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2009 Influenza A H1N1 감염 중 소아 중증 환자에 대한 고용량 Oseltamivir 투여 효과
조현석 ( Hyun Seok Cho ),민세라 ( Se Ra Min ),이준호 ( Joon Ho Lee ),안성연 ( Sung Yeun Ahn ),이현수 ( Hyeon Soo Lee ),양정희 ( Jeong Hee Yang ),김자경 ( Ja Kyoung Kim ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.1
Purpose: We aimed to evaluate the use and safety of double dose oseltamivir for patients manifesting severe respiratory symptoms or showing no improvement of clinical symptoms after 72 hours’ treatment with the usual oseltamivir dosage. Methods: We analyzed the clinical features of 2009 influenza A H1N1 inpatients who had been admitted to a university hospital’s Department of Pediatrics between August 2009 and January 2010. The Influenza A H1N1 diagnoses were confirmed by real-time reverse transcriptase polymerase chain reaction. Results: The study participants numbered 157 (mean age, 5.0 years; male-to-female ratio, 1.1:1). Among them, twenty (mean age, 5.2 years) were administered double dose oseltamivir. This double dose group showed higher peak body temperatures and more abnormal radiologic results than the other, usual-dose group. The mean time duration between high fever and afebrile status after initiation of double-dose oseltamivir administration was 2.1 days, whereas that within the usual-dose group was 1.7 days. There were no adverse effects in the patients treated with double-dose oseltamivir. Conclusion: Double-dose oseltamivir was well tolerated in patients with severe 2009 influenza A H1N1 infection. (Allergy Asthma Respir Dis 2014;2:64-69)
신생아에서 발생한 혈관종을 동반한 선천성 거대 멜라닌세포 모반 1례
조현석 ( Hyun Seok Cho ),추영광 ( Young Kwang Choo ),민세라 ( Se Ra Min ),이상열 ( Sang Yeol Lee ),이승구 ( Seung Gu Lee ),이현수 ( Hyeon Soo Lee ) 대한주산의학회 2012 Perinatology Vol.23 No.2
Giant congenital melanocytic nevi are very rare skin lesions with an estimated prevalence of 1 in 20,000 live births, and have high risk of malignant melanoma development and leptomeningeal melanocytosis. Hence, its early and exact diagnosis in the neonatal period is important and essential. Only seven cases of giant congenital melanocytic nevi have been reported in Korea, of which none of the cases were associated with hemangioma. Herein, the authors describe a case of giant congenital melanocytic nevi with huge hemangioma with the patho logic findings that exhibited benign and provide a literature review.