가족부양자의 일반적 특성에 따른 사회적지지, 건강관련 삶의 질 및 부양부담감 간의 관계

성미라(Mi-Ra Sung),정기정(Gi-Jung Jung) 한국의료정보교육협회 2016 보건의료생명과학논문지 Vol.4 No.2

본 연구의 목적은 지역사회에 거주하고 있는 치매환자 가족부양자의 일반적 특성에 따른 사회적지지, 건강관련 삶의 질 및 부양부담간의 관계를 확인하기 위함이다. 연구방법: 본 연구는 치매환자 가족부양자 140명을 대상으로 시행되었다. 치매환자 가족부양자의 사회적지지, 건강관련 삶의 질 및 부양부담감 측정은 구조화된 설문지를 사용하였고, 수집된 자료는 t-test, ANOVA, 상관관계분석을 시행하였다. 연구결과: 치매환자 가족부양자의 직업유무 사회적지지 사이에는 통계적으로 유의한 부적 상관관계가 있는 것으로 나타났다(ρ=-.26, p=.002). 치매가족부양자의 연령(r=.30, p=<.001)과 직업유무(ρ=.19, p=.025)는 건강관련 삶의 질과 통계적으로 유의한 정적상관계가 있는 것으로 나타났고, 치매가족부양자의 월평균소득은 건강관련 삶의 질과 통계적으로 유의한 부적상관관계가 있는 것으로 나타났다(ρ=-.20, p=.016). 치매가족부양자의 성별(ρ=-.28, p=.001), 진단시기(ρ=-.22, p=.009) 및 월평균소득(ρ=-.20, p=.020)은 부양부담감과 통계적으로 유의한 부적상관관계가 있는 것으로 나타났다. 결론: 치매환자 가족부양자의 일반적 특성을 고려하여 건강관련 삶의 질과 사회적 지지를 증가시키고 부양부담감을 줄일 수 있는 프로그램 개발이 필요하다. The purpose of this study was to describe status of social support, Health-related quality of life and caregiving burden in family caregivers of persons with dementia living at community-dwelling. Methods: This study included 140 family caregivers of persons with dementia. Social support, Health-related quality of life and caregiving burden are measured structured questionnaires each. Data were collected using structured questionnaires and analyzed using t-test, ANOVA and correlation analysis Results: There was statistically significant negative correlation between social support and job(ρ=-.26, p=.002). Health-related quality of life with age (r=.30, p=<.001) and job(ρ=.19, p=.025) were statistically significant positive correlation relationship, and is a significant monthly income there was statistically significant negative correlation(ρ=-.20, p=.016). There was statistically significant negative correlation between caregiving burden and gender(ρ=-.28, p=.001), diagnosis after recognition(ρ=-.22, p=.009) and monthly income(ρ=-.20, p=.020). Conclusion: The results of this study suggest that programs be developed to increase perceived health status, social support and to decrease caregiving burden for family caregivers.

재가 치매 노인환자를 돌보는 가족원의 극복 경험

성미라(Sung, Mi Ra),이명선(Yi, Myungsun),이동영(Lee, Dong Young),장혜영(Jang, Hye Young) 한국간호과학회 2013 Journal of Korean Academy of Nursing Vol.43 No.3

Purpose: The purpose of the study was to understand and describe the overcoming experiences of family members caring for elderly patients with dementia at home. Methods: Data came from autobiographies on the overcoming experiences of caregiving from 31 participants, who had submitted the autobiographies to a public contest held by the Seoul Metropolitan Center for Dementia in 2012. Data were analyzed using qualitative content analysis. Results: Four overcoming stages emerged from the analysis: confronting stage; challenging stage; integrating stage; and transcendental stage, representing transformation of experiences from frustration and suffering to happiness and new hope in life. The confronting stage illustrates severe negative feelings and exhaustion occurring after the diagnosis of dementia. The challenging stage signifies major driving forces in taking good care of their patients. It includes tender loving memories about the patients as well as family and social supports. The integrating stage shows genuine empathy for the patients’ situation and the happiness of ‘here and now’, while the transcendental stage represents new hope in the future. Conclusion: Health professionals need to support caregivers to find true meaning of caring and happiness in everyday life, while providing specific information on dementia care and relieving various negative feelings.

생쥐 초기 배아에서 분리한 할구를 이용한 배아줄기세포주 확립

임천규,성지혜,최혜원,조재원,신미라,전진현,Lim, Chun Kyu,Sung, Ji Hye,Choi, Hye Won,Cho, Jae Won,Shin, Mi Ra,Jun, Jin Hyun 대한생식의학회 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.1

목 적: 본 연구에서는 착상전 생쥐 배아에서 분리한 할구를 이용하여 배아줄기세포주를 확립하고 그 효용성과 특성을 살펴보고자 하였다. 연구방법: 생쥐 (C57BL/6J)의 2- 또는 4-세포기 배아에서 투명대를 제거하고 할구를 분리하여 지지세포와 공동배양한 후 할구로부터 형성된 내세포괴를 분리하여 계대배양을 실시하였다. 계대배양 중인 세포주의 특성을 확인하기 위해 alkaline phosphatase 활성도와 표지 인자 및 관련 유전자 발현을 세포면역화학적 염색과 RT-PCR 방법으로 살펴보았다. 또한, 계대배양 중인 배아줄기 세포주의 염색체 분석을 실시하였다. 결 과: 전체적으로 2-세포기에서 분리한 할구와 4-세포기에서 분리한 할구에서 각각 3.0% (1/33)와 4.0% (1/25)의 효율로 배아줄기세포주를 확립할 수 있었다. 이는 4-세포기의 배아를 사용하였을 때의 16.7% (5/30)에 비해 현저하게 낮았다. 분리된 할구로부터 확립된 배아줄기세포주에서 SSEA-l 과 Oct-4의 발현을 관찰하였고, 이들에서 분화된 배아체에서 삼배엽성 분화 관련 유전자들의 발현도 확인할 수 있었다. 결 론: 본 연구에서는 동물모델을 이용하여 착상전 초기 배아에서 분리한 할구를 이용하여 배이줄기세포를 확립할 수 있음을 확인하였다. 지속적인 관련 연구를 통해 인간의 체외수정 및 배아이식술에서 배아의 파괴 또는 발생 능력에 손상을 주지 않고 새로운 인간 배아줄기세포주를 생산할 수 있는 방법을 개발하고 실용화할 수 있을 것으로 사료된다. Objective: The aim of this study was to investigate whether embryonic stem (ES) cells can be established from isolated blastomeres of mouse embryos. Methods: Blastomeres were separated from mouse (C57Bl/6J) 2- or 4-cell embryos. Isolated blastomeres or whole 4-cell embryos were co-cultured with mitosis-arrested STO feeder cells in DMEM supplemented with recombinant murine leukemia inhibitory factor and ES-qualified fetal bovine serum. After the tentative ES cell lines were maintained from isolated blastomeres or whole embryos, some of them were frozen and the others were sub-cultured continually. Characteristics of tentative ES cell lines as were evaluated for specific genes expressions with immunocytochemistry and RT-PCR. Results: One ES cell line (3.0%) was established from isolated blastomere of 2-cell embryo and one cell line (4.0%) from isolated two blastomeres of 4-cell embryo. And five cell lines (16.7%) were established from whole 4-cell embryos. Both cell lines from isolated blastomere and whole embryo expressed mouse ES cell specific markers such as SSEA-1, Oct-4 and alkaline phosphatase. Marker genes of three germ layers were expressed from embryoid bodies of both cell lines. Conclusion: This study suggests that mouse ES cells could be established from isolated blastomeres, although the efficiency is lower than whole embryos. This animal model could be applied to establishment of autologous human ES cells from biopsied blastomeres of preimplantation embryos in human IVF-ET program.

경도인지장애노인과 정상노인의 인구학적 특성, 동반질환 및 건강습관 비교

박명화(Park, Myonghwa),성미라(Sung, Mi Ra),김선경(Kim, Sun Kyung),이동영(Lee, Dong Young) 한국간호과학회 2014 Journal of Korean Academy of Nursing Vol.44 No.4

Purpose: This study was done to compare demographic characteristics, comorbidity, and health habits of elders with mild cognitive impairment (MCI) and elders with cognitively normal function (CNF). Methods: Secondary data analysis was conducted using data from the Database of the Seoul Dementia Management Project for 5,773 adults age 60 and above. Results: The MCI group showed an older age distribution, but there was no significant education difference between the two groups. Elders with MCI had more diabetes and stroke than elders with CNF. In subgroups, the same findings were observed in women, but not in men. While more men with MCI had hypertension compared to men with CNF, there was no significant difference in hypertension between the two groups for women. Elders with MCI, men in particular, had a lower prevalence of obesity than men with CNF. MCI individuals did less exercise compared to individuals with CNF. While there were no significant differences in alcohol consumption and smoking between MCI and CNF groups, the over 80’s subgroup with MCI reported more alcohol consumption. Conclusion: Findings from this study could be helpful in designing communitybased dementia prevention programs and health policies to reduce the prevalence of dementia or related cognitive impairments.

간호리더십 함양을 위한 학습성과 평가체계 연구

정희영(Heeyoung Jung),표은영(Eun Young Pyo),성미라(Mi Ra Sung),최은진(Eun-Jin Choi),박소영(So Young Park) 한국간호연구학회 2024 한국간호연구학회지 Vol.8 No.1

요양보호사의 치매관련 지식 및 태도에 관한 연구

김경애(Kyeong Ae Kim),김경아(Kyoung Ah Kim),성미라(Mi Ra Sung) 한국케어매니지먼트학회 2011 한국케어매니지먼트연구 Vol.6 No.-

본 연구의 목적은 치매전문교육을 받은 치매관련시설 종사자 중 요양보호사의 치매 지식과 태도의 관계 및 태도에 미치는 영향요인을 확인하고자 함이다. 연구대상자는 서울시에 위치한 치매시설 종사자 중 서울특별시치매센터에서 치매교육을 받은 요양보호사를 대상으로 하였다. 자료 분석은 수료자 71명 중 설문에 응답한 47명을 대상으로 하였다. 각 연구대상자는 노화 및 치매와 관련된 진단, 위험인자, 예방, 인지재활치료, 간호, 영양, 윤리문제, 가족상담, 사례관리 등을 포함한 26시간의 교육을 수료하였다. 본 연구의 결과는 다음과 같다. 치매노인에 대한 지식정도는 총 16문항으로 전체 지식평균 12.19로 나타났다. 대상자의 치매노인에 대한 태도정도는 5점 중 평균 4.21로 나타났다. 치매노인에 대한 지식과 태도의 상관관계는 전체지식보다 질환지식이 높을수록 긍정적인 태도를 보이는 경향이었으며 통계적으로 유의하였다(r=.369, p=.011). 다중회귀분석을 한 결과, 수정된 결정계수는 .122로 설명력은 12.2%였고, 요양보호사의 태도에 영향을 미치는 주요 요인으로 돌봄 시간이 증가할수록 태도는 감소하고 지식정도가 높을수록 태도도 증가함을 확인하였다. This study has been conducted for the purpose of identifying the relationship of careworkers' knowledge of the patients who had dementia and their attitude toward them and analysing factors affecting attitudes in certified geriatric careworker. The subjects were collected from dementia education in Seoul Dementia Center. The data were gathered from June 26th to July 3rd 2010 through questionnaires. The collected data were analyzed using Win SPSS 12.0 program. Careworkers' average score they got from their knowledge about the patients who had dementia was 12.19(Total 16 items). Their score they got from their attitude toward their senile patients who had dementia was 4.21. So the relationship between these two: as the knowledge about the patients who had the dementia increased, they tended to have higher positive attitude toward their patients: this was statistically very significant(r=.369, p=.011). As a result of multiple regression analysis shows, the major factors that could influence the attitude of caretakers were length of their caring time and their knowledge about the patients who had dementia. As their caring time lengthens their attitude becomes worsening. In the meantime while their knowledge about the patients who had dementia deepens, their attitude becomes better.

60세 이상 성인의 치매 관련 영향요인

김성민(Kim, Seong Min),서현주(Seo, Hyun-Ju),성미라(Sung, Mi Ra) 한국간호과학회 2014 Journal of Korean Academy of Nursing Vol.44 No.4

Purpose: This study was done to examine the association between body mass index (BMI) and any type of clinical dementia. Methods: Participants were 60,321 people over 60 years of age enrolled in the Seoul Dementia Management Project in 2011. K-MMSE was used to classify participants as having a cognitive impairment and the Clinical Dementia Rating or DSM-IV by psychiatrists or neurologists to determine whether participants were in the dementia group or the non-dementia group. Descriptive statistics, chi-square test, and binary logistic regression analysis were performed. Results: In the univariate analysis, age, education level, living with spouse, BMI, alcohol consumption, and exercise were significantly associated with dementia. In multivariable analysis, increasing age was positively associated with dementia, and educational level was negatively associated with dementia. The exercise group had a lower prevalence of dementia than the non-exercise group. The odds ratio of dementia in the over-weight and obese groups compared to the normal group was 0.85 (95% CI 0.60, 0.98) and 0.64 (95%CI 0.46, 0.75), respectively. Conclusion: Results indicate that dementia is negatively associated with increasing BMI in people aged 60 years or older, but a prospective cohort study is needed to elucidate the causal effect relationship between BMI and dementia.