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AVHRR Remote Sensing of Aerosol Microphysics in Global Scale
Higurashi, Akiko,Nakajima, Teruyuki 대한원격탐사학회 1996 International Symposium on Remote Sensing Vol.12 No.1
Satellite remote sensing of microphysical parameters of atmospheric aerosols starts drawing attention of climate community after findings of large global climate effects of aerosols (Charlson et al., 1992) and ship track trail clouds (Coakley et al., 1987). In this situation, there has been considerable effort for developing adequate remote sensing techniques of related aerosol parameters (e.g., Kaufman and Nakajima, 1993; Nakajima and Higurashi, 1996). In this paper, we study a design of retrieval scheme of microphysical parameters of aerosols from multichannel satellite imagers, such as NOAA/AVHRR, ADEOS/ OCTS and ADEOSII/GLI. In this scheme, the optical thickness and effective particle radius of aerosol can be inverted accura~ely from multi-channel analyses of radiances by an efficient look-up table algorithm (Higurashi and Nakajima, 1996; Nakajima et al., 1996) and an iterative inversion algorithm. We have applied our scheme to AVHRR radiance data to produce global map of aerosol microphysical parameters.
A Study of Aerosol and Cloud Interaction with AVHRR and ADEOS/OCTS
Nakajima, Teruyuki,Higurashi, Akiko,Kawamoto, Kazuaki 대한원격탐사학회 1997 International Symposium on Remote Sensing Vol.13 No.1
The TIROS Operational Vertical Sounder (TOVS) instrument is carried on the TIROS-N and NOAA series of satellites. This instrument has a 20 channels High Resolution Infrared Sounder (HIRS) and a 4 channels Microwave Sounding Unit (MSU). These observe the upwelling radiation from the earth and atmosphere. The physical algorithm employed in the retrieval of atmospheric temperature and moisture profiles from the observed radiation involves the computation of weighting functions and synthetic radiometric data for the HIRS and MSU channels. The algorithm is essentially a perturbation method in which guess profiles of temperature and moisture are adjusted on the basis of the differences between the calculated and observed radiances. But there are known shortcomings in the radiative transfer models which can lead to differences which adversely affect the quality of the retrievals. The tuning procedure is necessarily an attempt to ameliorate the effects of these shortcomings. In this work, we use Larrabee Strow/Hal Woolf/PauIVanDelst regression model for HIRS and MSU using FASCD3P line-by-line computation of transmittance to obtain the tuning coefficients such as gamma, bias and RMSE(Root Mean Square Error).
Study aerosol-cloud interaction phenomena from satellite remote sensing and climate modeling
Nakajima, Teruyuki,Higurashi, Akiko,Kawamoto, Kazuaki,Okamoto, Hajime,Takemura, Toshihiko,Kuroda, Shunsuke 대한원격탐사학회 1999 International Symposium on Remote Sensing Vol.15 No.1
We have analyzed AVHRR global data set for obtaining aerosol and cloud microphysical parameters, i. e., optical thickness and size index of particle polydispersions. From the results, it is found that the cloud optical thickness increases with increasing aerosol column number, which seems to be caused mainly by decreasing cloud particle radius. The cloud liquid water path was observed to be relatively constant without a significant dependence on the aerosol number. Further comparison of the satellite results with a general circulation model simulation.
( Eiji Yamada ),( Hidenori Ohkubo ),( Takuma Higurashi ),( Eiji Sakai ),( Hiroki Endo ),( Hirokazu Takahashi ),( Eri Uchida ),( Emi Tanida ),( Nobuyoshi Izumi ),( Akira Kanesaki ),( Yasuo Hata ),( Tet The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.5
Background/Aims: Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk factors for left-sided diverticulitis. We hypothesized that left-sided diverticulitis in Japan is related to obesity and conducted a study of the features and risk factors for this disorder in Japan. Methods: Right-sided di-verticulitis and left-sided diverticulitis patients (total of 215) were compared with respect to background, particularly obesity-related factors to identify risk factors for diverticulitis. Results: There were 166 (77.2%) right-sided diverticulitis patients and 49 (22.8%) left-sided diverticulitis patients. The proportions of obese patients (body mass index ≥25 kg/m2, p=0.0349), viscerally obese patients (visceral fat area ≥100 cm2, p=0.0019), patients of mean age (p=0.0003), and el-derly patients (age ≥65 years, p=0.0177) were significantly higher in the left-sided-diverticulitis group than in the right-sided-diverticulitis group. The proportion of viscerally obese patients was significantly higher in the left-sided-diverticulitis group than in the left-sided-diverticulosis group (p=0.0390). Conclusions: This study showed that obesity, particularly visceral obesity, was a risk factor for left-sided diverticulitis in Japan. (Gut Liver 2013;7:532-538)
Heterogeneous interaction network of yeast prions and remodeling factors detected in live cells
( Chan-gi Pack ),( Yuji Inoue ),( Takashi Higurashi ),( Shigeko Kawai-noma ),( Daigo Hayashi ),( Elizabeth Craig ),( Hideki Taguchi ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.9
Budding yeast has dozens of prions, which are mutually dependent on each other for the de novo prion formation. In addition to the interactions among prions, transmissions of prions are strictly dependent on two chaperone systems: the Hsp104 and the Hsp70/Hsp40 (J-protein) systems, both of which cooperatively remodel the prion aggregates to ensure the multiplication of prion entities. Since it has been postulated that prions and the remodeling factors constitute complex networks in cells, a quantitative approach to describe the interactions in live cells would be required. Here, the researchers applied dual-color fluorescence cross-correlation spectroscopy to investigate the molecular network of interaction in single live cells. The findings demonstrate that yeast prions and remodeling factors constitute a network through heterogeneous protein-protein interactions. [BMB Reports 2017; 50(9): 478-483]
( Yasunari Sakamoto ),( Yusuke Sekino ),( Eiji Yamada ),( Hidenori Ohkubo ),( Takuma Higurashi ),( Eiji Sakai ),( Hiroshi Iida ),( Kunihiro Hosono ),( Hiroki Endo ),( Takashi Nonaka ),( Tamon Ikeda ) 대한소화기기능성질환·운동학회 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.4
Background/Aims The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals. Methods Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (β version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test. Results Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone. Conclusions This study showed that high-viscosity liquid meals delayed gastric emptying: however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals. (J Neurogastroenterol Motil 2011;17:395-401)
( Takashi Nonaka ),( Yusuke Sekino ),( Hiroshi Iida ),( Eiji Yamada ),( Hidenori Ohkubo ),( Eiji Sakai ),( Takuma Higurashi ),( Kunihiro Hosono ),( Hiroki Endo ),( Tomoko Koide ),( Hirokazu Takahashi 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.2
The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the 13C-acetic acid breath test. Methods Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg 13C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (β and k), calculated by using the 13CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically. Results No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or β and k, were observed between the 2 test conditions. Conclusions The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.
Natural History of Chronic Intestinal Pseudo-obstruction and Need for Palliative Care
Kosuke Tanaka,Hidenori Ohkubo,Atsushi Yamamoto,Kota Takahashi,Yuki Kasai,Anna Ozaki,Michihiro Iwaki,Takashi Kobayashi,Tsutomu Yoshihara,Noboru Misawa,Akiko Fuyuki,Shingo Kato,Takuma Higurashi,Kunihiro 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.3
Background/AimsNatural history of chronic intestinal pseudo-obstruction (CIPO), a rare disease characterized by episodes of non-mechanical obstruction, is unclear in adults. This study evaluates the clinical course of CIPO and palliative care needs of patients. MethodsFrom October 2010 to September 2021, 74 patients who underwent cine MRI and had a definitive diagnosis of CIPO were prospectively included. We investigated disease etiology and outcomes, age at onset, nutritional status at consultation (body mass index and serum albumin), hydrogen breath test results, and total parenteral nutrition (TPN) during the disease course. ResultsForty-seven patients (64%) were women, with a mean age of 44 years at onset and 49 years at diagnosis. Primary CIPO was observed in 48 patients (65%). Secondary CIPO was observed in 26 cases (35%), of whom 18 (69%) had scleroderma. The mean body mass index, serum albumin level, and hydrogen breath test positivity rate were 17 kg/m2, 3.8 mg/dL, and 60%, respectively. TPN and invasive decompression therapy were required by 23 (31%) and 18 (24%) patients, respectively. Intestinal sterilization was performed in 51 (69%) patients and was effective in 33 (65%); of these, 28 (85%) were taking metronidazole. Seven (9%) patients used opioids. There were 9 deaths (12%), including 5 (56%) from infection and 2 (22%) from suicide. Of the deaths, 6 (67%) and 4 (44%) underwent TPN management and decompression therapy, respectively. Fifty-one patients (69%) wanted palliative care. ConclusionCIPO is a rare, severe, and under-recognized disease. Standardization of treatment strategies, including palliative care and psychiatric interventions, is desired.