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항암성 천연물 및 그 유사체(X) L1210 및 S-180에 대한 하늘타리의 항암성
이유희(You Hui Lee),강석균(Suck Kyun Kang),안병준(Byung Zoon Ahn) 대한약학회 1986 약학회지 Vol.30 No.4
A strongly cytotoxic fraction (Fc-2, ED50=0.0003mcg/ml) against L1210 cell was obtained from the root, seed and fruit of Trichosanthes kirilowii. Administration of Fc-2 prolonged the life span of the BDF1 mice bearing L1210 and the ICR mice bearing S-180 by 135% and 130%, respectively. The Fc-2 affected L1210 cells were enlarged in their diameters two or three times in comparison with the untreated ones. When 20mg/kg of Fc-2 was administered, intraperitoneally, all the mice were killed.
박유희,이은남,Park, You-Hui,Lee, Eun-Nam 한국재활간호학회 2005 재활간호학회지 Vol.8 No.2
Purpose: The purpose of this study is to understand the level of fatigue and daily living activities and to confirm their relationship in patients with chronic liver disease. Method: The sample consisted of 182 patients with chronic liver disease with a mean age of 42.4 years, who visited the D University Hospital and a S clinic from February, 2004 to March in 2004. Data were collected by a self reporting questionnaire on the selected variables such as fatigue and daily life activities. Collected data were analyzed by using SPSS program for descriptive statistics, Pearson's correlation coefficients, t-test, ANOVA. Results: Subjects showed the mild level of fatigue and slightly high level of daily living activities. They also showed a negative relationship between fatigue and daily living activities. Conclusion: It is necessary to develop nursing intervention program to reduce the level of fatigue for improving the level of daily living activities in patients with chronic liver disease.
박종대,이유희,Park, Jong-Dae,Lee, You-Hui 한국생약학회 1999 생약학회지 Vol.30 No.2
In our continuing search for new antineoplastic agents from natural products, one hundred and thirty-five herbal drugs were extracted with petroleum ether/ether (1:1), ethyl acetate and methyl alcohol, successively and their cytotoxicities were evaluated against A549 (human lung carcinoma) and SK-OV-3(human ovary adenocarcinoma) cell lines. Among them, fifteen kinds of ether extracts, eighteen kinds of ethyl acetate extracts and seven kinds of methanol extracts showed significant cytotoxic activities (above 70% inhibition) against A549 cell lines at a concentration of $40\;{\mu}g/ml,$ while ten kinds of ether extracts, thirteen kinds of ethyl acetate extracts and six kinds of methanol extracts demonstrated significant cytotoxic activities against SK-OV-3 cell lines at the above same concentration.
김혜영,이유희,김신일 ( Hye Young Kim ( Jun ),You Hui Lee,Shin Il Kim ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.2
Based on the antioxidant activity of panaxytriol, its effect on glutathione peroxidase activity, ornithine decarboxylase induction in mouse epidermis and 3-methylcholanthrene (MCA)induced skin tumorigenesis were investigated. The effect of panaxytriol on croton oil-induced edema of mouse ears was also investigated. As results, panaxytriol significantly prevented decrease in gluthathione peroxidase activity and ornithine decarboxylase induction caused by croton oil. In addition, panaxytriol significantly inhibited croton oil-induced edema. In BALB/c mice receiving MCA, panaxytriol afforded protection by delaying the subsequent development of skin tumors. It is suggested that panaxytriol have potential for modifying the risk of skin tumorigenecity, which may be supported in part by protection from free radical-induced reactions.
박종대,이유희,백남인,김신일,안병준,Park, Jong-Dae,Lee, You-Hui,Baek, Nam-In,Kim, Shin-Il,Ahn, Byung-Zun 한국생약학회 1995 생약학회지 Vol.26 No.4
Through bioassay-guided separation of the chemical constituents from the heartwood of Dalbergia odorifera, an 2'-O-methoxyisoliquiritigenin(1) was isolated as cytotoxic principle. 1 showed potent cytotoxic activity against the three kinds of human cancer cell lines (A-549, SK-MEL-2 and SK-OV-3) with similar activity to 5-Fluorouracil.
유영진,이유희,김영숙,박종대,김신일,Yoo, Young-Jin,Lee, You-Hui,Kim, Young-Sook,Park, Jong-Dae,Kim, Shin-Il 한국생약학회 1997 생약학회지 Vol.28 No.4
As a part of searching for new antitumor agents from natural products, 94 kinds of Chinese plants were extracted with petroleum ether/ether (1:1), ethyl acetate and methanol, successively and their cytotoxicities were evaluated against A549 (human lung carcinoma) cell line. Among them, six kinds of ether extracts, seven kinds of ethyl acetate extracts and one kind of methanol extracts showed significant cytotoxic activities (above 70% inhibition) at a concentration of $50\;{\mu}g/ml$. These results surest that they may be involved in natural sources with possible anticancer activities.
고려인삼의 간독성에 대한 보호성분 : 과산화지질 형성에 미치는 영향
김헤영,이유희,김신일 ( Hye Young Kim,You Hui Lee,Shin Il Kim ) 생화학분자생물학회 1989 BMB Reports Vol.22 No.1
Three polyacetylene compounds, panaxydol, panaxynol and panaxytriol were isolated from Korean ginseng and their inhibitory effects on lipid peroxidation in vivo and in vitro were investigated. Lipid peroxide levels both in serum and liver microsome and serum enzyme (GOT, GPT, LDH) activities of CCl₄ -administered rats were determined after pretreatment of polyacetylenes. Hepatic microsomal cytochrome P-450-dependent monooxygenases were also measured to investigate the mechanism of action. Enzymatic (paraquat/NADPH) and nonenzymatic (ascorbate/Fe^(+2) systems were used for in vitro lipid peroxidation. As results, polyacetylene compounds inhibited liver lipid peroxidation and panaxynol lowered serum lipid peroxide levels caused by CC1₄. Polyacetylene pretreatment prevented leakage of LDH to serum but elevated GOT and GPT levels were not changed. CCl₄ caused marked losses in cytochrome P-450 and reduced the activities of aniline hydroxylase and aminopyrine demethylase. Polyacetylene treatment without CCl₄ induced aminopyrine demethylase and panaxydol and panaxynol induced aniline hydroxylase while the content of cytochrome P-450 were not affected. In vitro microsomal lipid peroxidation was inhibited by polyacetylenes and DL-α-tocopherol in a dose-dependent manner. The results demonstrate that polyacetylenes protected against hepatotoxicity of CCl₄ by inhibiting lipid peroxidation in vivo and in vitro possibly through the mechanism of direct action on liver microsomes.