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폐경여성의 난소에서 발생한 양성 및 악성종양에 관한 임상적 고찰
최승도 ( Seung Do Choi ),배동한 ( Dong Han Bae ),선우재근 ( Jae Gun Sunwoo ),정성윤 ( Seong Yun Jeong ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objective :This study was performed to compare the clinical characteristics of benign and malignant tumor in postmenopausal woman. Methods :We reviewed the chart of 91 postmenopausal women over 50 years of age, operated and confirmed by postoperative histopathologic study at Department of Obstetrics and Gynecology, Soonchunhyang Chunan Hospital, from January 1st 1995 to December 31th 1998. Results . Benign ovarian tumor was found in 85.7% (78 cases) and malignant ovarian tumor was found in 14.3% (13 cases). Age distribution of malignant ovarian tumors showed the highest frequency in the age group 61-65 years compared to benign ovarian tumor. In the larger than 10 cm in tumor size, there were 7 benign (58.3%) and 5 malignant (41.7%) lesion. There was no evidence of malignant tumor according to the parity. In malignant lesion, stage I was seen in 15.4%, stage II in 30.7%, stage III in 7.7%, stage IV in 23.0% and unexplored in 23.0%. Tumor marker of CA 125 in malignant lesion was increased in 69.2%. As the subjective symptoms of benign lesions, no symptom was noticed in 38.4%, but in malignant lesions, lower abdominal pain was noticed in 38.4fo as the most common. Bilaterality in benign lesions was noted in 29.4% and the same in malignant lesions was 15.3%. Conclusions :Considering the above results, as the tumor size increases, the risk of malignancy increases.
최승도 ( Seung Do Choi ) 대한폐경학회 2012 대한폐경학회지 Vol.18 No.2
Ezrin은 세포골격 연결 단백질로 세포의 수축요소와 막투과단백질 사이를 연결하여 세포 형태, 운동성, 세포와 세포사이 상호작용을 조절한다. 이러한 기전을 통해 ezrin은 암의 진행과 원발성 전이에 중요한 역할을 할 것이라고 생각한다. 이에 더해, 유방암, 대장암, 골육종, 전립선암과 같은 많은 암종에서 높은 농도의 ezrin 발현이 관찰된다. 고농도의 ezrin 발현을 보이는 부인암세포는 ezrin이 저농도로 발현되는 경우보다 좀 더 침습적인 경향을 보인다. 또 ezrin이 높은 농도로 발현되는 것은 진행된 조직학적 등급과 불량한 예후와 관련있다. 최근 몇몇 보고에 따르면 진행된 병기의 암세포와 전이성 부인암 세포에서 ezrin 발현이 증가하고 막부위로의 이동이 관찰되었다. 그러므로, 가까운 미래에 ezrin 농도와 세포내 위치는 부인암 전이의 중요한 인자로 작용할 것이다. Ezrin, a membrane cytoskeleton linking protein, is a member of ezrin/radixin/moesin (ERM) that regulates cell shape, motility and cell to cell interaction via linking the contractile elements of the cell to transmembrane proteins. Ezrin, through this mechanism, has been thought to play an important role in cancer progression and distant metastasis. In addition, high levels of ezrin expression have been noted in many cancers, such as breast, colon, osteosarcoma, and prostate cancer. Gynecologic cancer cells, with high levels of ezrin expression, have more invasive potential than that of the lower levels of ezrin expressed cancer cells. High levels of ezrin expression are also related to the advanced histological grade and poor outcome. Recently, several reports have also demonstrated that ezrin expression is enhanced and almost localized at the membranous portion in high stage tumor cells and metastatic gynecologic cancer cells. Therefore, in the near future, ezrin levels and its cellular location might serve as essential markers for the metastasis of gynecologic cancers.
폐경 후 여성에서 저용량 성장 호르몬 요법이 골밀도, 인슐린양 성장인자, 악력 및 체지방과 혈중 지질 성분에 미치는 영향에 대한 연구
최홍준 ( Hong Jun Choi ),김윤숙 ( Yoon Sook Kim ),전섭 ( Seob Jeon ),김종수 ( Jong Soo Kim ),최승도 ( Seung Do Choi ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3
목적: 폐경 후 여성에서 저용량 성장 호르몬 요법이 골밀도에 미치는 영향에 대해 알아보고자 본 연구를 시행하였다. 연구 방법: 2003년 10월에서 2004년 3월까지 6개월 간 순천향대학교 천안병원 산부인과 외래에서 저용량 성장 호르몬 치료를 받은 폐경 후 여성 9명을 대상으로 생화학적 골지표와 골밀도 변화를 측정하여 그 변화를 비교 분석하였다. 결과: 다음과 같은 결과를 얻었다. 1. 환자의 평균 연령은 62.2±2.7세 였다. 2. 오스테오칼신은 Objective: To determine the effect of low-dose growth hormone (GH) replacement therapy on bone mineral density at the lumbar spine and femur, IGF-1, hand grip, body fat and serum lipid compositions in postmenopausal women. Methods: A total of 9 postmenopa
요실금 환자의 경폐쇄공 질테이프수술 후 반복되는 질 미란의 피부판 이식을 이용한 치료
홍정희 ( Jung Hee Hong ),최승도 ( Seung Do Choi ),김윤숙 ( Yun Sook Kim ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ),안형식 ( Hyung Sik Ahn ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.3
Transobturator tape (TOT) as one of midurethral slings is increasingly popular for the surgical treatment of stress urinary incontinence because of low complication rate and short operating time. Vaginal erosion after TOT is generally observed in 0.7%-1.3% of all cases. For preventing complications like vaginal erosion or infection after TOT, subtotal or total excision of mesh materials and use of broad-spectrum antibiotics are recommended. We report our experience with a case of treatment using skin fl ap and foreign body removal of recurrent mesh erosion in TOT.
복강경하 일측 난관절제술 후 발생한 복강 내 착상 융모조직의 치료 예
문성택 ( Seong Taek Mun ),김윤숙 ( Yun Sook Kim ),전섭 ( Seob Jeon ),최승도 ( Seung Do Choi ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.4
The incidence of ectopic pregnancy has increased considerably a decade. And treatment has changed from salpingectomy by laparotomy to conservative laparoscopic surgery or medical treatment. This procedure has many advantages, but there are also disadvantages with the conservative approach and several studies have reported a higher incidence of residual trophoblastic tissue remaining in the tube after treatment. Postoperative follow up of human chorionic gonadotropin (hCG) levels and ultrasonography are needed. This report describes a rare case of persistent trophoblastic implants to the ovary and peritoneum 40 days after laparoscopic salpingectomy. Treatment consisted of laparoscopic excision with biopsy forceps and bipolar, followed by medical treatments. So we report with a brief review of literatures.
문성택 ( Seong Taek Mun ),김윤숙 ( Yun Sook Kim ),전섭 ( Seob Jeon ),최승도 ( Seung Do Choi ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.9
Uterine prolapse is extremely rare during pregnancy. However in some cases significant complications such as urinary tract infection, voiding difficulty, abortion, and preterm labor may develop. Conservative management consisted of bed rest and use of a pessary. An elective cesarean section near term is the safest mode of delivery in cases where the cervix is edematous and elongated. We present a case of a patient developing uterine prolapse at 12 weeks of gestation, treated with bed rest and use of a pessary. A repeat cesarean section was performed at 38 weeks of gestation and report with a brief review of literatures.
김윤숙 ( Yoon Sook Kim ),전섭 ( Seob Jeon ),김종수 ( Jong Su Kim ),최승도 ( Seung Do Choi ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ),양승하 ( Seung Ha Yang ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.8
Angiomyoma is a rare, benign, mesenchymal tumor occurring mainly in the female genital tract and higher incidence in the fourth to sixth decades of life. It is originated from smooth muscle cells and contains thick-walled vessels. The most satisfactory treatment is complete excision. We experienced a case of the broad ligamentary angiomyoma that was treated by complete excision with a brief review of literature.
임신중기 모체 혈청 알파 태아 단백 , free β - hCG 를 이용한 산전선별검사 위양성과 주산기 예후에 관한 연구
채명관(Myung Kean Chae),이해혁(Hae Hyeog Lee),최승도(Seung Do Choi),이항재(Hang Jae Lee),이정재(Jeong Jae Lee),남계현(Kae Hyun Nam),이임순(Im Soon Lee),이권해(Kwon Hae Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
N/A Objective: To determne whether abnormal results of doble saeening tests for Down syndrome with MSAFP and free B-hCG are associated with adverse pregnancy outcome. Methods: Between October 1994 and September 1997, 205 among 1731 who were screened had increased risk for Down screening program of CIS biointernational, Fetuses with Chromosomal abnormality or congenital anomalies and less than 35 years of maternal age were excluded from this study. Down syndrome screening test was performed between 14-22 weeks of gestation. Results: Of 1731 women, 205 (13.4%) had increased Down syndrome risk. The pregnancy outcome of women with increased Down syndrome risk were compared with those of women without such risk There were no significant difference in the incidence of preterm labor (6[2.9%] vs 112[7.3%)), premature rupture of the membranes (2[0.9%] vs 56[3.6%]), pregnancy induced hypertension (2[0.9%] vs 36[2.3%]), abruptio placentae (0[0%] vs 2[0.1%]), low birth weight (2[0.9%] vs 21[1.3%]), oligohydramnios (4[1.9%] vs 10[0.6%]), intrauterine fetal death (0[0%] vs 2[0.1%]). Conclusion: False positive results of Down syndrome screening test in the 2nd trimester do not appear to be associated with adverse pregnancy outcome. But there are statistically significant increases of adverse pregnancy outcome in wemen with elevation of MSAFP or elevation of free B-hCG.
임신과 합병된 자궁경부 상피내암과 침윤성 자궁경부암의 임상적 고찰
김종수 ( Jong Soo Kim ),김윤숙 ( Yoon Sook Kim ),최승도 ( Seung Do Choi ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
목적 : 임신과 합병된 자궁경부암은 그 빈도가 매우 낮아 1/2,200의 빈도로 보고되고 있으며 실제적으로 산부인과 의사가 경험하는 예는 매우 적으나 최근 13년 동안의 임신과 동반된 자궁경부 상피내암 및 자궁경부암의 임상양상, 병리조직학적 종류, DNA chip을 이용한 HPV아형 및 분만 후 5년 생존률에 대해 알아보고 향후 임신과 합병된 자궁경부암의 처치에 기여하고자 하였다. 연구 방법 : 1990년 1월부터 2002년 12월까지 13년간 순천향대 Objective : Cervical cancer is the most common malignancy of the female genital tract in Korea. Recognized prognostic factors include FIGO stage, histologic grade, depth on invasion, primary cancer screening and age. However, prognosis of pregnant woman w
급성 복통을 호소하는 사춘기 여성에서 발견된 낭종성 자궁샘근증 1예
유애리 ( Ae Li Ryu ),전섭 ( Seob Jeon ),김윤숙 ( Yoon Sook Kim ),최승도 ( Seung Do Choi ),선우재근 ( Jae Gun Sunwoo ),배동한 ( Dong Han Bae ),양승하 ( Seung Ha Yang ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.4
자궁샘근증은 4~50대 여성에서 흔한 질환으로 낭종성 자궁샘근증의 발생은 드물며 더구나 청소년기에 발생하는 경우는 매우 드문 것으로 알려져 있다. 최근 저자들은 평소 월경통이 심했던 15세 청소년 여성에서 급성 하복부 통증을 동반한 낭종성 자궁샘근증 1예를 경험하였다. 복강경수술을 통해 자궁 내 낭종성 병변의 조직생검하였고 수술 후 복통이 곧바로 호전되었다. 병리조직학적 검사 결과상 낭종성 자궁샘근증으로 진단되어 간단한 문헌고찰과 함께 보고하는 바이다. Cystic adenomyosis is a rare form of adenomyosis of the uterine myometrium that has been described in older adults. This condition has not frequently been reported in the adolescent girl. The adenomyotic cyst was located within the myometrium of a 15-year