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당뇨병 치료를 위한 SGLT2 억제제의 심혈관계 안전성 관련 최근 임상시험 결과고찰
김혜럼, 한나영, 유미선, 권광일, 윤휘열 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-
Patients with type 2 diabetes have a two-to three-times greater risk of developing car-diovascular disease than people without diabetes, and the mortality rate from cardiovascular disease is also reported to increase. The reason why cardiovascular disease is more common in type 2 diabetic patients is not only that cardiovascular risk factors are more common than non-diabetic patients, but also that diabetes itself is an independent risk factor for cardiovascular disease. Since rosiglitazone. which was introduced as a treatment for type 2 diabetes in 2000, has been argued to increase cardiovascular disease sluch as myocardial infarction. there were clinical trials of cardiovascular safety of it such as DREAM. ADOPT and RECORD. As a result. rosiglitazone has been banned due to the risk of cardiovascular disease. The US FDA and other regulatory agencies have required clinical trials for type 2 diabetes treatments afterward. 1n this study. it is reviewed that recently developed SGL T2 inhibitors has cardiovascular benefits as a novel mechanism of type 2 diabetes treatment. SGL T2 inhibitors inhibit the renal sodium glucose co-transporter(SGLT2), thereby reducing glucose reabsorption and increasing excretion of it. and consequently lowering blood glucose levels. Recent papers on ongoing cardiovascular-related clinical trials of SGL T2 in-hibitors such as CANVAS. CANVAS-R. CREDENCE of canagliflozin, DECLARE-TIMI 58 of dapagliflozin. and EMPA -REG outcomes of empagliflozin were examined thoroughly as well.
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Traumatic Contusion of ICR Mouse Brain by FPI : $^{1}\textrm{H}$ MR Spectroscopic Study
Park, Chi-Bong,Kim, Hwi-Yool,Jeun, Sin-Soo,Han, Young-Min,Han, Duk-Young,Kang, Young-Woon,Choe, Bo-Young Korean Society of Medical Physics 2003 의학물리 Vol.14 No.4
실험적 뇌손상 전후에 쥐의 뇌대사물질 변화를 4.7 T 자기공명분광법을 이용하여 조사하여 보았다. 자기공명 스펙트럼는 비교대상 그룹으로서 정상 쥐 우측 두전엽 피질에서 획득되었다. 유체타진손상기법(Fluid Percussion Injury)을 사용하여 뇌손상을 유발시킨후 3일 후 스펙트럼이 얻어졌다. 뇌손상 쥐의 뇌대사불질들의 변화는 정상쥐의 뇌대사물질들과 비교되었다. Neuronal marker로써 NAA/Cr 비율은 대조군에서 1.13$\pm$0.12이었고 뇌좌상부위에서 0.90$\pm$0.11로 손상전과 비교하여 대조군에 비해 유의성있는 감소소견을 나타내었으며 이는 neuronal loss를 의미하는 것으로 추정된다(P=0.001). Cho/Cr 비율은 대조군에서 0.76$\pm$0.15이었고 뇌좌상부위에서 0.91$\pm$0.17로 손상전과 비교하여 대조군에 비해 유의성있게 증가하는 경향을 나타내었으며 이는 생체막의 파괴나 염증반응과 관련된 것으로 추정된다(P=0.02). 하지만 Glx/Cr 비율은 손상전후에 유의성있는 변화를 나타내지 않았다. Lac/Cr 비율은 대조군에 비해 증가하는 경향을 나타내었고 이는 외상후 에너지 대사의 변위양상으로 고려되어진다. 이러한 소견들은 자기 공명분광법이 유체타진손상기법을 이용한 외상성 뇌좌상에서 신경병리학적 변화과정에 대한 이해를 증진시키고 나아가 외상에 의한 뇌좌상의 임상적인 평가를 위해 매우 유용한 modality임을 시사하는 것이라고 사료된다. 그러나 본 연구에서 몇몇의 케이스에서 voxel을 선정하면서 두개골의 일부가 포함되거나 혹은 죄상과 동반된 출혈로 인해 유용한 데이터를 획득하는데 어려움을 주기도 하였다. 앞으로 보다 더 세밀한 분석과 연구를 위해 유체타진 손상의 다양한 정도에서 대사물질들의 변화양상을 평가할 필요가 있을 것으로 사료된다. . In vivo $^1$H magnetic resonance spectroscopy (MRS) at 4.7 T was applied to investigate the cerebral metabolite changes of mice brain before and after experimental brain trauma. In vivo $^1$H MR spectra were acquired from a voxel covering right parietal cortex in normal brain, used as control subjects. After experimental brain trauma using the fluid percussion injury (FPI) method, $^1$H MR spectra were acquired from the same lesion three days after trauma. Metabolite ratios of the injured lesion were compared to those of controls. After trauma, N-acetylaspartate (NAA)/creatine (Cr) ratio, as a neuronal marker was decreased significantly versus controls, indicating neuronal loss. The ratio of NAA/Cr in traumatic brain contusion was 0.90$\pm$0.11, while that in normal control subjects was 1.13$\pm$0.12 (P=0.001). Choline (Cho)/Cr ratio had a tendency to rise in experimental brain contusion (P=0.02). Cho/Cr ratio after trauma was 0.91$\pm$0.17 while that before traumas was 0.76$\pm$0.15. Cho/Cr ratio was increased and this might indicate a inflammatory activity. However, no significant difference of [(glutamate+glutamine) (Glx)]/Cr was established between experimental traumatic brain injury models and normal controls. Lactate (Lac)/Cr ratio was appeared as a sign of shifted posttraumatic energy metabolism and increased versus controls. These findings strongly suggest that in vivo $^1$H MRS may be a useful modality for clinical evaluation of traumatic contusion and could aid in better understanding the neuropathologic process of traumatic contusion induced by FPI. In the present study, in vivo $^1$H MRS was proved to be a useful non-invasive method for in vivo diagnosis and monitoring of posttraumatic metabolism in models of brain contusion.
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Yun-Mi Park,Hwi-Yool Kim 한국피부과학연구원 2021 아시안뷰티화장품학술지 Vol.19 No.1
목적: 본 연구는 국내 10대-40대 여성들을 대상으로 코로나19 발생이 여성들의 화장에 대한 관심도와 사용에 어떠한 변화를 주었 는지를 실증분석을 통해 규명하는데 그 목적이 있다. 방법: 서울시에 거주하는 10대-40대 여성들을 표본집단으로 하여 2020년 9 월 셋째 주부터 넷째 주까지 2주 동안 설문조사를 실시하였으며, 회신된 설문지 300부 가운데 불성실한 응답을 제외하고 유효한 자 료인 271명만 최종 분석에 활용하였다. 결과: 화장에 대한 전반적인 관심도는 코로나19 발생 이후 더 낮아진 것으로 나타났다. 이 는 코로나19 발생 이전에 비해 이후에 화장에 대한 전반적인 관심도와 화장 필요성, 제품 구매, 외모 만족 등이 낮아진 것으로 코로 나19가 여성들의 화장관심도에 영향을 주도 있음을 의미한다. 또한 립 메이크업이나 립스틱과 같은 입술 위주의 화장은 코로나19 발생 이전에 비해 줄어든 것으로 나타나 여성들의 화장품 사용실태에도 영향을 주는 것으로 나타났다. 결론: 본 연구를 통해 코로나 19 발생이 여성들의 화장관심도와 화장품 사용실태에 많은 변화를 주었음을 확인하였다. 코로나19의 장기화가 전망되고 있는 상황 에서 여성들의 화장 관심도와 화장품 사용실태는 더욱 변화될 것이며, 이러한 코로나19 환경에 적합한 다양한 화장품들과 화장방법 들이 유행하여 나타날 것으로 판단된다. Purpose: The purpose of this study is to investigate through empirical analysis how the outbreak of Corona 19 has changed women's interest in and use of makeup in domestic women in their teens to 40s. Methods: A survey was conducted on women in their teens to 40s residing in Seoul from the third week to the fourth week of September 2020, and statistical processing of the collected data was analyzed using the SPSS 26.0 program. Results: The overall interest in makeup was found to have been lower after the outbreak of Corona 19. This means that the overall interest in make-up, the need for make-up, product purchase, and appearance satisfaction have decreased after the outbreak of Corona 19 compared to before the outbreak of Corona 19. In addition, lip-oriented makeup such as lip makeup and lipstick appeared to have decreased compared to before the outbreak of Corona 19, which was found to affect women's use of cosmetics. Conclusion: It has been shown that the mandatory use of masks reduces the purchase of cosmetics and also reduces makeup for beauty purposes by women. In addition, it was found that instead of minimizing makeup on the part (lips) that is not exposed when wearing a mask, makeup on the part (eyes or face) exposed when wearing a mask is rather more interested.
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Biomechanical comparison of bone staple techniques for stabilizing tibial tuberosity fractures
Kyu-Tae Park,Min-Yeong Lee,Hwi-Yool Kim 대한수의학회 2023 大韓獸醫學會誌 Vol.63 No.3
This study compared the biomechanical properties of bone-stapling techniques with those of other fixation methods used for stabilizing tibial tuberosity fractures using 3-dimensionally (3D)-printed canine bone models. Twenty-eight 3D-printed bone models made from computed tomography scan files were used. Tibial tuberosity fractures were simulated using osteotomy. All samples were divided into 4 groups. Group 1 was stabilized with a pin and tension-band wire; group 2, with a pin and an 8 mm-wide bone staple; group 3, with 2 horizontally aligned pins and an 8 mm-wide bone staple; and group 4 with a 10 mm-wide bone staple. Tensile force was applied with vertical distraction until failure occurred. The load and displacement were recorded during the tests. The groups were compared based on the load required to cause displacements of 1, 2, and 3 mm. The maximum failure loads and modes were recorded. The loads at all displacements in group 4 were greater than those in groups 1, 2, and 3. The loads at 1, 2, and 3 mm displacements were similar in groups 1 and 3. There was no significant difference between groups 1 and 3. Groups 1 and 4 provided greater maximum failure loads than groups 2 and 3. Failure occurred because of tearing of the nylon rope, tibial fracture, wire breakage, pin bending, and fracture around the bone staple insertion. In conclusion, these results demonstrate that the bone-stapling technique is an acceptable alternative to tension-band wire fixation for the stabilization of tibial tuberosity fractures in canine bone models.
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