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von Thomas Oppermann 中央大學校 法科大學 1987 法政論叢 Vol.27 No.-
Es ist mir eine besondere Freude, daß diese Arbeit in Korea erscheinen kann. Im August 1986 hielt ich mich anlaßlich der 62. Konferenz der International Law Association (ILA) in Korea auf. Hierbei wurde die "Seoul-Erklarung" der ILA zu Prinzipien der Weltwirtschaftsordnung verabschiedet, die Gegenstand dieser Arbeit ist. Ich benutzte diesen Aufenthalt in Seoul und Pusan zugleich, um meine koreanischen Kollegen und Freunde aus der deutsch-koreanischen Juristengesellschaft zu besuchen. Ich erwahne unter vielen besonders Professor Dr. Youngsol KWON von der Chung-Ang-Universitat Seoul und Professor Dr. Kyung HUH von der Yonsei-Universitat Seoul, die beide langere Zeit bei mir an der Juristischen Fakultat der Eberhards-Karls-Universitat Tubingen geforscht haben. Ich erinnere mich sehr gerne an die Tage in Seoul und auch in Pusan bei Professor Dr. Hyo-Jeon KIM, Dong-A-Universitat, wo ich dank freundlicher Einladungen Vortrage halten konnte. Ich widme diese Arbeit in dankbarer Erinnerung allen koreanischen Kollegen, die ich kennenlernen durfte.
( Sybille D Reichardt ),( Martin Oppermann ),( Holger M Reichardt ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Glucocorticoids (GCs) are widely used in the clinic to treat autoimmune and atopic diseases but they also cause many side-effects. Here we characterized a yet unknown activity of GCs in the stomach, namely the induction of gastroparesis by oral application of dexamethasone. Using conditional knock-out mice we initially ruled out that enterocytes or macrophages were responsible for the observed effect. This finding suggested that the stomach itself was the primary target of GC action. Against our expectations, however, impaired gastric emptying was also unrelated to the enhanced HCl production after dexamethasone administration. In contrast, we found that oral GC therapy up-regulated arginase 2 in the stomach. Importantly, this effect should lead to the depletion of L-arginine and thereby impede production of nitric oxide, which is required for gastric motility. In support of this notion, supplementing the drinking water with L arginine prevented the induction of gastroparesis by dexamethasone in mice. Our fi ndings suggest that combining L-arginine with orally applied GCs might reduce treatment-related gastrointestinal complications. Furthermore, our data provide a plausible explanation for the well-known anti-emetic effect of GCs. In the future it will be intriguing to explore whether the observed phenomenon can be confi rmed in patients under high-dose GC therapy as well.
CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study
Igor Tsaur,Anika Noack,Jasmina Makarevic,Elsie Oppermann,Ana Maria Waaga-Gasser,Martin Gasser,Hendrik Borgmann,Tanja Huesch,Kilian M. Gust,Michael Reiter,David Schilling,Georg Bartsch,Axel Haferkamp,R 대한암학회 2015 Cancer Research and Treatment Vol.47 No.2
Purpose Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making theidentification of novel, precise diagnostic biomarkers important. Since chemokines areassociated with more aggressive disease and poor prognosis in diverse malignancies, weaimed to investigate the diagnostic relevance of chemokines in PCa. Materials and MethodsPreoperative and early postoperative serum samples were obtained from 39 consecutivePCa patients undergoing radical prostatectomy. Serum from 15 healthy volunteers servedas controls. Concentrations of CXCL12, CXCL13, CX3CL1, CCL2, CCL5, and CCL20 weremeasured in serum by Luminex. The expression activity of CXCR3, CXCR4, CXCR5, CXCR7,CXCL12, CXCL13, CX3CR1, CXCL1, CCR2, CCR5, CCR6, CCR7, CCL2, and CCL5 mRNA wasassessed in tumor and adjacent normal tissue of prostatectomy specimens by quantitativereal-time polymerase chain reaction. The associations of these chemokines with clinicaland histological parameters were tested. ResultsThe gene expression activity of CCL2 and CCR6 was significantly higher in tumor tissuecompared to adjacent normal tissue. CCL2 was also significantly higher in the blood samplesof PCa patients, compared to controls. CCL5, CCL20, and CX3CL1 were lower in patientserum, compared to controls. CCR2 tissue mRNA was negatively correlated with the Gleasonscore and grading. ConclusionChemokines are significantly modified during tumorigenesis of PCa, and CCL2 is a promisingdiagnostic biomarker.
Adsorption studies on nano-zirconia in water and a water-1,2-propanediol mixture
C. Renger,P. Kuschel,A. Kristoffersson,B. Clauss,W. Oppermann,W. Sigmund 한양대학교 세라믹연구소 2006 Journal of Ceramic Processing Research Vol.7 No.2
The adsorption of an electrosteric (polyacrylic acid, PAA), an electrostatic (triammonium citrate, TAC) and a steric dispersant (2-(2-(2 methoxy ethoxy) ethoxy)acetic acid, TODA) onto nanozirconia particles in deionized (d.i.) water and in a 75 wt% water-25 wt% 1,2-propanediol mixture was investigated. The amount of dispersant in d.i. water yielding the lowest apparent viscosity was measured via rheology. For PAA this was determined to be 6 wt%, for TAC 2 wt% (which corresponds to ≈ 0.43 mg/m2) and for TODA also 2 wt% (corresponding to ≈ 0.34 mg/m2). In the water-propanediol mixture the minimum viscosity was measured and the adsorbed amount was determined by adsorption isotherms using the depletion method. For TAC this was ≈ 0.076 mg/m2, which is five times less than the value in pure water. Furthermore, zeta-potential measurements were performed to confirm the dispersion mechanism. Zirconia particles in water showed the same zeta-potential as in waterpropanediol, although in water-propanediol less TAC molecules were adsorbed on the surface. For TODA the adsorbed amount was calculated to be ≈ 0.4 mg/m2, which fits well to the value determined in water. Propanediol seems not to influence the adsorption in that case.