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포스터 발표 : 막성 사구체신염 환자에서 스테로이드 치료 중 발생한 Kaposi 육종 치험 1예
이호철 ( Lee Ho Cheol ),김향 ( Kim Hyang ),박정식 ( Park Jeong Sig ),이규백 ( Lee Gyu Baeg ),유재학 ( Yu Jae Hag ),박문향 ( Park Mun Hyang ) 대한신장학회 2002 춘계학술대회 초록집 Vol.21 No.1
Membranous glomerulonephropathy is a common cause of nephrotoc sundrome in adults. Kaposi sarcoma is a well-known entity with distinct clinical forms such as nodular cutaneous lesions, generalized lymphadenopathy and visceral involvement. Incidence of Kaposi sarcoma is greater in patients with immunosuppression, particularly those having undergone renal transplantation, but also in patients with other underlying disorders treated with immunosuppressive therapy, notably, corticosteroids. We present a case of Kaposi sarcoma in patient with membranous glomerulopathy during corticosteroid therapy. A 49-year-old man was admitted with a complain of facial and leg edema, 5-kg weight gain for 1 month and foamy urine. Kidney biopsy showed membranous glomerulopathy. We started corticosteroid therapy to the patient. Two month later, his 24 hrurinary protein was decreased to 2.1 g/day. But, the well defined, various-sized, purple-colored papules and plaque appeared on the both hands and feet. He underwent skin biopsy, which revealed abnormally proliferated and dilated vessels, vascular slits, spindle-shaped cells and extravasated erythrocytes in the dermis. The findings were in accordance with Kaposi sarcoma. So he received cryotherapy with discontinuing corticosteroid. Four months after cryotherapy, skin lesions were cleared leaving slight hypopigmentation and amount of proteinuria was preserved without definite aggravation.
신증후군의 재발과 함께 발생된 관상동맥 혈전증에 의한 급성 심근경색
백은기 ( Baeg Eun Gi ),박정우 ( Park Jeong U ),김영남 ( Kim Yeong Nam ),문인성 ( Mun In Seong ),이현희 ( Lee Hyeon Hui ),이준승 ( Lee Jun Seung ),정우경 ( Jeong U Gyeong ),신익균 ( Sin Ig Gyun ),박문향 ( Park Mun Hyang ),이종호 ( 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5
Vascular thrombosis is one of the most serious complications in patients with nephrotic syndrome. but thrombosis occurs mainly in venous system. Ar terial thrombosis is much less common and coronary artery thrombosis is rarely reported worldwide. We experienced a case of an acute myocardial infarction due to coronary artery thrombosis in a young male with minimal change disease during nephrotic relapse. This 35 year-old male was diagnosed to have minimal change nephrotic syndrome 15 years before admission. Two days before admission, he was found to have heavy proteinuria and edema which led to impression of relapse of nephrotic syndrome. Acute myocardial infarction was developed one day before admission and emergency thrombolytic therapy was performed. After admission, coronary angiography was performed and multiple thrombi were identified in distal left anterior descending artery without marked atherosclerotic changes. The formation of intracoronary thrombi in this patient appeared to be due to the hypercoagulable state associated with the relapse of nephrotic syndrome.
유선진 ( Yu Seon Jin ),정성진 ( Jeong Seong Jin ),김일 ( Kim Il ),박환철 ( Park Hwan Cheol ),윤여욱 ( Yun Yeo Ug ),이창화 ( Lee Chang Hwa ),강경원 ( Kang Gyeong Won ),강종명 ( Kang Jong Myeong ),박문향 ( Park Mun Hyang ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.6
The overall incidence of malignancy in a renal transplanted patient is 3 to 5 times higher compared with general population. We report a very rare case of multiple leiomyoma originated from lung after renal transplantation. 33-year-old male underwent renal transplantation in November, 1989. A 5 mm sized pulmonary nodule was found in the left lower lobe incidentally in March, 2001. The size of pulmonary nodule increased and same lesion was found on the opposite side of the lung on chest roentgenogram after one year, so we proceeded with computed tomography of the chest. Variable sized multiple nodules in the whole lung field were noted, which were thought be metastatic lesions, and for detection of the primary site of malignancy, further study including esophagogastroduodenoscope, colon study, abdominal ultrasound, abdominal CT, bone scan and tumor marker were checked, but there was no evidence of primary cancer. After open lung biopsy low malignant potential smooth muscle tumor was noted, and Epstein-barr virus (EBV) DNA was detected. The patient had been maintained on immunosuppressive therapy with cyclosporine and mycophenolate mofetil (MMF), and after the diagnosis of leiomyoma administration of MMF was stoped, and cyclosporine dosage was reduced. With the reduction of immunosuppressants, intravenous immunoglobulin trial was done for the first cycle, but the efficacy of treatment is not clear. (Korean J Nephrol 2003;22(6):767-772)
일반연제 발표 : Baxter 연구비 결과보고 ; N-acetylcysteine 투여가 Adriamycin 신증 백서의 사구체 Laminin과 Cytokine 발현에 미치는 영향
한상웅 ( Han Sang Ung ),유준호 ( Yu Jun Ho ),박일규 ( Park Il Gyu ),백승삼 ( Baeg Seung Sam ),박문향 ( Park Mun Hyang ),정호삼 ( Jeong Ho Sam ),김수완 ( Kim Su Wan ),이종은 ( Lee Jong Eun ),김호중 ( Kim Ho Jung ) 대한신장학회 2002 춘계학술대회 초록집 Vol.21 No.1