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Moussa Manal H.,Hamam Ghada G.,Abd Elaziz Asmaa E.,Rahoma Marwa A.,Abd El Samad Abeer A.,El-Waseef Dalia A. A.,Hegazy Mohamed A. 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.6
Background: Skeletal muscle injuries are frequent clinical challenges due to associated fibrosis and disability. Regenerative medicine is an emerging promising strategy for such cases. The aim of this study was to compare between the effects of bone marrow-mesenchymal stem cells (BM-MSCs) versus adipose tissue stromal cells (ADSCs) on regeneration and re-innervation of skeletal muscle laceration injury in Wistar rats at different time intervals. Methods: Six young male rats were used as a source of allogenic MSCs. Eighty-four adult female rats were divided into: Group I (control), Group II (Untreated Laceration): right gluteal muscle was lacerated and left for spontaneous healing, Group III (BM-MSCs): right gluteal muscle was lacerated with concomitant local intramuscular injection of 1 × 106 BM-MSCs in the lacerated muscle, Group IV (ADSCs): right gluteal muscle was lacerated with concomitant local intramuscular injection of 1 × 106 ADSCs in lacerated muscle. Rats were sacrificed after one, two and eight weeks. Muscles were processed to prepare sections stained with H&E, Mallory’s trichrome and immune-histochemical staining (neurofilament light chain). Results: A significant increase in collagen fibers and failure of re-innervation were noticed in untreated laceration group. BM-MSCs-treated groups showed regeneration of muscle fibers but with increased collagen fibers. Meanwhile, ADSCs showed better regenerative effects evidenced by significant increase in the number of myotubes and significant decrease in collagen deposition. Re-innervation was noticed in MSCs-injected muscles after 8 weeks of laceration. Conclusion: Both BM-MSCs and ADSCs improved regeneration of skeletal muscle laceration injury at short- and long-term durations. However, fibrosis was less in ADSCs-treated rats. Effective re-innervation of injured muscles occurred only at the long-term duration.
A Marwa Elbouz,Ayman Alfalou,Habib Hamam 보안공학연구지원센터 2008 International Journal of Hybrid Information Techno Vol.1 No.2
In our society based on communication, the barrier between the spoken and gestural languages remains a main problem for the deaf-mute. To make this communication possible, we propose developing an interface using mobile phone camera with a module of recognition allowing the recognition and the restitution of the sign language in the form of synthesized words. This module is based on a spectral comparison between the image to recognize and a correlation multidecision segmented filter resulting from images reference coming from a predetermined database: correlation technique. The latter has been used for a long time to recognize a target image. However an adaptation of this technique is necessary to take into account particular characteristics of gestures (for which the target image to recognize evolves in time) and to be able to send it with a high transmission rate. Thus to obtain a reliable decision, the module of recognition must carry out a very large number of correlations, which slows down the translation process. In order to reduce this processing time, we propose implementing our recognition module by using multipost technique “PVM”. This technique is based on the distribution of calculation on various stations in parallel. This technique enables us to distribute the required computing effort on various parallel stations using (PVM) a Parallel Virtual Machine. It showed significant gains in computing time but not sufficiently for a real-time translation (mobile phone communication). To further reduce processing time, we propose adding a Comprehension Pre-selection module to the initial recognition module. The former is based on the division of images (resulting from the gesture target) in various zones, in order to reduce and eliminate all the improbable gestures, according to the positions of hands. Thus, we reduce the needed identification time.
Color Video Sequences Encryption/Decryption Processes Using Several Color Keys Images
Rami El Sawda,Ayman Alfalou,Habib Hamam 보안공학연구지원센터 2008 International Journal of Security and Its Applicat Vol.2 No.2
An optical encrypted color video sequence based on a spectral fusion of information has been proposed. Each color image of the sequence is decomposed into three basic color components. Pertinent information fusion is considered as segmentation. Encrypting consists in modulating each of these three components of the image spectrum by a corresponding phase mask. This phase mask includes pertinent information collected from various encrypted color keys according to a fusion criterion. As encrypting keys are formed by real images, it becomes an impossible task to get the target image by any trial and error random images techniques. For decrypting, a simple algorithm based on segmented correlation filters is proposed. Simulation results corroborate the effectiveness of our algorithm.
Phase equilibria behavior of carbon dioxide-n-hexane-naphthalene ternary system
Inas Muen AlNashef,Rasheed S. Al-Ameeri,Taher A. Al Sahhaf,Salah E. M. Hamam 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.6
The ternary system CO2-n-hexane-naphthalene was studied to determine the bubble point pressure at three different temperatures (40, 60 and 80 oC) and a fixed n-hexane to naphthalene mole ratio of 9 : 1. The experimental data obtained were predicted by using the Peng-Robinson equation of state with two interaction parameters. The experimental and calculated bubble point pressures were generally in good agreement at the three temperatures and over the composition range investigated.
Integrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomas
Machino Hidenori,Dozen Ai,Konaka Mariko,Komatsu Masaaki,Nakamura Kohei,Ikawa Noriko,Shozu Kanto,Asada Ken,Kaneko Syuzo,Yoshida Hiroshi,Kato Tomoyasu,Nakayama Kentaro,Saloura Vassiliki,Kyo Satoru,Hamam 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological malignancy. To date, the profiles of gene mutations and copy number alterations in HGSOC have been well characterized. However, the patterns of epigenetic alterations and transcription factor dysregulation in HGSOC have not yet been fully elucidated. In this study, we performed integrative omics analyses of a series of stepwise HGSOC model cells originating from human fallopian tube secretory epithelial cells (HFTSECs) to investigate early epigenetic alterations in HGSOC tumorigenesis. Assay for transposase-accessible chromatin using sequencing (ATAC-seq), chromatin immunoprecipitation sequencing (ChIP-seq), and RNA sequencing (RNA-seq) methods were used to analyze HGSOC samples. Additionally, protein expression changes in target genes were confirmed using normal HFTSECs, serous tubal intraepithelial carcinomas (STICs), and HGSOC tissues. Transcription factor motif analysis revealed that the DNA-binding activity of the AP-1 complex and GATA family proteins was dysregulated during early tumorigenesis. The protein expression levels of JUN and FOSL2 were increased, and those of GATA6 and DAB2 were decreased in STIC lesions, which were associated with epithelial-mesenchymal transition (EMT) and proteasome downregulation. The genomic region around the FRA16D site, containing a cadherin cluster region, was epigenetically suppressed by oncogenic signaling. Proteasome inhibition caused the upregulation of chemokine genes, which may facilitate immune evasion during HGSOC tumorigenesis. Importantly, MEK inhibitor treatment reversed these oncogenic alterations, indicating its clinical effectiveness in a subgroup of patients with HGSOC. This result suggests that MEK inhibitor therapy may be an effective treatment option for chemotherapy-resistant HGSOC.