http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
OVA로 유도된 생쥐 모델에서 EGCG의 천식 예방 효과
박성남,이찬우,이창민,정만홍,황순철,박영민 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
Epigallocatechin-3-gallate (EGCG), a major form of tea epicatechin, has a variety of biological activities. It has recently been studied intensively as an antiallergic and anti-inflammatory agent. Thus we elucidated the anti-allergic effect of EGCG in the ovalbumin (OVA)-induced asthma model mice by examining the expression of matrix metalloproteinase (MMP)-9. Also airway reactivity to methacholine challenge and reactive oxygen species (ROS) generation in BAL fluid. mesured by the expression of iNOS mRNA in lung tissue and tumor necrosis factor (TNF) in BAL fluids. The OVA challenged mice showed allergic airway reactions, such as inflammatory chemokine (CCL5,CXCL10) in the airway and lung tissues. However mice administrated with EGCG had significantly reduced CCL5 and MMP-9 expression in lung tissues as well as TNF-α and IL-5 production in BAL fluid. these results suggest that EGCG regulate