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좌제기제가 Propranolol의 생체이용율에 미친영향
조삼상,이진환 조선대학교 약학연구소 1994 藥學硏究誌 Vol.16 No.1
This paper was designed to investigate the influence of suppository bases contained dextran 40000 on the rectal absorption and the dissolution rate of propranolol witepsol suppository. Suppositories were prepared by the fusion method. Propranolol(16㎎) was added to the witepsol base which containing 2.5, 5, 10% of dextran. The release rate of propranolol from witepsol suppository were decreased with increasing dextran content. The maximum blood concentration (C_max) were decreased and time to reach C_max(T_max) were delayed with increasing dextran content and the relative bioavailabilities were increased. After all, Dextran could be applied in sustained release suppository of propranolol.
The State Estimator for Underwater Vehicle Systems
Kim, Hwan-Seong,You, Sam0Sang,Lee, Jin-Woo 한국해양대학교 산업기술연구소 2003 연구논문집 Vol.20 No.-
In this paper, an estimation method for extimating teh states of underwater vehicle systems with external unknown disturbance is proposed. First, the dynamics of underwater vehicle are induced by Taylor series expansion in the vertical plane and horizontal plane, respectively. For constructing the vehicle model, the external efforts, i.e., the sea surface disturbances, the current, wave and etc., are regarded as external unknown disturbances. Thus the disturbances is added as external input into state-space form of underwater vehicle systems. To estimate the state of systems with unknown disturbance, a disturbance observer which does not effected the external unknown input is proposed, and the existence condition for the observer is given. Finally, the effectiveness of the proposed disturbance observer for underwater vehicle systems is verified by using numerical simulation.