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- 저자 : Akansha (검색결과 4 건)
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Akansha Mehta,Manu Sharma,Ashish Kumar,Soumen Basu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.9
Synthesis of gold nanoparticles dispersed uniformly on mesoporous silica (mAu/SiO2) by homogeneous deposition–precipitation (HDP) method is used as an effective catalyst for reduction of 4- nitrophenol to 4-aminophenol. Silica provides support and surface area to increase the catalytic activity of gold. X-ray photon spectroscopy revealed binding energy of Au 4f7/2 (~84.0 eV) and Au 4f5/2 (~87.7 eV) which support the formation of Au0 on SiO2 surface. Au/SiO2 showed Langmuir type-IV isotherms which are the characteristic features of mesoporous materials furthermore, pore size decreases with incorporation of Au NP's on SiO2 surface. The enhancement is due to the strong interaction of Au0 with silica support. The catalytic conversion was studied by UV-Visible spectroscopy and high performance liquid chromatography (HPLC) quantification method, which shows conversion of nitro group into amino group. In addition, the catalyst was easily separated and reused. The reusability of the catalyst exhibited better reduction of the 4-nitrophenol to 4- aminophenol even after 10 consecutive cycles. In comparison to trisodium citrate capped pure gold nanoparticles mAu/SiO2 catalysts showed very good catalytic activity toward nitrophenol reduction. Here we conclude that embedment of metal catalysts like Au into high surface area support like silica is a positive step toward development of novel heterogeneous catalysts.
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Antidiabetic activity of an Ayurvedic Formulation Chaturmukha Rasa: A mechanism based study
Akansha Sharma,Raj K Tiwari,Vikas Sharma,Ravindra K Pandey,Shiv Shnakar Shukla 대한약침학회 2019 Journal of pharmacopuncture Vol.22 No.2
Objectives: The objective of this study was to evaluate antidiabetic activity of Chaturmukha rasa based on streptozotocin induced diabetes model, alpha amylase inhibitory activity, alpha Glucosidase inhibitory activity and inhibition of sucrase. Methods: Chaturmukha rasa was prepared as per Ayurvedic formulary. Antidiabetic activity was measured in experimentally streptozotocin induced rats. The dose was taken as 45 mg/kg, i.p. The antidiabetic activity of Chaturmukha rasa was compared Triphala Kwatha, a marketed formulation. Further In vitro ά- Amylase Inhibitory Assay, In vitro salivary amylase Inhibitory Assay, In vitro α-Glucosidase Inhibitory Assay and In vitro Sucrase Inhibitory Assay was performed with respect to Chaturmukha rasa. The IC50 value was calculated for all the above activity. Results: Streptozotocin with Acarbose showed significant decrease in blood glucose level whereas streptozo-tocin with Triphala kwatha showed more decrease in blood glucose level than Streptozotocin with Acarbose. The combination of Streptozotocin + Triphala kwatha + Chaturmukha rasa showed a significant decrease in blood glucose level on 21st day. In vitro ά- Amylase Inhibitory Assay the Chaturmukha rasa showed IC50 value 495.94 μl when compared with Acarbose 427.33 μl, respectively. In the α-Glucosidase Inhibitory Assay Chaturmukha rasa showed IC50 value 70.93 μl when compared with Acarbose 102.28 μl, respectively. In vitro Sucrase Inhibitory Assay Chaturmukha rasa showed IC50 value 415.4 μl when compared with Acarbose 371.43 μl, respectively. Conclusion: This study supports that Chaturmukha rasa may inhibit diabetes by inhibition of salivary amylase or alpha Glucosidase or sucrase. This may be the mechanism by which Chaturmukha rasa inhibits diabetes. Further this study supports the usage of Chaturmukha rasa for the management of diabetes.
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Wormhole Attack in Mobile Ad-hoc Network : A Survey
Akansha Shrivastava,Rajni Dubey 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.7
Security is the one of the major issue that exists in Mobile Ad hoc network. Mobile Ad hoc network is infrastructure less network so it is vulnerable to several security attacks that are on different layers. Wormhole attack is one of the serious routing attack on network layer. This paper focuses on the wormhole attack, its classification and the modes by which they are launched. This paper summarizes various detection techniques proposed for wormhole attack and also present the effect of wormhole attack on various performance parameters.
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Antidiabetic Activity of an Ayurvedic Formulation Chaturmukha Rasa: A Mechanism Based Study
Sharma, Akansha,Tiwari, Raj K,Sharma, Vikas,Pandey, Ravindra K,Shukla, Shiv Shnakar KOREAN PHARMACOPUNCTURE INSTITUTE 2019 Journal of pharmacopuncture Vol.22 No.2
Objectives: The objective of this study was to evaluate antidiabetic activity of Chaturmukha rasa based on streptozotocin induced diabetes model, alpha amylase inhibitory activity, alpha Glucosidase inhibitory activity and inhibition of sucrase. Methods: Chaturmukha rasa was prepared as per Ayurvedic formulary. Antidiabetic activity was measured in experimentally streptozotocin induced rats. The dose was taken as 45 mg/kg, i.p. The antidiabetic activity of Chaturmukha rasa was compared Triphala Kwatha, a marketed formulation. Further In vitro $\acute{\alpha}$- Amylase Inhibitory Assay, In vitro salivary amylase Inhibitory Assay, In vitro ${\alpha}-Glucosidase$ Inhibitory Assay and In vitro Sucrase Inhibitory Assay was performed with respect to Chaturmukha rasa. The IC50 value was calculated for all the above activity. Results: Streptozotocin with Acarbose showed significant decrease in blood glucose level whereas streptozotocin with Triphala kwatha showed more decrease in blood glucose level than Streptozotocin with Acarbose. The combination of Streptozotocin + Triphala kwatha + Chaturmukha rasa showed a significant decrease in blood glucose level on 21st day. In vitro $\acute{\alpha}$- Amylase Inhibitory Assay the Chaturmukha rasa showed IC50 value $495.94{\mu}l$ when compared with Acarbose $427.33{\mu}l$, respectively. In the ${\alpha}-Glucosidase$ Inhibitory Assay Chaturmukha rasa showed IC50 value $70.93{\mu}l$ when compared with Acarbose $102.28{\mu}l$, respectively. In vitro Sucrase Inhibitory Assay Chaturmukha rasa showed IC50 value $415.4{\mu}l$ when compared with Acarbose $371.43{\mu}l$, respectively. Conclusion: This study supports that Chaturmukha rasa may inhibit diabetes by inhibition of salivary amylase or alpha Glucosidase or sucrase. This may be the mechanism by which Chaturmukha rasa inhibits diabetes. Further this study supports the usage of Chaturmukha rasa for the management of diabetes.
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