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      • KCI등재

        Extracorporeal photopheresis for chronic graft-versus-host disease: a systematic review and meta-analysis

        Mohsin Ilyas Malik,Mark Litzow,William Hogan,Mrinal Patnaik,Mohammad Hassan Murad,Larry J. Prokop,Jeffrey L. Winters,Shahrukh Hashmi 대한혈액학회 2014 Blood Research Vol.49 No.2

        Background The safety of extracorporeal photopheresis (ECP) in steroid-refractory chronic graft-versus- host disease (SR-cGVHD) has been explored in multiple studies but reported response rates (RR) vary significantly across studies. Methods We conducted a meta-analysis to assess the efficacy of ECP for SR-cGVHD. A search of electronic databases for studies published between 1984 and 2012 was conducted. End points included RR: complete response (CR), overall response rates (ORR), and organ- specific RR. The initial search generated 312 studies, of which 18 met the selection criteria (N=595). A random effects model was used for pooled rates. Results Pooled CR rates and ORR were 29% (confidence interval [CI], 19‒42%) and 64% (CI, 65‒ 82%), respectively. One-year overall survival was available for 4 studies only and was 49% (CI, 29‒70%). The pooled RR for skin, liver, ocular, oral, lung, gastrointestinal and musculoskeletal SR-cGVHD was 74%, 68%, 60%, 72%, 48%, 53%, and 64%, respectively. There was a significant heterogeneity among studies due to differences in ECP schedules and duration. No significant differences in responses to ECP for pediatric and adult populations were found. Sensitivity analysis could not be undertaken due to a limited number of prospective studies. Conclusion ECP is an effective therapy for oral, skin, and liver SR-cGVHD, with modest activity in lung and gastrointestinal SR-cGVHD.

      • KCI등재

        Measurement of Traffic-Related Air Pollution in Peshawar, Pakistan - A Pilot Study

        Mohsin Khan,Mohammad Abdul Aziz Irfan,Najeeb Ullah 한국대기환경학회 2021 Asian Journal of Atmospheric Environment (AJAE) Vol.15 No.4

        This pilot study measured Traffic-Related Air Pollution (TRAP) and calculated the corresponding Air Quality Index (AQI) in Peshawar. Using Libelium wireless sensors, the research measured outdoor TRAP and monitored indoor air quality for 48 days. The maximum outdoors daily mean concentration was 47 μg m-3 for PM1, 90 μg m-3 for PM2.5, 356 μg m-3 for PM10, 258 ppb for SO2, and 219 ppb for NO2, respectively. This corresponds to PM2.5 AQI of 158 (Unhealthy), PM10 AQI of 148 (Unhealthy for Sensitive Groups; USG), SO2 AQI of 181 (Unhealthy), and NO2 AQI of 123 (USG). The maximum daily average concentration for the indoor condition was 31 μg m-3 for PM1, 49 μg m-3 for PM2.5, 78 μg m-3 for PM10, 465 ppb for SO2, and 247 ppb for NO2, respectively. The corresponding AQI was 135 (USG) for PM2.5, 62 (Moderate) for PM10, 254 (Very Unhealthy) for SO2, and 129 (USG) for NO2. Data analysis shows that about 73% of the overall indoor AQI falls in the category of “USG”, while SO2 was the largest contributor to overall AQI. The study concludes that indoor AQI was slightly better than outdoor AQI because of the distance and height from the outdoor location. Moreover, Pakistan’s AQI for PM2.5 exceeds WHO’s 24-hours limit; however, it was relatively better by 23%, 65%, and 170% compared to China, India, and Bangladesh, respectively. In contrast, AQI for SO2 and NO2 was poor as compared to the same countries. The concentration and AQI for traffic-related air pollutants remain unhealthy and sometimes becomes hazardous, which means the sensitive groups are at greater risk.

      • KCI등재

        Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial

        Mohsin Qadeer,Muhammad Waqas,Muhammad Jawad Rashid,Syed Ather Enam,Salman Sharif,Ghulam Murtaza 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.1

        Study Design: Randomized controlled trial. Purpose: The purpose of this study was to compare pregabalin and gabapentin for mean postoperative visual analog score (VAS) for pain in patients undergoing single-level lumbar microdiscectomy for intervertebral disc prolapse at a tertiary care hospital. Overview of Literature: Pregabalin has a superior pharmacokinetic profile and analgesic effect at lower doses than gabapentin; however, analgesic efficacy must be established during the perioperative period after lumbar spine surgery. Methods: This randomized controlled trial was carried out at our institute from February to October 2011 on 78 patients, with 39 participants in each study group. Patients undergoing lumbar microdiscectomy were randomized to group A (gabapentin) or group B (pregabalin) and started on trial medicines one week before surgery. The VAS for pain was recorded at 24 hours and one week postoperatively. Results: Both groups had similar baseline variables, with mean ages of 42 and 39 years in groups A and B, respectively, and a majority of male patients in each group. The mean VAS values for pain at 24 hours for gabapentin vs. pregabalin were comparable (1.97±0.84 vs. 1.6±0.87, respectively; p =0.087) as were the results at one week after surgery (0.27±0.45 vs. 0.3±0.46, respectively; p =0.79). None of the patients required additional analgesia postoperatively. After adjusting for age and sex, the VAS value for group B patients was 0.028 points lower than for group A patients, but this difference was not statistically significant (p =0.817, R2=0.018). Conclusions: Pregabalin is equivalent to gabapentin for the relief of postoperative pain at a lower dose in patients undergoing lumbar microdiscectomy. Therefore, other factors, such as dose, frequency, cost, pharmacokinetics, and side effects of these medicines, should be taken into account whenever it is prescribed.

      • A new generally weighted moving average control chart based on Taguchi’s loss function to monitor process mean and dispersion

        Mohsin, Muhammad,Aslam, Muhammad,Jun, Chi-Hyuck SAGE Publications 2016 PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGIN Vol.230 No.8

        <P>Several control charts have been constructed to simultaneously monitor the process mean and variability. A single chart is often used instead of two charts to detect shift in the process mean and variability separately. A new single generally weighted moving average control chart is now proposed to monitor the process mean and dispersion simultaneously, based on Taguchi's loss function. A Monte Carlo simulation is used to calculate average run length to study the performance of this control chart when the process is shifted. A comparison is made with an exponentially weighted moving average control chart in terms of average run lengths. Two examples are also included for showing the practical application of the proposed control chart.</P>

      • Qatari Company Liability Actions in the Shadow of Controlling Shareholders: A Comparative Analysis of Qatar and the UK

        ( Mohsin Hamad Al-marri ) 고려대학교 법학연구원 2023 The Asian Business Lawyer Vol.30 No.-

        The problem of this research is correlate to the doing business report of 2020 in which minority shareholders’ rights in Qatar were assessed to be in a deteriorated position. The driving force of this deterioration is related to the power that controlling shareholders exert in curbing any development of an efficient minority shareholder remedy system. Controlling shareholders are prevalent in publicly held companies on the Qatar Stock Exchange. Their presence shifts the agency problem from one of agent-principal agency to one of principal-principal agency. This article highlights the inefficiency of the substantive and procedural rules for the company liability actions available to shareholders. It argues that company liability actions have been designed to foster controlling shareholders’ immunity against future claims. This is dysfunctional for minority shareholders rights for the mechanics of the claim to have been designed for the sole use of controlling shareholders. This study adopts the comparison methodology between Qatar and the UK legal system. The comparison of two legal system strives to articulates the resemblance of the Qatari claim to the rule in Foss v Harbottle, where the proper claimants are not the shareholders but the company. As a result, the minority are at the mercy of the controlling shareholders who have the cash flow and voting rights to steer general meeting outcomes. The findings of this study revels that article 115 of Qatar Companies Law need urgent major amendments. The article suggests the repeal of article 15 of Qatari companies law and the transplantation of prima facie threshold in the UK legal system to Qatar’s civil system.

      • SCOPUS

        Social Support in the Times of Social Distancing: Learnings from the South Asian Context

        Mohsin BASHIR,Ammara SALEEM,Qamar ALI 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.3

        This study will examine the relationship between social support from the work and family domains, referred to as multiple social network ties (MSNT), and employees’ job and family-related performance outcomes during the COVID-19 crisis. The study also demonstrates the importance of employees’ work-family balance (WFB) in moderating the association between MSNT and job and family-related performance. A two-wave design was used to collect data from 320 managerial level personnel in Pakistan’s textile sector. The path analysis technique of structural equation modelling (SEM) was used to analyze the responses. In times of crisis, social support mechanisms could potentially replace organizational support mechanisms for employees dealing with work and family obligations, according to the study. The findings of this study show that work-family balance is a significant partial mediator between MSNT and employees’ job and familyrelated outcomes during the COVID-19 pandemic, according to a best-fit model. This research supports the pragmatic view of MSNT’s action mechanism in generating jobs for employees and family-related results, especially in uncertain situations. According to the findings, employees who have a positive work-life balance are happier and more productive in both work and personal life. It has major implications for human resource management (HRM) research and practice.

      • KCI등재

        Effects of 3.5 MeV Proton Irradiation on Pure Zirconium

        Mohsin Rafique,San Chae,Qurat ul ain Sahi,Yong-Soo Kim 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.3

        The effects of high energy proton irradiation on pure zirconium were investigated in this study. The annealed Zr specimens (50 mm × 3 mm × 0.8 mm) were irradiated by 3.5 MeV hydrogen ions with dose ranges from 1×10 13 to 1 × 10 15 ions/cm 2 at 335 K. The range of the proton beam penetration was measured to be 68-70 μm, depending on the surface, which is in good agreement with the SRIM simulation results. X-ray diffractometer analysis revealed that the peak intensity of the basal plane increased and the position of the peak shifted due to the proton irradiation. Field emission scanning electron microscopy results showed that with increasing irradiation dose hydrogen micro-bubbles formed, concentrated, interconnected, and eventually burst due to the excessive hydrogen pressure inside, causing surface-crack development. Measured yield and ultimate tensile strength seemed to be insignificantly affected by the proton irradiation.

      • Distributed Incremental Approximate Frequent Itemset Mining Using MapReduce

        Mohsin Shaikh,Irfan Ali Tunio,Syed Muhammad Shehram Shah,Fareesa Khan Sohu,Abdul Aziz,Ahmad Ali International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.5

        Traditional methods for datamining typically assume that the data is small, centralized, memory resident and static. But this assumption is no longer acceptable, because datasets are growing very fast hence becoming huge from time to time. There is fast growing need to manage data with efficient mining algorithms. In such a scenario it is inevitable to carry out data mining in a distributed environment and Frequent Itemset Mining (FIM) is no exception. Thus, the need of an efficient incremental mining algorithm arises. We propose the Distributed Incremental Approximate Frequent Itemset Mining (DIAFIM) which is an incremental FIM algorithm and works on the distributed parallel MapReduce environment. The key contribution of this research is devising an incremental mining algorithm that works on the distributed parallel MapReduce environment.

      • KCI등재

        Effect of ethyl acetate aroma on viability of human breast cancer and normal kidney epithelial cells in vitro

        Mohsin A. Khan,Rumana Ahmad,Anand N. Srivastava 한국한의학연구원 2017 Integrative Medicine Research Vol.6 No.1

        Background: Aromatherapy is used in clinical settings for patients suffering from several chronic and critical diseases such as cancer. Ethyl acetate (EA) is a colorless liquid with a characteristic fruity smell and is naturally present in fruits and wines. Methods: In the present study, the effect of the aroma of EA was evaluated on human breast cancer cell line MDA-MB-231 and normal cell line, Vero. Cell line viability and mechanism of EA cytotoxicity were determined by Trypan blue dye exclusion assay and phase contrast microscopy. Results: It was found that EA at a concentration of 0.026 M was effective in causing considerable cytotoxicity in breast cancer cells (without even coming in contact with the culture medium and cells), while showing no effect on normal cells. Mechanism of action of EA on cancer and Vero cells was investigated by DNA fragmentation and dye binding assays using agarose gel electrophoresis (AGE) and fluorescence microscopy/cytometry, respectively. It was found that EA aroma induced predominantly necrosis in the cancer cells exposed to it. Conclusion: A study such as this has not been attempted before and results need further investigation before EA aroma can be used as a complementary therapy.

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