Enhancement of cutaneous immune response to bacterial infection after low-level light therapy with 1072nm infrared light: A preliminary study

Celine Lee, S.Y.,Seong, I.W.,Kim, J.S.,Cheon, K.A.,Gu, S.H.,Kim, H.H.,Park, K.H. Elsevier Sequoia 2011 Journal of photochemistry and photobiology. B, Bio Vol.105 No.3

We investigated the photobiomodulation effects of 1072nm infrared light on the natural immune response involved in anti-bacterial and wound healing processes. Thirty mice infected with MRSA on the skin were divided into two groups. The experimental group was treated with 1072nm infrared light (irradiance: 20mW/cm<SUP>2</SUP>, fluence: 12J/cm<SUP>2</SUP> for 10min) at 2, 4, 8, 12, 24h, 3 and 5days after inoculation and the control group with sham light. Serial changes of the mRNA levels of TLR2, IL-1β, TNF-α, IL-6, iNOS, MCP-1, TGF-β, bFGF and VEGF were studied by real time RT-PCR and those of the expression level of VEGF, bFGF, TGF-β and NF-κB by immunohistochemistry. The mRNA levels of the cytokines involved in the early phase of anti-bacterial immune response (IL-1β, TNF-α, IL-6, MCP-1) increased significantly in the 1072nm group, peaking between 12 and 24h post-inoculation. These levels normalized after 3-5days. Immunohistochemistry revealed a notably stronger expression of VEGF in the 1072nm group from 8-h post-inoculation to 5-day post-inoculation. We concluded that 1072nm infrared light had a photobiomodulation effect which resulted in an enhanced biological immune response to the bacterial infection by MRSA and also increased the expression of VEGF to a significant level.

기획번역 : 도시의 인간화

( Celine Sachs Jeantet ),조은숙(역) 한국도시연구소 1996 도시와 빈곤 Vol.24 No.-

Photo-triggered Theranostic Nanoparticles in Cancer Therapy

Celine DG. Abueva 대한의학레이저학회 2021 MEDICAL LASERS Vol.10 No.1

In cancer therapy, it is often desirable to use precision medicine that involves treatments of high specificity. One such treatment is the use of photo-triggered theranostic nanoparticles. These nanoparticles make it possible to visualize and treat tumors specifically in a controlled manner with a single injection. Several novel and powerful photo-triggered theranostic nanoparticles have been developed. These range from small organic dyes, semiconducting and biopolymers, to inorganic nanomaterials such as iron-oxide or gold nanoparticles, carbon nanotubes, and upconversion nanoparticles. Using photo-triggered theranostic nanoparticles and localized irradiation, complete tumor ablation can be achieved without causing significant toxicity to normal tissue. Given the great advances and promising future of theranostic nanoparticles, this review highlights the progress that has been made in the past couple of years, the current challenges faced and offers a future perspective.

Japan-South Korea Security Cooperation: Sisyphus Getting Muscles?

( Celine Pajon ),( Remy Hemez ) 한국국방연구원 2018 The Korean Journal of Defense Analysis Vol.30 No.2

This article aims to assess the progress of the ROK-Japan security cooperation in recent years, both in the bilateral and trilateral framework involving the United States. It argues that the unprecedented progress in North Korea’s nuclear program, along with a constant U.S. persuasion, led to a certain political convergence to allow and accompany the security cooperation. This said, political mistrust, asymmetric expectations and diverging perspectives still persist, explaining why the cooperation is mainly taking place within the trilateral framework. Nevertheless, the latest set of dialogue, exchanges and joint exercises did build up confidence and highlighted the benefit of an expanded cooperation while pushing the two countries to seriously consider the concrete issues, conditions and implications of such cooperation. The paper concludes that the recent progress in the security cooperation is still fragile and dependent on external factors, even if it is pointing to a greater understanding.

Photobiomodulation Therapy in the Treatment of Salivary Dysfunction

Celine DG. Abueva 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.1

Photobiomodulation therapy, owing to its photobiological anti-inflam-matory and wound healing effects, has been suggested as a non-invasive, safe, and effective approach in treating salivary dysfunctions. Xerostomia or dry mouth and hyposalivation are challenging conditions, and patients suffer oral problems and a poor quality of life. Several studies have demonstrated the potential of photobiomodulation in reducing xerosto-mia and hyposalivation. However, there is a lack of synthesis of available evidence to establish whether it is an efficient, safe, and cost-effective method. In addition, the challenges include the lack of consensus on the optimal PBM dosage, as well as the variability of the findings in published studies.

Roles of Illness Attributions and Cultural Views of Cancer in Determining Participation in Cancer-Smart Lifestyle among Chinese and Western Youth in Australia

Wei, Celine,Wilson, Carlene,Knott, Vikki Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: The study investigated the influence of culturally-based health beliefs on engagement in healthy lifestyle behaviour. Specifically, the study compared levels of engagement between Western and Chinese youth in Australia and assessed the extent to which culture-specific attributions about the causes of illness, and health beliefs, predict engagement in healthy lifestyle behaviour. Materials and Methods: Ninety-four Western and 95 Chinese (N=189; Mean Age=20.8 years, SD=3 years) young adults completed an online questionnaire. Predictor variables were cultural health beliefs measured by the Chinese Cultural Views on Health and Illness scale (CCVH, Liang et al., 2008), and illness attributions beliefs measured by the Cause of Illness Questionnaire (CIQ, Armstrong and Swartzman, 1999). Outcomes variables were levels of engagement in healthy lifestyle behaviour. Results: Results indicated that Chinese participants have a significantly lower exercising rate and healthy dietary habits compared to the Western sample. Moreover, Chinese participants were found to believe more strongly than Westerners that cancer was associated with factors measured by the Traditional-Chinese-Model (TCM). Finally, the observed relationship between cultural health beliefs and physical inactivity was mediated by attributions of illness, in particular to the supernatural subscale, with the Sobel Test showing a significant mediation (z=-2.63, p=0.004). Conclusions: Mainstream approaches to encourage healthy lifestyles are unlikely to be effective when educating Chinese youth. Instead, health promotion programs should attempt to address the illness attribution beliefs and educate Chinese youth about the role of diet and exercise in prevention of diseases such as cancer.

Photoresponsive Hydrogels as Drug Delivery Systems

ABUEVA CELINE,Phil-Sang Chung,류현석,So-Young Park,우승훈 대한의학레이저학회 2020 MEDICAL LASERS Vol.9 No.1

Hydrogels have been developed and used in tissue engineering and regenerative medicine to deliver therapeutics to injured or diseased tissue because of their versatility and properties that can be tailored to match the natural extracellular matrix. Hydrogels can be made with a variety of physical and chemical properties combined with light responsiveness ideal for applications in different fields of medicine that require the spatiotemporal control of therapeutics. Light, as a stimulus, is relatively inexpensive, contact-free, noninvasive with high spatial resolution and temporal control, convenient and easy to use, and allows deep tissue penetration that is relatively harmless. Photoresponsive hydrogels are ideal candidates for on-demand drug delivery systems that are capable of sustained and controlled drug release, minimizing the side effects, and ensuring the activity and efficient delivery of drugs to the target tissue.

A Proposed System Architecture of IoT-Assisted Educational Tools for Hybrid Learning

Thian Celine Iskandar 국제과학영재학회 2022 APEC Youth Scientist Journal Vol.14 No.1

In recent years, the education sector has been one of the hardest hit by the COVID-19 pandemic, with schools struggling to find ways to stay open. A lot of educational institutions choose to implement hybrid learning systems, which is the combination of face-to-face and online learning using a variety of e-learning tools. Some educational tools are required to support the interactions between students, lecturers, and administrators so that the teaching and learning process runs smoothly. As an emerging e-learning system, there are some challenges that arise related to the tools. Also, constant technical issues faced by both teachers and students on these e-learning tools often require technical support to rectify, causing frequent disruptions in the learning flow. In this study, we analyzed the limitations and challenges of the existing e-learning tools that support the hybrid learning system at Sekolah Menengah Atas Kristen Penabur. This study proposes a solution for solving the present issues and limitations of the current e-learning tools. We propose an efficient architecture that supports efficient and reliable e-learning tools for students, lecturers, and administrators at SMAK Penabur. According to the findings, the proposed architecture has a significant impact on the learning and teaching development of hybrid learning environments. It also provides an efficient and reliable means of using e-learning tools in a hybrid learning environment.

Phosphonate-chitosan functionalization of a multi-channel hydroxyapatite scaffold for interfacial implant-bone tissue integration

Abueva, Celine D. G.,Jang, Dong-Woo,Padalhin, Andrew,Lee, Byong-Taek Royal Society of Chemistry 2017 Journal of Materials Chemistry B Vol. No.

<P>Nonunion associated with long bone defects continues to be highly researched both experimentally and clinically. A porous hydroxyapatite (HAp) scaffold has been recognized as a bone repair and substitute material clinically, but its use in segmental bone defects has been limited by poor integration and stability, as a consequence of scaffold strength unmatched with the native bone. Herein, we designed a multi-channel HAp-based scaffold for application in segmental bone defects, with a specific geometry and design. It possesses the required porosity for bone tissue regeneration with sufficient mechanical properties. We also developed a surface functionalization/modification method with the goal of early scaffold integration and stability. Initial functionalization with poly(vinyl phosphonic acid), PVPA, allowed simple attachment of a chitosan polymeric layer. The modification improved the biocompatibility of the scaffold and attachment of rat bone marrow-derived mesenchymal stem cells (rBMSC) <I>in vitro</I>. The modification also served as a buffer between the implant scaffold and bone tissue. Significant improvement in the integration behavior with better interlocking of the scaffold to bone tissue was observed for the modified scaffolds implanted in rabbit tibiae. The modified HAp scaffolds exhibited early interfacial implant-bone tissue integration with enhanced new bone formation and high potential for use in segmental bone defects.</P>

What Matters for Innovation and Leadership in Women eBusiness?

Shen, Celine Yi;Ge, Jianqiao Asian Pacific Women's Information Network Center t 2006 APWIN Vol.8 No.-