Low-dose Radiation Induces Antitumor Effects and Erythrocyte System Hormesis

Yu, Hong-Sheng,Liu, Zi-Min,Yu, Xiao-Yun,Song, Ai-Qin,Liu, Ning,Wang, Hao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Objective: Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. Methods: Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the right inguen as an experimental in situ animal model. Six hours before implantation, the mice were given 75mGy whole body X-ray radiation. Tumor growth was observed 5 days later, and the tumor volume was calculated every other day. Fifteen days later, all mice were killed to measure the tumor weight, and to observe necrotic areas and tumor-infiltration-lymphoreticular cells (TILs). At the same time, erythrocyte immune function and the level of 2,3-diphosphoglyceric acid (2,3-DPG) were determined. Immunohistochemical staining was used to detect the expression of EPO and VEGFR of tumor tissues. Results: The mice pre-exposed to low dose radiation had a lower tumor formation rate than those without low dose radiation (P < 0.05). The tumor growth slowed down significantly in mice pre-exposed to low dose radiation; the average tumor weight in mice pre-exposed to low dose radiation was lighter too (P < 0.05). The tumor necrosis areas were larger and TILs were more in the radiation group than those of the group without radiation. The erythrocyte immune function, the level of 2,3-DPG in the low dose radiation group were higher than those of the group without radiation (P < 0.05). After irradiation the expression of EPO of tumor tissues in LDR group decreased with time. LDR-24h, LDR-48h and LDR-72h groups were all statistically significantly different from sham-irradiation group. The expression of VEGFR also decreased, and LDR-24h group was the lowest (P < 0.05). Conclusion: Low dose radiation could markedly increase the anti-tumor ability of the organism and improve the erythrocyte immune function and the ability of carrying $O_2$. Low-dose total body irradiation, within a certain period of time, can decrease the expression of hypoxia factor EPO and VEGFR, which may improve the situation of tumor hypoxia and radiosensitivity of tumor itself.

Prognostic Role of C-reactive Protein in Gastric Cancer: A Meta-analysis

Yu, Qing,Yu, Xiong-Fei,Zhang, Shou-De,Wang, Hao-Hao,Wang, Hai-Yong,Teng, Li-Song Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: A number of studies have investigated the association between increased pretreatment serum C-reactive protein (CRP) levels and the prognosis of gastric cancer. However, due to the inconsistent results, whether the serum CRP level can be a prognostic factor in primary gastric cancer remains controversial. Methods: We searched Medline, PubMed, Embase and the Cochrane Central Register of Controlled Trials for relevant high-quality reports. A meta-analysis was carried out using the included studies to assess the association between pretreatment serum CRP level and overall survival (OS) in patients with gastric cancer. Correlation analyses were conducted to evaluate the relationship between serum CRP and tumor characteristics such as tumor node metastasis (TNM) stage and recurrence. Results: Twelve reports involving 2,597 patients with gastric cancer were included. Primary meta-analysis indicated a significant association between elevated CRP level and poor OS (HR 1.77, 95% CI 1.56-2.00). Subgroup analyses showed no single factor could alter the primary results when we divided the included studies by "number of patients", "max follow-up period", "TNM stage", "treatment" and "cut-off value". Correlation analyses showed that serum CRP level was significantly related to TNM stage (OR 2.96, 95% CI 2.22-3.93) and tumor recurrence (OR 1.81, 95% CI 1.21-2.71). Conclusions: We demonstrated that increased pretreatment serum CRP level (${\geq}10mg/L$) was significantly associated with poor prognosis in gastric cancer patients, either in early or advanced stages.

Chiral Pool Synthesis of N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine from L-Malic acid

Hao, Bao-Yu,Liu, Jin-Qiang,Zhang, Wei-Han,Chen, Xin-Zhi Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5

A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and more than 98% ee.

Evaluation of Emergency Management Capability in Chinese College Based on CMM Model

Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2

Emergencies occur in colleges from time to time in recent years, which disturbs teaching and campus life seriously and causes pressure to students and teachers’ mind and hurt of their life. With emergencies happening frequently, it is the need of social development and also the need of maintaining the development and stability of higher education to constantly improve emergency management capability and to prevent and deal with the emergencies scientifically and efficiently. Emergency management capability decides the response level of a university when they emergencies happen. The improvement of the capacity is a process step by step with many stages for different stage requires different capability. This paper constructs the maturity model and evaluation index system of emergency management capability according to CMM and examines it with real data of a university in Henan Province. Result shows that the level of emergency management capability of the university is initial. Correspond with the university’s situation, the result is accurate and reliable and is able to provide reference for finding questions in the process of emergency management, reducing the risk of emergency and improving emergency management capability.

Studies on China s Emergency Management Evaluation Based on Meta-analysis Method : Review and Prospect

Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2

Emergency assessment is an important field of the current emergency management research. Foreign related research started earlier and progress rapidly, has a wealth of practical experience, the domestic research is in the stage of exploration. This paper will be introduced to the Meta - analysis method for evaluation of emergency management research, from the perspective of the overall comprehensive analysis of emergency management evaluation and the research itself, the emergency management at home and abroad in the evaluation of excavated in a large number of research literature in the field of general trends and characteristics, by summing up experience and the existing research results, the theoretical research and practice of emergency management evaluation by weak links that exist in the analysis, in order to find the deficiencies in the study of emergency management assessment, for the future development strategy and establish and improve the basis for policy.

Analysis of Dangerous Chemical Accident Cause Based on Apriori Algorithm

Hao Yu 위기관리 이론과 실천 2016 Journal of Safety and Crisis Management Vol.6 No.1

In order to identify the association between causes of accidents due to hazardous chemicals, clear and definite the key points of safety supervision, and improve the efficiency of security supervision, this study researches 150 accident investigation report as data source by data mining technology, A priori algorithm, and finds out the relationship between factors such as time, step, type, severity and cause. By analyzing the 8 valuable rules, it proposes 4 suggestions for improving key safety supervision, thus to promote the optimization of safety supervision strategy of hazardous chemicals.

Sublimable materials facilitate the TEM sample preparation of oil-soluble nanomaterials

Yu-Hao Deng 한국현미경학회 2020 Applied microscopy Vol.50 No.1

Sample preparation is significantly important to the high-resolution transmission electron microscopy (HRTEM) characterization of nanomaterials. However, many general organic solvents can dissolve the necessary organic polymer support layer in TEM grid, which causes it difficult to obtain high-quality samples of oil-soluble nanomaterials. In this study, a new sample preparation method for oil-soluble nanomaterials has been developed by using the sublimable material as a transition layer. Experiments also show that there is no damage to TEM grids and high-quality HRTEM images can be obtained via this method. This approach paves the way to applicable HRTEM sample preparation of oil-soluble nanomaterials.

Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese

Hao, Yu-Xia,Wang, Jun-Ping,Zhao, Long-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Aim: Associations between polymorphisms in miR-146aG>C, miR-196a2C>T and miR-499A>G and risk of HCC, and interaction with HBV infection in a Chinese population, were the target of the present research. Methods: The duplex polymerase-chain-reaction with confronting-two-pair primers (PCR-RFLP) was performed to determine the genotypes of the miR-146aG>C, miR-196a2C>T and miR-499A>G genotypes. Associations of polymorphisms with the risk of HCC were estimated by conditional logistic regression analysis. Results: Drinking, family history of cancer, HBsAg and HCV were risk factors for HCC. Multivariate regression analyses showed that subjects carrying the miR-196a2 CC genotype had significantly increased risk of HCC, with an adjusted OR (95% CI) of 2.18 (1.23-3.80). In addition, cases carrying the miR-196a2 C allele had a 1.64-fold increase in the risk for HCC (95%CI=1.03-2.49). The miR-196a2 CT and TT genotypes greatly significantly increased the risk of HCC in subjects with HBV infection, with adjusted ORs (95% CI) of 2.02 (1.12-3.68) and 2.69 (1.28-5.71), respectively. Conclusion: Our results demonstrate that miR-196a2 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection.

IoT-base Generic Intelligent Wireless Sensing Platform for Real-time Data Collection and Distribution Data Analysis

( Yu-cheng Yang ),( Kai-sheng Tseng ),( Xiang-yu Huang ),( Sheng-hao Chen ),( Joe-air Jiang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

In this study, a generic intelligent wireless sensing platform with the IoT and wireless transmission technology is established for greenhouse monitoring, which is capable of greenhouse data collection and analysis. The data analyzed by a cloud server would provide important information regarding the efficiency of greenhouse management and cultivation methods. To monitor greenhouse related parameters, an embedded board is placed in a greenhouse as the gateway. Monitoring data and images collected by sensors deployed in the greenhouse are transmitted to the embedded board via an Ethernet or wireless transmission module. The data are eventually sent to a database by wireless AP. The AP connects to the internet by using a 4G USB dongle, which can provide sufficient data transmission speed for real-time data transmission. In wireless hotspots and areas with Wi-Fi, not only can images be transmitted to the cloud, but also can the mobile APP be used to perform remote monitoring, so experimental observations are no longer affected by geographical impacts. Moreover, to ensure the preservation of images and numeric data, the gateway carries a high durability secure digital (SD) memory card to store images and data; if the network encounters some problems, such as unable to connect and a lack of network traffic, the data can be stored in the SD card. Thus, the proposed platform is able to perform heavy information transmission duties and support performing all wireless monitoring tasks. In addition, the analyzed data can be used by agricultural personnel to provide critical cultivation suggestions.

Die Design and Numerical Simulation for the Die Forging Forming of Shifting Fork

Yu, Hao,Jung, Dong Won,Kim, Dong Hong Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.909 No.-

<P>At present, the domestic most use the traditional machining methods of production, such as general milling, drill, ground, etc. But the traditional processing method is low material utilization ratio, time-consuming power consumption, and low production efficiency. as the same time the product quality is difficult to meet the requirement of high strength. In contrast, shifting fork forming die forging can improve labor productivity, and can obtain the ideal parts surface roughness and size accuracy. And with the forming of die forging the variable speed fork general rarely cutting processing, just in require special high points will has fine grinding. This design has completed the variable speed fork of die forging shape of mold design giving the design plan and design process. This topic is about the design of the numerical simulation, getting the expected of the press one.</P>