanian Islamic banks and investment deposits (term deposits and deposits with notification) at Jordanian conventional banks. The study found that it is important for the managements of Islamic banks to adopt a uniform method to combine speculative funds, in order to develop and improve shareholders’ profitability. The study recommended Islamic banks to follow practical, methodological and transparent approaches to calculate the rates of Murabaha profit margins between shareholders and depositors, while also taking into consideration some of the issues which could be harmful for the competition between Islamic and conventional banks.

Nicotine impact on rat substantia nigra compacta

Sanaa A M Elgayar,Ola A Hussein,Heba A Mubarak,Amany M Ismaiel,Asmaa M.S. Gomaa 대한해부학회 2021 Anatomy & Cell Biology Vol.54 No.1

Nicotine neuronal interactions exert an adverse potential in some brain regions and a significant link has been established between tobacco smoke/nicotine and vascular impairment. This work addresses nicotine impact on various components of the substantia nigra compacta (SNc) in rat. Twenty adult male Albino rats were divided equally into two groups: Group I, vehicle-control group (received saline [1 ml/kg body weight intra peritoneally] for 11 days). Group II; nicotine group (received 1.5 mg/kg body weight/day Sc) for 11 days. Nicotine levels were detected in the serum. Specimens were taken from the mid brain, processed and examined using biochemical, immunohistochemical, ultrastructural and morphometric techniques. In nicotine group, biochemical analysis revealed reduction in total antioxidant capacity (TAC), decrease in dopamine and malondialdehyde (MDA) levels. The mean number of light cells, and the mean surface area of nerve cells/field were significantly reduced, with an increase of dark cells were found in nicotine group compared to control. Immunoreactivity in nicotine group revealed an increase in neuronal α-synuclein, reduction in tyrosine hydroxylase enzyme, an increase in caspase 3 and ultrastructure changes suggestive of neuronal apopto. The blood capillaries were markedly affected. Nicotine induced endothelial and pericytic apoptotic changes, irregular lumena and indistinct endothelial junctional complex. Nicotine administered subcutaneously in a small dose may have a deleterious effect on SNc, mainly involving dopaminergic neurons and blood capillaries. This effect seems to be secondary to an oxidative stress that might be produced by reduced TAC and increased MDA levels.

The Effect of Computerized Tax Services in Improving Tax Performance Moderated by Governance

MASWADEH, Sanaa Nazami,HANANDEH, Tariq Samih Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12

This study aims to evaluate the effect of computerized tax services in improving tax performance by moderating governance principles in Jordanian tax income departments. The study is based on a questionnaire distributed to income tax auditors, who were chosen by the simple random sampling method, so that 170 questionnaires were subjected to statistical analysis. The study models were formulated in the form of simple and multiple regression equations to test the hypotheses of the study, in addition to relying on One Sample T-test to calculate the mean of questionnaire answers. The most prominent research results is that the application of tax governance principles through the provision of computerized tax services is reflected in the increase in confidence between taxpayers and income tax departments, the efficiency of tax performance, and tax proceeds. Also, the study pointed out the importance of the income tax departments to prepare strategic plans regarding the development and the follow-up of modern technologies related to computerized tax services. It especially regards linking and collecting tax from taxpayers such as via electronic tax payment and collection system, in order to ensure the speed of completion, accuracy of calculation, and raising the efficiency of tax performance.

The Electrochemical Behavior of Ni-base Metallic Glasses Containing Cr in H₂SO₄ Solutions

Arab, Sanaa.T.,Emran, Khadijah.M.,Al-Turaif, Hamad A. Korean Chemical Society 2012 대한화학회지 Vol.56 No.4

In order to develop alloy resistance in aggressive sulphat ion, the corrosion behavior of metallic glasses $Ni_{92{\cdot}3}Si_{4.5}B_{32}$, $Ni_{82,3}Cr_7Fe_3Si_{4.5}B_{3.2}$ and $Ni_{75.5}Cr_{13}Fe_{4.2}Si_{4.5}B_{2.8}$ (at %) at different concentrations of $H_2SO_4$ solutions was examined by electrochemical methods and Scanning Electron Microscope (SEM) and X-ray Photoelectron Microscopy (XPS) analyses. The corrosion kinetics and passivation behavior was studied. A direct proportion was observed between the corrosion rate and acid concentration in the case of $Ni_{92{\cdot}3}Si_{4.5}B_{32}$ and $Ni_{75.5}Cr_{13}Fe_{4.2}Si_{4.5}B_{2.8}$ alloys. Critical concentration was observed in the case of $Ni_{82,3}Cr_7Fe_3Si_{4.5}B_{3.2}$ alloy. The influence of the alloying element is reflected in the increasing resistance of the protective film. XPS analysis confirms that the protection film on the $Ni_{92{\cdot}3}Si_{4.5}B_{32}$ alloy was NiS which is less protective than that formed on Cr containing alloys. The corrosion rate of $Ni_{82,3}Cr_7Fe_3Si_{4.5}B_{3.2}$ and $Ni_{75.5}Cr_{13}Fe_{4.2}Si_{4.5}B_{2.8}$. alloys containing 7% and 13% Cr are $7.90-26.1{\times}10^{-3}$ mm/y which is lower about 43-54 times of the alloy $Ni_{92{\cdot}3}Si_{4.5}B_{32}$ (free of Cr). The high resistance of $Ni_{75.5}Cr_{13}Fe_{4.2}Si_{4.5}B_{2.8}$ alloy at the very aggressive media may due to thicker passive film of $Cr_2O_3$ which hydrated to hydrated chromium oxyhydroxide.

Fingerprint Identification Based on Hierarchical Triangulation

( Meryam Elmouhtadi ),( Sanaa El Fkihi ),( Driss Aboutajdine ) 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.2

Fingerprint-based biometric identification is one of the most interesting automatic systems for identifying individuals. Owing to the poor sensing environment and poor quality of skin, biometrics remains a challenging problem. The main contribution of this paper is to propose a new approach to recognizing a person’s fingerprint using the fingerprint’s local characteristics. The proposed approach introduces the barycenter notion applied to triangles formed by the Delaunay triangulation once the extraction of minutiae is achieved. This ensures the exact location of similar triangles generated by the Delaunay triangulation in the recognition process. The results of an experiment conducted on a challenging public database (i.e., FVC2004) show significant improvement with regard to fingerprint identification compared to simple Delaunay triangulation, and the obtained results are very encouraging.

Predicting Brain Tumor Using Transfer Learning

Mustafa Abdul Salam,Sanaa Taha,Sameh Alahmady,Alwan Mohamed International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.5

Brain tumors can also be an abnormal collection or accumulation of cells in the brain that can be life-threatening due to their ability to invade and metastasize to nearby tissues. Accurate diagnosis is critical to the success of treatment planning, and resonant imaging is the primary diagnostic imaging method used to diagnose brain tumors and their extent. Deep learning methods for computer vision applications have shown significant improvements in recent years, primarily due to the undeniable fact that there is a large amount of data on the market to teach models. Therefore, improvements within the model architecture perform better approximations in the monitored configuration. Tumor classification using these deep learning techniques has made great strides by providing reliable, annotated open data sets. Reduce computational effort and learn specific spatial and temporal relationships. This white paper describes transfer models such as the MobileNet model, VGG19 model, InceptionResNetV2 model, Inception model, and DenseNet201 model. The model uses three different optimizers, Adam, SGD, and RMSprop. Finally, the pre-trained MobileNet with RMSprop optimizer is the best model in this paper, with 0.995 accuracies, 0.99 sensitivity, and 1.00 specificity, while at the same time having the lowest computational cost.