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Neurological Adverse Reactions to SARS-CoV-2 Vaccines
Josef Finsterer(Josef Finsterer ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
SARS-CoV-2 vaccines are not free of side effects and most commonly affect the central or peripheral nervous system (CNS, PNS). This narrative review aims to summarise recent advances in the nature, frequency, management, and outcome of neurological side effects from SARS-CoV-2 vaccines. CNS disorders triggered by SARS-CoV-2 vaccines include headache, cerebro-vascular disorders (venous sinus thrombosis [VST], ischemic stroke, intracerebral hemorrhage, subarachnoid bleeding, reversible, cerebral vasoconstriction syndrome, vasculitis, pituitary apoplexy, Susac syndrome), inflammatory diseases (encephalitis, meningitis, demyelinating disorders, transverse myelitis), epilepsy, and a number of other rarely reported CNS conditions. PNS disorders related to SARS-CoV-2 vaccines include neuropathy of cranial nerves, mono-/polyradiculitis (Guillain–Barre syndrome [GBS]), Parsonage–Turner syndrome (plexitis), small fiber neuropathy, myasthenia, myositis/dermatomyositis, rhabdomyolysis, and a number of other conditions. The most common neurological side effects are facial palsy, intracerebral hemorrhage, VST, and GBS. The underlying pathophysiology is poorly understood, but several speculations have been generated to explain the development of CNS/PNS disease after SARS-CoV-2 vaccination. In conclusion, neurological side effects develop with any type of SARS-CoV-2 vaccine and are diverse, can be serious and even fatal, and should be taken seriously to initiate early treatment and improve outcome and avoid fatalities.
Catheter Ablation of Multiple Accessory Pathways in Duchenne Muscular Dystrophy
Josef Finsterer,Claudia Stöllberger,Christine Steger,Edmund Gatterer 대한심장학회 2013 Korean Circulation Journal Vol.43 No.2
A 23-year-old male with Duchenne muscular dystrophy (DMD) experienced self-limiting palpitations at age 19 years for the first time. Palpitations recurred not earlier than at age 23 years, and were attributed to narrow complex tachycardia, which could be terminated with adenosine. Since electrocardiography showed a delta-wave, Wolff-Parkinson-White (WPW) syndrome was diagnosed, ajmaline prescribed and radio-frequency catheter ablation of three accessory pathways carried out one week later. One day after ablation, however, a relapse of the supraventricular tachycardia occurred and was terminated with ajmaline. Re-entry tachycardia occurred a second time six days after ablation, and as before, it was stopped only with ajmaline. Despite administration of verapamil to prevent tachycardia, it occurred a third time four months after ablation. This case shows that cardiac involvement in DMD may manifest also as WPW-syndrome. In these pa-tients, repeated radio-frequency catheter ablation of accessory pathways may be necessary to completely block the re-entry mechanism.
Two New Lichen Species, Thelopsis ullungdoensis and Phylloblastia gyeongsangbukensis from Korea
( Josef P. Halda ),( Soon-ok Oh ),( Dong Liu ),( Beeyoung Gun Lee ),( Sergey Y. Kondratyuk ),( László Lőkös ),( Jung-shin Park ),( Jung-jae Woo ),( Jae-seoun Hur ) 한국균학회 2020 Mycobiology Vol.48 No.6
Two new species, Thelopsis ullungdoensis and Phylloblastia gyeongsangbukensis are described from Ullung-Do (Island), South Korea. The closest relatives from Europe and Korea are epiphytic Thelopsis flaveola which differs by their immersed or semi-immersed yellow ascomata, ascospores without halo and their habitat of smooth bark (mainly Fagus) in humid and cold climates. Thelopsis gangwondoensis differs by its bigger semi-immersed ascomata (600-700 mm in diam.), oblong halonate ascospores (8-12×6-8 mm) and its habitat of smooth bark of deciduous trees. P. gyeongsangbukensis differs from its relatives within the genus in having 5-septate ascospores (22-266-8 mm), semi-immersed, subglobose ascomata with a flattened top (250-400 mm) and a thin, matt, uneven gray-brown to gray-green continuous thallus without isidia.