http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
기관지 천식 환자에서 혈청 IL - 6 , ICAM - 1 , RANTES 농도 측정의 임상적 의의
최재선(Jae Sun Choi),이병훈(Byung Hoon Lee),안창혁(Chang Hyuk Ahn),유지훈(Ji Hoon Yoo),나문준(Moon Jun Na),김재열(Jae Yeol Kim),박인원(In Won Park),최병휘(Byung Whui Choi),허성호(Sung Ho Hue) 대한내과학회 1998 대한내과학회지 Vol.55 No.5
N/A Bronchial asthma is a chronic airway inflammation disorder involving lymphocyte activation and various cytokines secretion by lymphocyte. The inflammatory response results from a complex network of interactions between inflammatory cells (mast cells, eosinophils, macrophages) and resident cells belonging to the lung structure itself like EC, fibroblasts, or bronchial epithelial cells. IL-6 which is known to up-regulate the endothelial cell expression of adhesion molecules participating in the development of the inflammatory reaction in bronchial asthma is produced by alveolar macrophage. ICAM-1 is produced by bronchial epithelial cell and expression by endothelial cell, which is known to enhance of the influx of various cells, RANTES which is known to a potent chemoattractant for eosinophils, lymphocytes, and monocytes, a member of the CC chemokine family, is expressed by bronchial epithelial cell. To evaluate whether markers of lymphocyte activation are useful markers of disease activity in bronchial asthma, we measured slL-6, sICAM- 1, sRANTES in 42 patients with mild to moderate bronchial asthma and in 26 normal controls and con the result with other disease activity markers in asthma(pulmonary function, blood eosinophil counts). The mean level of sIL-6 was higher than that of normal control and correlated significantly with sICAM-1, FEV1% to predicted value. The mean level of sICAM-1 was higher than that of normal control and correlated significantly with FEV1%, FEV1% to predicted value. The mean level of sRANTES showed the tendency to be higher than that of normal control, but not significant statistically, and did not correlated with sIL-6, sICAM-1, FEV1%, FEV1% to predicted value, blood eosinophil counts. It appeared that sIL-6 and sICAM-1 could be a disease marker in bronchial asthma. But, clinical application of the measurement of these markers needs to be studied further.
기관지천식 환자의 혈중 eosinophil cationic protein 치와 기관지과민성과의 관계
유지훈,최재선,안창혁,이병훈,나문준,김재열,박인원,최병휘,허성호 ( Ji Hoon Yoo,Jae Sun Choi,Chang Hyuk Ahn,Byung Hoon Lee,Moon Jun Na,Jae Yul Kim,In Won Park,Byung Whui Choi,Sung Ho Hue ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Background: Serum eosinophil cationic protein(ECP) level has been proposed as a indirect marker of eosinophilic inflammation of the airway in bronchial asthma. Objective'. To evaluate serum ECP against indirect clinical markers of disease, we compared bronchial obstruction, bronchial hyperresponsiveness and peripheral blood eosinophil counts, total IgE with serum ECP levels in patients with bronchial asthma and normal controls. Method: Fourty-two patients with bronchial asthma and twenty-six normal controls were enrolled. Measurement were made by spirometry, inhalation challenge with methacholine, peripheral blood eosinophil counts, total IgE and FEIA(fluoroenzymatic immunoassay) of serum ECP Result. Serum ECP levels were significantly higher in asthmatic patients than normal controls(p<0.0,5). Serum ECP levels were correlated with peripheral blood eosinophil counts(p<0.01, r=0.544) and bronchial hyperresponsiveness(PC,)(p<0.01, r=-0.456) in patients with bronchial asthma. Serum ECP levels were correlated with degree of bronchial obstruction(FEV, % to predicted value, FEV1/FVC%) in total subjects, but not in asthmatic patients. Conchcsion.' Serum ECP level may be used as indicator of disease activity in bronchial asthma and be helpful in differentiation between normal person and asthmatic patients on simple serological method. Further studies on the changes of serum ECP levels according to disease course and therapeutic responses are needed.
전태진(Tae Jin Chun),김명남(Myeung Nam Kim),최병휘(Byoung Whui Choi),송계용(Kye Yong Song),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6
Leser-Trelat sign is characterized by the sudden appearance and rapid increase in number and size of seborrheic keratoses associated with an internal malignancy. A 78-year-old woman showed multiple pea to bean sized dark brownish papules and plsques on the trunk. Skin lesions had appeared suddenly since 5 months ago and then rapidly increased in number and size. The histopathologic exsmination of the skin lesions revealed seborrheic keratoses. The chest roentgenogram revealed the mass shadow on the right hilar region and transbronchial lung biopsy revealed small cell carcinoma.
결핵성 흉막염에서 프레드니솔론의 치료효과 -흉막유착 발생에 대한 전향적 연구-
이병훈 ( Byoung Hoon Lee ),지현석 ( Hyun Suk Jee ),최재철 ( Jae Chul Choi ),박용범 ( Yong Bum Park ),안창혁 ( Chang Hyeok An ),김재열 ( Jae Yeol Kim ),박인원 ( In Won Park ),최병휘 ( Byung Whui Choi ),허성호 ( Sung Ho Hue ) 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.46 No.4
원저 : 만성 폐쇄성 폐질환에서 급성 호흡부전 발생시 Simplifed Acute Physiology Score에 따른 단기예후의 평가
이상표 ( Sang Pyo Lee ),성윤업 ( Yun Up Sung ),김상훈 ( Sang Hoon Kim ),김봉식 ( Bong Sik Kim ),김영준 ( Young Jun Kim ),박인원 ( In Won Park ),최병휘 ( Byung Whui Choi ),허성호 ( Sung Ho Hue ) 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.5
악성 , 결핵성 및 비특이성 흉막염 환자의 임상적 특성
김봉식(Bong Sik Kim),김상훈(Sang Hoon Kim),성윤업(Yun Up Sung),이상표(Sang Pyo Lee),박인원(In Won Park),최병휘(Byung Whui Choi),허성호(Sung Ho Hue),서승천(Seung Chun Seo) 대한내과학회 1995 대한내과학회지 Vol.48 No.1
N/A Objectives: The role of pleural biopsy in the evaluation of unexplained exudative pleural effusion has been well established. Although repeat pleural biopsy will increase the diagnostic yield in patients ultimately proven to have malignant or tuberculous pleuritis, it will increase the expense and morbidity of patients with nonspecific pleuritis. The identification of patients who should undergo additional diagnostic procedures is a difficult but important clinical problem. The purpose of this study was to determine if patients with nonspecific pleuritis could be distinguished from those with malignant or tuberculous pleuritis by clinical criteria. Methods: The medical records and chest roentgenograms of 93 patients who had pleural tapping and pleural biopsy performed during the five-year period from January 1986 to December 1990 at the department of Internal Medicine, Chung-ang University Hospital were reviewed. Results: The five clinical criteria, ie, fever, weight loss, pleurtitic chest pain, above moderate amount of pleural effusion, lymphocytosis of greater than 90 percent in pleural fluid, were observed significantly more often in the patients who were diagnosed to have either malignant or tuberculous pleuritis. The positive predictive value of the criteria, ie, the probability of the patient having tuberculous or malignant pleural disease, was 89 percent when one criterion was present and increased to 95 percent if two criteria were present. Conclusions: Based on our observations, we recommend the following diagnostic approach to the evaluation of an unexplained exudative pleural effusion. If the initial pleural biopsy reveals nonspecific pleuritis only in a patient without any of the above five criteria, further pleural biopsies are not needed, and the patient is followed up clinically. When two or more criteria are present, an aggressive diagnostic approach including repeat pleural biopsy is recommended.
기관지 천식환자에서 단기간 Prednisolone 경규투여후 나타난 기관지 과반응성 및 면역학적 지표의 변화
나문준(Moon Jun Na),이선우(Sun Woo Lee),신인철(In Cheol Shin),김영준(Young Jun Kim),박인원(In Won Park),최병휘(Byung Whui Choi),허성호(Sung Ho Hue) 대한내과학회 1992 대한내과학회지 Vol.43 No.2
N/A Recent studies have suggested that inflammation may play an important role in the characteristic bronchial hyperresponsivenees (BHR) and symptoms of bronchial asthma. The corticosteroid is widely used in bronchial asthmatics with antiinflammatory action, and improves the late response or bronchial hyperreactivity by the effect on the airway smooth muscle. Also, corticosteroid alters the immunologic properties by the mechanism which effects on the blood cells and their chemical mediators. In order to assess the effect of oral short-term prednisolone therapy on BHR in mild bronchial asthmatics, we measured nonspecific-BHR with methacholine bronchial provocation test [Meth-PC20 (mg/ml)], including IgE and eosinopohil count in peripheral blood in 2S bronchial asthmatic patients before and after treatment. Thery were divided into two groups; the control group (n=14) was treated with ordinary bronchodilator and antihistamine, and the steroid group (n=14) was treated with above regimen plus oral prednisolone (total 12wks; 30-40 mg/day for 1-2wks and tapering for 10-11wks). The results were as follows 1) Baseline FEV1 demonstrated no significant difference in both groups as 2340.00±500.56ml, 2296.43±514.29ml in control group, and 2387.14±683.48ml, 2474.29±660.74ml in steroid group before and after treatment. 2) Meth-PC20 was 8.92×/÷0.37 mg/ml before treatment and 12.29×/÷0.47 mg/ml after treatment in control group, which was not significantly changed. But after steroid therapy, Meth-PC showed significant change as 7.81 0.49 mg/ml vs 18.11×/÷0.51 mg/ml (p<0.05). 3) Peripheral eosinophil count was 272.25×/÷0.39/mm' before treatment and 254.38×/÷0.34/mm' after treatment in control group (p>0,05). In steroid group, it was 485. 83×/÷0.23/mm before treatment and 300.25×/÷0,40/mm after treatment (p0.05). 4) Total serum IgE measured as 147.38×/÷0.54 U/ml before treatment and 88.25×/÷0.43 U/ml after treatment in control group (p>0. 05). In steroid group, it was 563. 50×/÷0.64 U/ml before treatment and 302.92×/÷0.58U/ml after treatment (p<0.05). In conclusion, the oral corticosteroid therapy may reduce BHR in bronchial asthmatics with decrement of recruitment of activation of inflammatory cell, and inhibition of IgE production by the antiinflammatory effects.