Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium

Cote, M.L.,Liu, M.,Bonassi, S.,Neri, M.,Schwartz, A.G.,Christiani, D.C.,Spitz, M.R.,Muscat, J.E.,Rennert, G.,Aben, K.K.,Andrew, A.S.,Bencko, V.,Bickeboller, H.,Boffetta, P.,Brennan, P.,Brenner, H.,Due Pergamon Press 2012 European journal of cancer Vol.48 No.13

Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR)=1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR=1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR=1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.

CORE AND GLOBAL PROPERTIES OF EARLY-TYPE GALAXIES AND THEIR GLOBULAR CLUSTER SYSTEMS

Cote, Patrick,The Acs Virgo And Fornax Cluster Survey Teams, The Acs Virgo And Fornax Cluster Survey Teams The Korean Astronomical Society 2010 天文學論叢 Vol.25 No.3

The core and global properties of the early-type ("red sequence") galaxies in the Virgo and Fornax clusters are examined using high-quality HST/ACS imaging for 143 galaxies. Rather than dividing neatly into disparate populations having distinct formation and/or evolution histories, many of the core and global properties of these galaxies show smooth and systematic variations along the galaxy luminosity function. The few examples of the rare class of compact elliptical galaxies in our sample all show properties that are strongly suggestive of tidal stripping by massive galaxies; if so, then these systems should not be viewed as populating the low-luminosity extension of so-called "normal" elliptical sequences. These results demonstrate that complete and/or unbiased samples are a pre-requisite for identifying the physical mechanisms that gave rise to the early-type galaxies we observe locally, and how these mechanisms varied with mass and environment.

Towards a Definition of Excellence in Sport Coaching

Jean Cote,Bradley Young,Julian North,Patrick Duffy 한국코칭능력개발원 2007 International Journal of Coaching Science Vol.1 No.1

A Tension Distribution Algorithm for Cable-Driven Parallel Robots Operating Beyond their Wrench-Feasible Workspace

Alexis Fortin Cote,Philippe Cardou,Clement Gosselin 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10

One of the main concerns in the control of over-constrained cable driven parallel mechanisms is the handling of the tension distribution, which is crucial to the proper mechanism behaviour. For example, it dictates the power consumption and stiffness of the mechanism. One problem that remains to be addressed is the handling of cable tensions when the end-effector moves beyond its wrench-feasible workspace, a situation that can arise when the robot is used as a haptic interface. Most existing algorithms are capable of determining whether a specified wrench is unfeasible, but cannot return a suitable second-best tension distribution in such situations. This paper presents an algorithm based on quadratic programming that is capable of handling these situations in real time. The algorithm provides the exact tension distribution for exerting the prescribed wrench when the end-effector is inside the robot workspace. Moreover, when the end-effector is outside of the robot workspace, the algorithm returns a tension distribution that approximately generates the prescribed wrench. The effectiveness of the algorithm is first illustrated using the simulation of a simple cable-driven parallel robot (CDPR). Experimental results are then provided for an eight-cable six-degree-of-freedom CDPR using a real-time implementation.

Multiple Phosphoinositide - specific Phospholipase C in Oat Roots

Gary G . Cote 忠北大學校 遺傳工學硏究所 1995 遺傳工學硏究 Vol.9 No.1

STRATEGIC ENTREPRENEURIALISM IN ANALYSIS: GLOBAL PROBLEMS IN RESEARCH

Shawn M Carraher,M Ronald Buckley,Joseph A Cote People&Global Business Association 2000 Global Business and Finance Review Vol.5 No.2

A decade ago, a series of published articles debated the amount of method variance in organizational measures from all over' the world (Bagozzi and Yi, 1990; Spector, 1987; Williams, Cote, and Buckley, 1989). Interestingly, while all three studies analyzed the same data sets, they reached different conclusions concerning the presence of method variance. Spector (1987) reported that method effects were relatively minor, Bagozzi and Yi (1990) found them to be of moderate importance, and Williams et al. (1989) found method effects to be quite pervasive. Up to this time, no one has offered reasonable explanations as to why these results were found. While some of the differences in results may be due to the use of different analytic methods; even the use of the same technique (Confirmatory Factor Analysis - CFA) resulted in different conclusions. The differences found by these researchers (Bagozzi and Yi, 1990; Williams et al., 1989) are likely due to the multiple solutions problem caused by factor indeterminacy which is common with factor analytic techniques which is likely to exist with domestic and international data (Cattell and Gorsuch, 1963; Gorsuch, 1974; 1983; Rozeboom, 1992). A series of simulations were performed which indicate that there are, in fact, many reasonable solutions which can be fit to MTMM data using CFA and that therefore it appears that the multiple solutions problem is also significant for CFA as it is for other factor analytic methods. Some possible remedies for the problem of fitting MTMM models are proposed. We suggest that researchers need to be adaptable in the analytic methods which they employ and the topics that they explore (entrepreneurial researchers) and to carefully examine their data so that the research questions match the capabilities of the techniques utilized.

VUV-Sensitive Silicon Photomultipliers for Xenon Scintillation Light Detection in nEXO

Retiere, F.,Cote, M.,HoBl, J.,Krucken, R. Professional Technical Group on Nuclear Science 2018 IEEE transactions on nuclear science Vol.65 No.11

<P>Future ton-scale liquefied noble gas detectors depend on efficient light detection in the vacuum ultraviolet (VUV) range. In the past years, silicon photomultipliers (SiPMs) have emerged as a valid alternative to standard photomultiplier tubes or large-area avalanche photodiodes. The next-generation double-beta decay experiment, nEXO, with a 5-ton liquid xenon time projection chamber will use SiPMs for detecting the 175-nm xenon scintillation light, in order to achieve an energy resolution of <TEX>$\boldsymbol {\sigma }/\boldsymbol {Q_{\beta \beta }} = 1$</TEX>%. This paper presents recent measurements of the VUV-HD generation SiPMs from Fondazione Bruno Kessler, Trento, Italy, in two complementary setups. It includes measurements of the photon-detection efficiency (PDE) with gaseous xenon scintillation light in a vacuum setup and dark measurements in a dry nitrogen gas setup. We report improved PDE at 175 nm compared to previous generation devices that would meet the criteria of nEXO. Furthermore, we present the projected nEXO detector light collection and energy resolution that could be achieved by using these SiPMs.</P>

Robust Control of Current Controlled PWM Rectifiers Using Type-2 Fuzzy Neural Networks for Unity Power Factor Operation

Acikgoz, Hakan,Coteli, Resul,Ustundag, Mehmet,Dandil, Besir The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.2

AC-DC conversion is a necessary for the systems that require DC source. This conversion has been done via rectifiers based on controlled or uncontrolled semiconductor switches. Advances in the power electronics and microprocessor technologies allowed the use of Pulse Width Modulation (PWM) rectifiers. In this paper, dq-axis current and DC link voltage of three-phase PWM rectifier are controlled by using type-2 fuzzy neural network (T2FNN) controller. For this aim, a simulation model is built by MATLAB/Simulink software. The model is tested under three different operating conditions. The parameters of T2FNN is updated online by using back-propagation algorithm. The results obtained from both T2FNN and Proportional + Integral + Derivate (PID) controller are given for three operating conditions. The results show that three-phase PWM rectifier using T2FNN provides a superior performance under all operating conditions when compared with PID controller.

Molecular Modeling Study on Morphine Derivatives Using Density Functional Methods and Molecular Descriptors

Cotua, Jose,Cotes, Sandra,Castro, Pedro,Castro, Fernando,Mora, Liadys Korean Chemical Society 2010 대한화학회지 Vol.54 No.4

마약인 모르핀, 헤로인, 코데인, 펜타조신 그리고, 버프레노파인에 대하여 범밀도함수이론에 근거하여 계산 연구를 수행하였다. 약물특이 분자단과 치환기의 기하학적 파라미터는 B3LYP/6-31+G(d) 레벨로 계산하였고, 전자의 구조는B3LYP/6-311++G(d,p) 레벨로 같은 혼성 범함수를 사용하여 계산하였다. 원자의 전하분포는 Mulliken 개체 수 분석에 의하여 구하였다. 보고된 생물학적 활성, 계산된 분배 계수, 전자 및 기하학적 분석을 토대로 펜타조신과 버프레노파인을 새로 제시된 유사화합물에 대한 모델화합물로 선택하였으며, 이들 유사화합물에 대하여 연구한 뒤, 모델화합물과 비교하였다. 본 연구 결과는 약물특이 분자단의 기하학적 구조와 전자 구조가 다른 치환기의 존재 하에서도 변함없이 유지된다는 것을 보여주었다. 제시된 유사화합물들도 모델 분자의 특성을 갖고 있기 때문에, 이들 유사화합물들도 생물학적 활성을 나타낼 것 같다. Computational studies were carried out on the opiates morphine, heroin, codeine, pentazocine, and buprenorphine, under the density functional theory. The geometric parameters of the pharmacophore and substituents were evaluated at the B3LYP/6-31+G(d) level of theory. The electronic structure calculations were performed using the same hybrid functional at the B3LYP/6-311++G (d,p) level of theory. The atomic charges were obtained by Mulliken population analysis. Given the reported biological activity, calculated partition coefficients, and electronic and geometric analysis, pentazocine and buprenorphine were chosen as models for proposed analogues. These analogues were then studied and compared with the model molecules. The study reveals that the geometry and electronic structure of the pharmacophore remains consistent in the presence of different substituents. Because the proposed analogues preserve the studied properties of the model molecules, it is likely that these analogues display biological activity.

Quebec Serve and Protect Low Back Pain Study: What About Mental Quality of Life?

Douma, Nabiha Benyamina,Cote, Charles,Lacasse, Anais Occupational Safety and Health Research Institute 2019 Safety and health at work Vol.10 No.1

Background: As of now, the impact of low back pain (LBP) and its chronic state, chronic low back pain (CLBP), on mental health-related quality of life (HRQOL) has never been investigated among police officers. The present investigation aims at studying this relationship using a biopsychosocial model. Methods: Between May and October 2014, a Web-based cross-sectional study was conducted among Quebec police officers (Quebec, Canada). Mental HRQOL was measured using the role emotional (RE) and the mental health (MH) domains of the SF-12v2 Health Survey. The impact of CLBP on mental HRQOL (as opposed to acute/subacute LBP or no LBP) was studied with a multivariate linear regression model. Results: Of the 3,589 police officers who participated in the study, 1,013 (28.4%) reported CLBP. The mean age of respondents was $38.5{\pm}8.7years$, and 32.0% were females. The RE (44.1/100) and MH (49.0/100) mean scores of the CLBP group were comparable with the scores found in populations suffering from cancer or heart diseases. Compared to officers without LBP, the presence of CLBP was significantly associated with lower RE (${\beta}$: -0.068; p = 0.003) and MH (${\beta}$: -0.062; p = 0.002) scores. These relationships were not found in the acute/subacute LBP group. Conclusion: Our results underscore how frequent CLBP is among police officers and how burdensome it is. Considering the importance of good physical and mental health for this occupational population, police organizations should be aware of this issue and contribute to the efforts toward CLBP prevention and management in the workplace.