Facial Nerve Repair following Acute Nerve Injury

Ehud Fliss,Ravit Yanko,Arik Zaretski,Roei Tulchinsky,Ehud Arad,Daniel J. Kedar,Dan M. Fliss,Eyal Gur 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.4

Background Acute facial nerve iatrogenic or traumatic injury warrants rapid management with the goal of reestablishing nerve continuity within 72 hours. However, reconstructive efforts should be performed up to 12 months from the time of injury since facial musculature may still be viable and thus facial tone and function may be salvaged. Methods Data of all patients who underwent facial nerve repair following iatrogenic or traumatic injury were retrospectively collected and assessed. Paralysis etiology, demographics, operative data, postoperative course, and outcome were examined. Results Twenty patients underwent facial nerve repair during the years 2004 to 2019. Data were available for 16 of them. Iatrogenic injury was the common category (n¼13, 81%) with parotidectomy due to primary parotid gland malignancy being the common surgery (n¼7, 44%). Nerve repair was most commonly performed during the first 72 hours of injury (n¼12, 75%) and most of the patients underwent nerve graft repair (n¼15, 94%). Outcome was available for 12 patients, all of which remained with some degree of facial paresis. Six patients suffered fromcomplete facial paralysis (50%) and three underwent secondary facial reanimation (25%). There were no major operative or postoperative complications. Conclusion Iatrogenic and traumatic facial nerve injuries are common etiologies of acquired facial paralysis. In such cases, immediate repair should be performed. For patients presenting with facial paralysis following previous surgery or trauma, nerve repair should be considered up to at least 6 months of injury. Longstanding paralysis is best treated with standard facial reanimation procedures.

헤롯의 무덤에 관한 연구 Ⅰ

Ehud Netzer,박종수 한국성서고고학회 2013 성경과 고고학 Vol.- No.78

헤롯의 무덤에 관한 연구(Ⅱ)

Ehud Netzer,박종수 한국성서고고학회 2014 성경과 고고학 Vol.- No.79

Association of the time that elapsed from last vaccination with protective effectiveness against foot-and-mouth disease in small ruminants

Ehud Elnekave,Boris Even-Tov,Boris Gelman,Beni Sharir,Eyal Klement 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.1

Routine and emergency vaccination of small ruminants against foot-and-mouth disease (FMD) is mandatory in many endemic countries, yetdata on the field effectiveness of the vaccines used is scarce. We conducted an investigation of a serotype O FMD outbreak that took placein a sheep and goat pen, and estimated the effectiveness of various routine vaccination statuses. We also evaluated the protection providedby colostrum administration and emergency vaccination. Animals which were routinely vaccinated twice were not clinically affected whiledisease incidence was observed among animals routinely vaccinated only once (p = 0.004 according to a two-sided Fisher’s exact test). Ingroups vaccinated only once, there was a significant association between the average time that elapsed since last vaccination and the diseaseincidence (n = 5; Spearman correlation coefficient: rs = 1.0, p < 0.01). In addition, non-vaccinated lambs fed colostrum from dams vaccinatedmore than 2 months before parturition had a mortality rate of 33%. Administration of emergency vaccination 2 days after the occurrence ofthe index case was the probable reason for the rapid blocking of the FMD spread within 6 days from its onset in the pen.

Translation and Transcription: the Dual Functionality of LysRS in Mast Cells

Ehud Razin,Nurit Yannay-Cohen 한국분자세포생물학회 2006 Molecules and cells Vol.22 No.2

Oral Administration of β-Glucosylceramide for the Treatment of Insulin Resistance and Nonalcoholic Steatohepatitis: Results of a Double-Blind, Placebo-Controlled Trial

Gadi Lalazar,Ehud Zigmond,Sarah Weksler-Zangen,Ami Ben Ya’acov,Miriam Sklair Levy,Nilla Hemed,Itamar Raz,Yaron Ilan 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.5

β-glucosylceramide (GC) is a naturally occurring glycosphingolipid that was shown to improve hepatic steatosis, steatohepatitis, and insulin resistance in animal models of nonalcoholic fatty liver disease. In this study, we evaluated the safety and efficacy of oral administration of GC in subjects with nonalcoholic steatohepatitis (NASH). Twenty-three patients with biopsy proven NASH were enrolled in a double-blind, placebo-controlled trial. Patients were orally administered daily with 7.5 mg of GC. Patients were followed for safety, liver enzymes, HbA1c, insulin sensitivity, lipid profile, hepatic fat content as measured by magnetic resonance imaging (MRI), and NASH score on liver biopsy. No treatment-related adverse events were observed during treatment. In a per protocol analysis of data, oral administration of GC decreased the hepatic fat content as measured by MRI in GC-treated compared with placebo. HbA1C decreased in patients treated with GC. GC treatment was associated with a milder decrease in the high-density lipoprotein serum levels. The beneficial effects were associated with a decrease in CD4 and NKT cell subsets of lymphocytes. Due to the small number of subjects enrolled, differences did reach statistical significance. Oral administration of GC is safe and biologically active in patients with NASH and insulin resistance.

Multiple Roles of the SO[Formula]/Cl⁻/OH⁻ Exchanger Protein Slc26a2 in Chondrocyte Functions

Park, Meeyoung,Ohana, Ehud,Choi, Soo Young,Lee, Myeong-Sok,Park, Jong Hoon,Muallem, Shmuel American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.4

<P>Mutations in the SO[Formula]/Cl<SUP>−</SUP>/OH<SUP>−</SUP> exchanger Slc26a2 cause the disease diastrophic dysplasia (DTD), resulting in aberrant bone development and, therefore, skeletal deformities. DTD is commonly attributed to a lack of chondrocyte SO[Formula] uptake and proteoglycan sulfation. However, the skeletal phenotype of patients with DTD is typified by reduction in cartilage and osteoporosis of the long bones. Chondrocytes of patients with DTD are irregular in size and have a reduced capacity for proliferation and terminal differentiation. This raises the possibility of additional roles for Slc26a2 in chondrocyte function. Here, we examined the roles of Slc26a2 in chondrocyte biology using two distinct systems: mouse progenitor mesenchymal cells differentiated to chondrocytes and freshly isolated mouse articular chondrocytes differentiated into hypertrophic chondrocytes. Slc26a2 expression was manipulated acutely by delivery of Slc26a2 or shSlc26a2 with lentiviral vectors. We demonstrate that slc26a2 is essential for chondrocyte proliferation and differentiation and for proteoglycan synthesis. Slc26a2 also regulates the terminal stage of chondrocyte cell size expansion. These findings reveal multiple roles for Slc26a2 in chondrocyte biology and emphasize the importance of Slc26a2-mediated protein sulfation in cell signaling, which may account for the complex phenotype of DTD.</P>

Automated atomically precise lithography over multiple length scales for complete nanodevice fabrication

James OWEN,Joshua BALLARD,Scott SCHMUCKER,Ehud FUCHS,John RANDALL,James VON EHR,Bjorn PIGLOSIEWICZ 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Direct Detection of Reactive Nitrogen Species in Experimental Autoimmune Uveitis

Bae, Sun Ryang,Wu, Guey Shuang,Sevanian, Alex,Schultz, Brian E.,Zamir, Ehud,Rao, Narsing A. The Korean Ophthalmological Society 2007 Korean Journal of Ophthalmology Vol.21 No.1

<P><B>Purpose</B></P><P>Demonstrate unequivocally the generation of nitric oxide in experimental autoimmune uveoretinitis by electron spin resonance spectroscopy (ESR) using ferrous iron complex of N-methyl-D-glucamine dithiocarbamate, (MGD)<SUB>2</SUB>-Fe<SUP>2+</SUP>, as a spin trap.</P><P><B>Methods</B></P><P>Experimental autoimmune uveitis was induced in Lewis rats, and at the peak of the intraocular inflammation, the animals received intravitreous injections of the spin trap. The retina and choroid dissected from the enucleated globes were subjected to ESR. Similarly, the retina and choroid obtained at the peak of experimental autoimmune uveo-retinitis (EAU) were placed in a vial containing luminal, and chemiluminescence was counted on a Packard liquid scintillation analyzer.</P><P><B>Results</B></P><P>The ESR three-line spectrum (g=2.04; a<SUB>N</SUB>=12.5 G) obtained was characteristic of the adduct [(MGD)<SUB>2</SUB>-Fe<SUP>2+</SUP>-NO]. The majority of this signal was eliminated by the inducible nitric oxide synthase (iNOS) specific inhibitor aminoguanidine injected inflamed retina was detected when compared with that of the non inflamed controls. The chemiluminescent activity was further increased two-fold by the addition of bicarbonate to the inflamed retina; the phenomenon is attributable only to the presence of a high steady-state concentration of peroxynitrite.</P><P><B>Conclusions</B></P><P>The study shows an unequivocal presence of nitric oxide in EAU retina and choroid and the generation of peroxynitrite. High levels of these reactive nitrogen species generated in the inflamed retina and choroids are certain to cause irreversible tissue damage, especially at the susceptible sites such as photoreceptors.</P>

Acupuncture Treatment in Geriatric Rehabilitation: A Retrospective Study

Shahar Lev-ari,Yaffa Lerman,David Goldray,Shifra Merdler,Ehud Miller,Yair Maimon,Adi Barad 사단법인약침학회 2008 Journal of Acupuncture & Meridian Studies Vol.1 No.1

The main goal of geriatric rehabilitation reconditioning following an acute illness is rapid restoration of normal activity. Key elements are pain control, restoration of bowel function, sleep, appetite and general well being, alongside physical activity. The aim of this retrospective study was to assess the effect of acupuncture as an adjunct to medical and physical rehabilitation in geriatric patients. The setting was a university-affiliated large city general hospital. The participants comprised 27 consenting consecutive patients in a subacute geriatric rehabilitation department. The interventions consisted of biweekly acupuncture treatment in conjunction with medical and physical therapy. The outcome measures of pain, appetite, quality of sleep, bowel function and general well being were assessed using a 10-point Likert scale at the onset and close of treatment. The results showed that a significant post-treatment improvement was seen in pain (p = 0.005), appetite (p = 0.0034), bowel function (p = 0.029) and general well being (p = 0.0012) scores in patients' treatment when compared with pretreatment baseline scores. The “quality of sleep” score showed a trend towards improvement (p = 0.073). In conclusion, acupuncture may be beneficial as an adjunctive treatment in geriatric postacute illness rehabilitation. Randomized controlled trials are needed to further assess the role of acupuncture as part of treatment management for restoring normal physical activity in geriatric patients. The main goal of geriatric rehabilitation reconditioning following an acute illness is rapid restoration of normal activity. Key elements are pain control, restoration of bowel function, sleep, appetite and general well being, alongside physical activity. The aim of this retrospective study was to assess the effect of acupuncture as an adjunct to medical and physical rehabilitation in geriatric patients. The setting was a university-affiliated large city general hospital. The participants comprised 27 consenting consecutive patients in a subacute geriatric rehabilitation department. The interventions consisted of biweekly acupuncture treatment in conjunction with medical and physical therapy. The outcome measures of pain, appetite, quality of sleep, bowel function and general well being were assessed using a 10-point Likert scale at the onset and close of treatment. The results showed that a significant post-treatment improvement was seen in pain (p = 0.005), appetite (p = 0.0034), bowel function (p = 0.029) and general well being (p = 0.0012) scores in patients' treatment when compared with pretreatment baseline scores. The “quality of sleep” score showed a trend towards improvement (p = 0.073). In conclusion, acupuncture may be beneficial as an adjunctive treatment in geriatric postacute illness rehabilitation. Randomized controlled trials are needed to further assess the role of acupuncture as part of treatment management for restoring normal physical activity in geriatric patients.