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Odontoblast TRP Channels and Thermo/Mechanical Transmission
Son, A.R.,Yang, Y.M.,Hong, J.H.,Lee, S.I.,Shibukawa, Y.,Shin, D.M. SAGE Publications 2009 Journal of dental research Vol.88 No.11
<P>Odontoblasts function as mechanosensory receptors because of the expression of mechanosensitive channels in these cells. However, it is unclear if odontoblasts direct the signal transmission evoked by heat/cold or osmotic changes. This study investigated the effects of heat/cold or osmotic changes on calcium signaling and the functional expression of the thermo/mechanosensitive transient receptor potential (TRP) channels in primary cultured mouse odontoblastic cells, with the use of RT-PCR, fluorometric calcium imaging, and electrophysiology. TRPV1, TRPV2, TRPV3, TRPV4, and TRPM3 mRNA was expressed, but TRPM8 and TRPA1 mRNA was not. The receptor-specific stimulation of TRPV1-3 (heat-sensing receptors) and TRPV4/ TRPM3 (mechanic receptors) caused increases in the intracellular calcium concentration. Moreover, the channel activities of TRPV1-4 and TRPM3 were confirmed by a whole-cell patch-clamp technique. These results suggest that primary cultured mouse odontoblasts express heat/mechanosensitive TRP channels and play a role in the underlying mechanisms of thermo/mechanosensitive sensory transmission.</P>
Effects of Dietary Cellulose on the Basal Endogenous Loss of Phosphorus in Growing Pigs
Son, A.R.,Kim, B.G. Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.3
An experiment was conducted to determine the effect of cellulose concentration in diets containing no phosphorus (P) on the basal endogenous loss (BEL) of P in growing pigs. Twelve barrows (an initial mean body weight = $49.6{\pm}3.2kg$) were individually housed in metabolism crates. Pigs were allotted to 4 experimental diets according to a cross-over design with 12 animals and 2 periods. Four P-free diets were mainly based on corn starch, sucrose, and gelatin, and were formulated to contain 0%, 4%, 8%, or 12% cellulose. Each period consisted of a 5-d adaptation and a 5-d collection period. The marker-to-marker method was used for fecal collection. The feed intake (p<0.05, linear and quadratic) and dry feces output (p<0.01, linear and quadratic) were increased with increasing dietary cellulose concentration. However, P concentration in the feces was decreased (p<0.01, linear and quadratic) with increasing dietary cellulose concentration. There was no significant difference in total P output and the BEL of P as mg per kg DMI (ranging from 157 to 214 mg/kg of dry matter intake) among experimental diets. However, values for the apparent total tract digestibility of energy, dry matter, organic matter, crude protein, and calcium were linearly decreased (p<0.01) with increasing cellulose concentration in the diet. In conclusion, dietary cellulose affected the amount of feces and digestibility of energy and nutrients, but did not affect the endogenous loss of P.
Alum Catalyzed Convenient Synthesis of Quino[2,3-b][1,5 benzoxazepine α-Aminophosphonate Derivatives
Sonar, Swapnil S.,Sadaphal, Sandip A.,Shitole, Nana V.,Jogdand, Nivrutti R.,Shingate, Bapurao B.,Shingare, Murlidhar S. Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.8
We have described an efficient synthesis of quino[2,3-b][1,5]benzoxazepine α-aminophosphonate derivatives by the nucleophilic addition of triethyl phosphite to substituted quino[2,3-b][1,5]benzoxazepines promoted by easily available, inexpensive and mild catalyst KAl(S$O_4)_2{\cdot}12H_2$O(alum). The reactions proceed smoothly at room temperature under solvent-free reaction conditions and providing high yield of product in very short reaction time.
Alum Catalyzed Simple and Efficient Synthesis of Bis(indolyl)methanes by Ultrasound Approach
Sonar, Swapnil S.,Sadaphal, Sandip A.,Kategaonkar, Amol H.,Pokalwar, Rajkumar U.,Shingate, Bapurao B.,Shingare, Murlidhar S. Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.4
Alum $(KAl(SO_4)_2{\cdot}12H_2O)$ is an inexpensive, efficient, non‐toxic and mild catalyst for the synthesis of bis(indolyl)methanes by the reaction of 1H-indole with various aldehydes/ketones under the influence of ultrasound irradiation in solvent‐free condition. The remarkable advantages of this method are the simple experimental procedures, shorter reaction times, high yields of product and green aspects by avoiding toxic catalysts and solvents.
Alum Catalyzed Simple and Efficient Synthesis of Bis(indolyl)methanes by Ultrasound Approach
Swapnil S. Sonar,Sandip A. Sadaphal,Amol H. Kategaonkar,Rajkumar U. Pokalwar,Bapurao B. Shingate,Murlidhar S. Shingare 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.4
Alum (KAl(SO4)2․12H2O) is an inexpensive, efficient, non‐toxic and mild catalyst for the synthesis of bis(indolyl)methanes by the reaction of 1H-indole with various aldehydes/ketones under the influence of ultrasound irradiation in solvent‐free condition. The remarkable advantages of this method are the simple experimental procedures, shorter reaction times, high yields of product and green aspects by avoiding toxic catalysts and solvents.
Alum Catalyzed Convenient Synthesis of Quino[2,3-b][1,5]benzoxazepine α-Aminophosphonate Derivatives
Swapnil S. Sonar,Sandip A. Sadaphal,Nana V. Shitole,Nivrutti R. Jogdand,Bapurao B. Shingate,Murlidhar S. Shingare 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.8
We have described an efficient synthesis of quino[2,3-b][1,5]benzoxazepine α-aminophosphonate derivatives by the nucleophilic addition of triethyl phosphite to substituted quino[2,3-b][1,5]benzoxazepines promoted by easily available, inexpensive and mild catalyst KAl(SO4)2・12H2O (alum). The reactions proceed smoothly at room temperature under solvent-free reaction conditions and providing high yield of product in very short reaction time.
Novel SVPWM technique for three-level T-type Z-source inverters
Singh, Satwant,Sonar, Santosh The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.2
In this paper, a new SVPWM switching technique, named ZSVM_1TI, has been proposed for a three-level (3L) T-type Z-source inverter (ZSI). ZSVM_1TI is based on three main modifications of the existing PWM techniques for 3L inverters. First, the existing SVPWM of a 3L ZSI has been modified to double the frequency of the null interval. After that, an improved version of the maximum boost control (MBC) has been proposed based on modified SVPWM to eliminate the problem of the sixth frequency ripple components of inductor current with the existing MBC technique of ZSIs. Finally, a new switching pattern of a reduced common-mode voltage (CMV) PWM technique has been proposed to increase the switching frequency of the impedance network so that the size of the passive elements can be reduced. The proposed ZSVM_1TI has been compared with the existing PWM technique in terms of the size of the impedance network, the dc-link utilization, and the inductor current ripple profile. The above-mentioned findings have been successfully validated using theoretical analysis, simulations, and experimental results.
Sadaphal, Sandip A.,Sonar, Swapnil S.,Pokalwar, Rajkumar U.,Shitole, Nanasaheb V.,Shingare, Murlidhar S. Korean Chemical Society 2009 대한화학회지 Vol.53 No.5
무용제하에서 $\alpha$-히드록시 인산염을 합성하기 위해 술팜산은 비용효율이 높고 일반적인 산들의 친환경적인 대안으로 활용되었다. 초음파 조사를 이용하여 더 나은 수율을 얻었고 반응시간이 짧았다. Sulphamic acid has been exploited as a cost-effective catalyst and green alternative for conventional acidic materials to synthesize $\alpha$-hydroxy phosphonates under solvent-free condition. The reaction carried out using ultrasound irradiation with better yields and shorter reaction time.
Sadaphal, Sandip A.,Sonar, Swapnil S.,Kategaonkar, Amol H.,Shingare, Murlidhar S. Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.5
We have demonstrated a one-pot three component coupling of an aldehydes, an amines, and triethyl phosphite using 1-benzyl-3-methyl imidazolium hydrogen sulphate [bnmim][][$HSO_{4}$] as an efficient catalyst. All the reactions proceed under solvent-free conditions at room temperature. This methodology afforded the corresponding $\alpha$-aminophosphonates in shorter reaction times with excellent yields.