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A Simple Nanocomposite Coating Process for Titanium Metal Surfaces Using a Polyborazine Precursor
Hong, Lan-Young,Kim, Dong-Jin,Kim, Dong-Pyo 한국공업화학회 2004 Journal of Industrial and Engineering Chemistry Vol.10 No.6
A Ti-based nanocomposite coating layer was produced by simple dip-coating of low-viscosity polyborazine, -[B₃N₃H,]_x-, onto a bare Ti substrate surface, followed by pyrolysis at up to 1400℃ under an inert atmosphere. When annealed at higher temperatures, the Ti surface layer showed a step-wise change to form a nanocomposite phase composed of TiO₂, TiN, and TiNyOz, starting from the formation of TiO₂at 800℃ as a result of the presence of native oxygen. The hardness of the modified surface increased to 304 Hv from 132 Hv for the bare sample. The formation mechanism was studied using XRD, SEM, AES, and ESCA instruments. These preliminary results prove that the efficient nanocomposite coating process using preceramic polymers is a promising route for producing designed compositions on metal bodies for various industrial applications.
Lan, Han-hong,Wang, Cui-mei,Chen, Shuang-shuang,Zheng, Jian-ying The Korean Society of Plant Pathology 2019 Plant Pathology Journal Vol.35 No.5
Interplay between Cymbidium mosaic virus (CymMV)/Odontoglossum ringspot virus (ORSV) and its host plant Phalaenopsis equestris remain largely unknown, which led to deficiency of effective measures to control disease of P. equestris caused by infecting viruses. In this study, for the first time, we characterized viral small interfering RNAs (vsiRNAs) profiles in P. equestris co-infected with CymMV and ORSV through small RNA sequencing technology. CymMV and ORSV small interfering RNAs (siRNAs) demonstrated several general and specific/new characteristics. vsiRNAs, with A/U bias at the first nucleotide, were predominantly 21-nt long and they were derived predominantly (90%) from viral positive-strand RNA. 21-nt siRNA duplexes with 0-nt overhangs were the most abundant 21-nt duplexes, followed by 2-nt overhangs and then 1-nt overhangs 21-nt duplexes in infected P. equestris. Continuous but heterogeneous distribution and secondary structures prediction implied that vsiRNAs originate predominantly by direct Dicer-like enzymes cleavage of imperfect duplexes in the most folded regions of the positive strand of both viruses RNA molecular. Furthermore, we totally predicted 54 target genes by vsiRNAs with psRNATarget server, including disease/stress response-related genes, RNA interference core components, cytoskeleton-related genes, photosynthesis or energy supply related genes. Gene Ontology classification showed that a majority of the predicted targets were related to cellular components and cellular processes and performed a certain function. All target genes were down-regulated with different degree by vsiRNAs as shown by real-time reverse transcription polymerase chain reaction. Taken together, CymMV and ORSV siRNAs played important roles in interplay with P. equestris by down modulating the expression levels of endogenous genes in host plant.
Effect of Component Ratios on the Performance of UV Curing Organic/Inorganic Coating
Hong, Lan-Young,Cho, Young-Seok,Kim, Dong-Pyo 한국공업화학회 2005 Journal of Industrial and Engineering Chemistry Vol.11 No.2
A transparent, hard organic/inorganic hybrid coating system was prepared using various mixing ratios of its components; the sequential process involved UV curing of commercially organic resins followed by thermal condensation of the inorganic component at 120℃ for 12 h. The hybrid precursors were spin-coated on polycarbonate substrates to form 4~13 μm thick films, with no cracks. The inorganic component was prepared through sol-gel reactions by mixing 5:1, 1:2, 2:1, and 1:5 mole ratios of tetraethoxysilane (TEOS) and methacryloxypropyltrimethoxysilane (MPTMS); the organic component was prepared by adding of 4:3:3 wt% ratio of UV-curable urethane acrylate oligomer, multifunctional trimethylolpropanetriacrylate (TMPTA), and hexanedioldiacrylate (HDDA). In general, as the inorganic SiO₂con-tent and the mixing ratio of coupling agent MPTMS increased, higher miscibility of hybrids occurred without phase separation, which gave greatly improved abrasion resistance when compared to organic component-dominated specimens. The morphology and phase homogeneity of the coating systems on the nanometer scale were investigated by chemical and microscopic characterization.
Transcriptome Analysis of Long-Term Exposure to Blue Light in Retinal Pigment Epithelial Cells
( Hong Lan Jin ),( Kwang Won Jeong ) 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.3
Dry age-related macular degeneration (AMD) is a type of progressive blindness that is primarily due to dysfunction and the loss of retinal pigment epithelium (RPE). The accumulation of N-retinylidene-N-retinylethanolamine (A2E), a by-product of the visual cycle, causes RPE and photoreceptor degeneration that impairs vision. Genes associated with dry AMD have been identified using a blue light model of A2E accumulation in the retinal pigment epithelium and transcriptomic studies of retinal tissue from patients with AMD. However, dry macular degeneration progresses slowly, and current approaches cannot reveal changes in gene transcription according to stages of AMD progression. Thus, they are limited in terms of identifying genes responsible for pathogenesis. Here, we created a model of long-term exposure to identify temporally-dependent changes in gene expression induced in human retinal pigment epithelial cells (ARPE-19) exposed to blue light and a non-cytotoxic dose of A2E for 120 days. We identified stage-specific genes at 40, 100, and 120 days, respectively. The expression of genes corresponding to epithelial-mesenchymal transition (EMT) during the early stage, glycolysis and angiogenesis during the middle stage, and apoptosis and inflammation pathways during the late stage was significantly altered by A2E and blue light. Changes in the expression of genes at the late stages of the EMT were similar to those found in human eyes with late-stage AMD. Our results provide further insight into the pathogenesis of dry AMD induced by blue light and a novel model in vitro with which relevant genes can be identified in the future.
Hong, Lan-Young,Ryu, So-Hyoung,Kim, Dong-Pyo American Scientific Publishers 2010 Journal of nanoscience and nanotechnology Vol.10 No.10
<P>The microcellular SiCN ceramics with high porosity and high surface area were fabricated from polysilazane as a viscous SiCN ceramic precursor and expandable microspheres as a self-sacrificial template. The fabrication steps were composed of (1) forming of expandable microsphere compact, (2) infiltrating polysilazane into the compact, (3) foaming and curing, (4) pyrolysis in N2 gas. The microcellular structures and properties of the obtained ceramic products depended on the foaming and curing conditions as well as the pyrolysis temperature. When foamed and cured at 120 degrees C for 30 min, then pyrolyzed at 1000 degrees C in N2, the microcellular product exhibited the largest cell size 9.3 microm with the lowest cell densities 2.2 x 108 cells/cm2, 93% of porosity and surface area of 356 m2/g. Furthermore, the higher temperature pyrolysis at 1300 degrees C induced significant change in the microcellular morphology by reducing the cell size with thicker wall and the cell density. Finally, it demonstrated an efficient way of manufacturing highly porous microcellular ceramics with no etching process using a polyvinylsilazane and expandable microspheres for catalytic supporting application.</P>
Lan Hong,Guo-Hua Gong,Li Yu,Ming-Xia Song,Xun Cui,Zhe-Shan Quan 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.11
A series of 7-alkoxy-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones was synthesized and theirnegative inotropic effects were evaluated by measuring theleft atrium stroke volume in isolated rabbit heart preparations. All compounds moderated the cardiac workload bydecreasing heart rate and contractility (inotropic effects). Among them, compound 6 was found to be best potent witha -28.89 ± 1.91 % decrease in the stroke volume at aconcentration of 3 9 10-5 M in our in vitro study.