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Angel A,de Larrazabal,FPSCS,FACS,Corazon Collantes-Jose,FPSCS 대한미용의학회 2017 대한미용의학회지 Vol.1 No.2
Background: Minimally invasive surgery is already at the forefront in all surgical specialties, including cosmetic surgery. Hence, we have adapted and modified our technique to offer a short-scar facelift with minimal tissue dissection and manipulation to surgically rejuvenate the aging face. Objective: This study aimed to surgically address the aging face and neck by employing this modified short-scar rhytidectomy with minimal dissection, manipulation, and using the correct vector suited for Asian faces as an alternative and innovative surgical procedure. Methods: We performed this short-scar facelift by combining the malar fad pad suspension and lamellar low superficial musculoaponeurotic system (SMAS) excision Results: From 2015 to 2017, we have performed 51 facelift procedures with our modification, with 8 men and 43 women, with a mean age of 64.30 years (range, 50-78 years). Of the 51 patients, 29 patients (56.86%) had regular follow-ups. Three complications were noted. One developed post-operative hematoma. The other developed seroma formation. The third developed split thickness skin necrosis. Majority of our patients were satisfied with the results. Conclusion: This combined malar fat pad suspension and lamellar low SMAS excision technique is a simple, safe, and effective alternative procedure for facelift. Level of Evidence: V
헥터 수마노,Luis Ocampo,Graciela Tapia-Perez,Corazon de Jesus Mendoza,Lilia Gutierrez 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.5
Pharmacokinetic/pharmacodynamic (PK/PD) ratios of reference enrofloxacin (Enro-R) and enrofloxacin as HCl-2H2O (Enro-C), as well as Monte Carlo simulations based on composite MIC50 and MIC90 (MIC, minimum inhibitory concentration) vs. Leptospira spp., were carried out in dogs after their intramuscular (IM) or oral administration (10 mg/kg). Plasma determination of enrofloxacin was achieved by means of high-performance liquid chromatography. Maximum plasma concentration values after oral administration were 1.47 ± 0.19 mg/mL and 5.3 ± 0.84 mg/mL for Enro-R and Enro-C, respectively, and 1.6 ± 0.12 mg/mL and 7.6 ± 0.93 mg/mL, respectively, after IM administration. Areas under the plasma vs. time concentration curve in 24 h (AUC0–24) were 8.02 mg/mL/h and 36.2 mg/mL/h for Enro-Roral and Enro-Coral, respectively, and 8.55 ± 0.85 mg/mL/h and 56.4 ± 6.21 mg/mL/h after IM administration of Enro-R and Enro-C, respectively. The PK/PD ratios and Monte Carlo simulations obtained with Enro-C, not Enro-R, indicated that its IM administration to dogs will result in therapeutic concentrations appropriate for treating leptospirosis. This is the first time enrofloxacin has been recommended to treat this disease in dogs.
Zainul Amiruddin Zakaria,Nurul Husna Sodri,Halmy Hassan,Khairiyah Anuar,Fatimah Corazon Abdullah 셀메드 세포교정의약학회 2012 TANG Vol.2 No.4
The present study aimed to determine the possible mechanisms of the peripheral antinociception of the aqueous extracts of Dicranopteris linearis (AEDL), Melastoma malabathricum (AEMM) and Bauhinia purpurea (AEBP) leaves in mice. Briefly, the antinociceptive profile of each extract (300, 500, and 1000 mg/kg; subcutaneous (s.c.)), was established using the abdominal constriction test. A single dose (500 mg/kg) of each extract (s.c.) was pre-challenged for 10 min with various pain receptors’ antagonists or pain mediators’ blockers and 30 min later subjected to the antinociceptive assay to determine the possible mechanism(s) involved. Based on the results obtained, all extracts exerted significant (p < 0.05) antinociceptive activity with dose-dependent activity observed only with the AEMM. Furthermore, the antinociception of AEDL was attenuated by naloxone, atropine, yohimbine and theophylline; AEMM was reversed by yohimbine, theophylline, thioperamide, pindolol, reserpine, and 4-chloro-DL-phenylalanine methyl ester hydrochloride; and of AEBP was inhibited by naloxone, haloperidol, yohimbine and reserpine. In conclusion, the antinociceptive activity of those extracts possibly involved the activation of several pain receptors (i.e. opioids, muscarinic, 2-adrenergic and adenosine receptors, adenosine, H3-histaminergic and 5HT1A, dopaminergic receptors).
Atefeh Seyyedan,Farhana Yahya,Mohammad Fauzi Fahmi Kamarolzaman,Zarizal Suhaili,Mohd Nasir Mohd Desa,Hussain Mohd Khairi,Muhammad Nazrul Somchit,Corazon Abdullah Fatimah,Lay Kek Teh,Mohd Zaki Salleh,Z 셀메드 세포교정의약학회 2013 TANG Vol.3 No.3
Piper sarmentosum is a creeping herb belongs to the family of Piperaceae. It is locally known to the Malays as ‘Pokok kadok’ and can be found in different regions of South-East Asia including Malaysia. Ethnopharmacologically, various parts of the plant (e.g. leave, fruit and root) are widely used in Asian countries for centuries to treat different types of diseases and ailments such as hypertension, diabetes, joint aches, muscle pain, coughs, influenza, toothaches and rheumatism. Scientific findings also demonstrated different pharmacological actions of various parts of P. sarmentosum such as adulticidal, antitermite, antioxidant, antifungal, antituberclosis, antiplasmoid, antimalarial, hypoglycemia, antiinflammatory, antinoceptive, antipyretic, antibacterial, anticancer, antituberculosis, antiangiogenesis, antimicrobial, antifeedant and cytotoxic activities. Different types of phytochemical constituents have been successfully identified and isolated from various parts of P. sarmentosum. Therefore, the information related to the botany, ethnomedicinal uses, phytochemical constituents and pharmacological activities of P. sarmentosum were reviewed here.