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RALS에 장착한 Ir-192 선원의 강도측정에 대한 고찰
문언철,Moon, Un-Chull 대한방사선치료학회 1994 大韓放射線治療技術學會誌 Vol.6 No.1
In the past, brachytherapy was carried out mostly with radium or radon sources. Currently. use of artificially produced radionuclially produced radionuclides such as $^{137}Cs,\;^{192}Ir,\;^{198}Au,\;and\;^{125}I$ is rapidly increasing. Although electrons are often used as an alternative to interstitial implants, brachytherapy continues to remain an important mode of therapy, either alone or combined with external beam. The National Council on Radiation Protection and Measurements(NCRP) recommends that the strength of any ${\gamma}$ emitter should be specified directly in terms of exposure rate in air at a specified distance such as 1m. The air kerma strength is defined as the product of air kerma rate in 'free space' and the square of the disrance of the calibration point from the source center along the perpendicular bisector, i. e., $S_k=K_L{\times}L^2$. Where $S_K$ is the the air kerma strength and K is the air kerma rate at a specified distance L. (usually 1m). Recommended units for all kerma strength are ${\mu}Gym^{2}h^{-1}$.
ML-6M LINAC에 장착한 Radiosurgery Cone의 Beam 특성에 대한 고찰
문언철,김현진,김영석,Moon, Un-Chull,Kim, Hyun-Jin,Kim, Young-Suk 대한방사선치료학회 1995 大韓放射線治療技術學會誌 Vol.7 No.1
The radiosurgery treatment is one time, non surgical approach to the treatment of patients with intracranial disorders whose conditions would be difficult or dangerous to treat with conventional sugical procedures. The LINAC based radiosurgery is based on the combination of multiple isocentric arc irradiation with small fields centered in the stereotactic target. The absorption of the beam in a tissue equivalent medium, such as water, as well as the uniformity, or profile, of the beam must be precisely documented. The beam characteristics and dosimetric measurememts of the 6MV X-ray beam from a ML-6M linear accelerator are examined. The percent depth dose (PDD) and beam profile (including flatness, symmetry and penumbra) is calibrated with the radiosurgery cone in water phantom. The cone is made of lead which size is from $10{\times}10mm{\phi}$ to $30{\times}30mm{\phi}$ All of these dosimetric measurements sufficiently characterized the beam to permit safe clinical use.
PTW-LinaCheck 측정기의 선량 특성과 일일 출력측정 응용에 관한 연구
정동혁,이강규,문언철,김현진,김영석,문성록,Jeong, Dong-Hyeok,Lee, Kang-Kyoo,Moon, Un-Chul,Kim, Hyun-Jin,Kim, Young-Seok,Moon, Sun-Rock 한국의학물리학회 2008 의학물리 Vol.19 No.1
본 연구에서는 선형가속기 출력 검출용으로 상용화된 PTW-LinaCheck의 선량 특성을 조사하고 임상적 응용에 관하여 논의하고자 한다. 본 연구에서는 6, 15MV광자선 및 4, 6, 9, 12, 16 MeV전자선에 대하여 측정값의 재현성, 선형성, 선량률 의존성을 조사하였다. 또한 측정값의 오차범위를 조사하기 위하여 일일 점검 시 검출기의 셋업의 기하학적 오차에 의한 측정값의 변화를 조사하였다. 본 측정의 결과로서 일일 측정 시 셋업 오차에 의한 측정값의 변화는 재현성을 포함하여 ${\pm}0.6%$ 이내로 평가되었다. 이 때 선형성과 선량률 의존성에 의한 오차는 무시할 정도였다. 이를 통하여 LinaCheck는 선량 특성과 편리한 셋업의 관점에서 양호한 것으로 결론을 내렸다. 아울러 본 논문에서는 본 검출기를 사용한 60여 일간의 임상적 적용 사례도 제시하였다. In this study, we have investigated the dose characteristics of PTW-LinaCheck designed to detect output of medical LINAC and discussed clinical use of the detector. The reproducibility, linearity, and dose rate dependency of the dosimeter were measured for photons of 6 and 15MV and the electrons of 4, 6, 9, 12, and 16MeV. To know the error ranges of the measured data in daily output measurement, the response variations due to geometrical setup errors were measured. As a result of measurement, the error range from the geometrical setup and the reproducibility was less than ${\pm}0.6%$ for given beam qualities in daily output measurement, where the errors from the linearity and the dose rate dependency were negligible. Finally, we concluded that the LinaCheck dosimeter has a good characteristics in terms of dose and setup convenience in daily output measurement. In addition we have shown an examples of clinical use of this dosimeter for measuring daily output more than 60 days.
본태성 고혈압 및 동맥경화성 질환에서의 Prostacyclin 과 Thromboxane A₂ 혈장농도에 대한 고찰
지영구(Young Koo Jee),한형수(Hyung Soo Han),정문성(Moon Sung Jung),이봉휘(Bong Hwi Lee),김관우(Kwan Woo Kim),문언수(Un Soo Moon),한창순(Chang Soon Han),이홍순(Hong Soon Lee),이학중(Hak Joong Lee) 대한내과학회 1990 대한내과학회지 Vol.39 No.4
N/A The concentrations of the metabolites of prostacyclin and thromboxane A₂ (6-keto-PGF1α and 11-dehydro-TxB2) were measured in essential hypertension and artherosclerotic disease, and the concentrations of metabolites were compared after administration of 100 mg/日, 300 mg/日 and 900 mg/ 日of aspirin. The findings were as follows: 1) The concentrations of 6-keto-PGF1α and 11-dehydro-TxB₂ were significantly higher in the essential hypertension group and artherosclerotic disease group than in the control group (p<0.001). 2) The concentrations of 6-keto-PGF1α and 11-dehydro-TxB₂ were higher in the high cholesterol group (p<0.01, p<0.05, respectively). 3) With aspirin administration, the concenatrations of 6-keto-PGF1α and 11-dehydro-TxB₂ were significantly reduced (about 70% was reduced seven days after administration of aspirin). 4) There were no significant differences in reducing the concentrations of 6-keto-PGF1α and 11-dehydro-TxB₂ between three groups of different dosages of aspirin, 100 mg/日, 300 mg/日, and 900 mg/日 of aspirin. These findings suggest that thromboxane A₂ may contribute to the development or progression of hypertension and artherosclerotic disease. 100 mg/ 日 of aspirin may be used as effective as 300 mg/日 or 900 mg/日 of aspirin in preventing thrombotic events.
정상 및 본태성고혈압 환자에서 미세단백뇨 ( Microalbuminuria ) 에 대한 Enalapril 단독요법의 효과
김진일(Jin Il Kim),박인수(In Soo Park),안리숙(Lee Sook Ahn),박지원(Ji Won Park),윤호중(Ho Joong Youn),정욱성(Wook Sung Chung),김재형(Jae Hyung Kim),문언수(Un Soo Moon),최규보(Kyu Bo Choi),홍순조(Soon Jo Hong) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: Prognosis of essential hypertension has been proven to be majorly depend on the target organ damages(TODs). Renal target organ damage serves about 10% mortality in those essential hypertension. Thus prediction of renal TOD is very important in management of essential hypertension. Urinary microalbumin or microalbumin excretion rate (UAER) is thought to be useful early predictive for the renal TOD in diabetes and hypertension. Approximately 40 percent of essential hypertensive patients has been known to have increased UAER. And angiotensin-converting enzyme inhibitor (ACEi) has thought to be effective in decreasing microalbuminuria. This study was designed to evaluate effectiveness of ACEi(enalapril) on significant microalbuminuria in essential hypertension. Methods: 40 cases (M:F=13:27) were subjected in this study. After 4 weeks wash-out period, 24-hour ambulatory blood pressure monitoring (24-hr ABPM) and subsequent measurement of microalbuminuria in 24-hr urine were performed. After 12 weeks enalapril monotherapy, above examinations were repeated and the results were compared. Depend on initial results of 24-hr ABPM and UAER, the subjects were divided into 2 groups each; normotensive, hypertensive, UAER (above 20 ug/min) and non-UAER(less than 20 ug/min) group. Results. 1) After enalapril monotherapy for 12 weeks, whole-day average blood pressure was decreased significantly in whole subjects(n=40, from 145.68/ 94.92 to 123.55/ 81.50, p=0.0001) as well as in hypertensive group(n = 30, from 155.17/100.13 mm Hg to 126.30/83.70 mmHg, p=0.0001), UAER group(n=16, from 153.94/99.31 mmHg to 125.44/ 81.44 mmHg, p=0.0001) and non UAER group(n =24, from 140.17/92.00 mmHg to 122.29/ 81.54 mmHg, p=0.0006) except in normatensive group (n=10, from 117,20/79.30mmHg to 115.30/74.90 mmHg, p=NS). 2) UAER was significantly diminished in whole subjects( 28.14 30.54 vs 10.65 13.56 g/min, p= 0.0014), also in UAER group (from 54.91 33.36 g /min to 17.02 18.86 g/min, p=0.0004), in non UAEB group( from 10.29 4.95 to 6.40 5.70 g/ min,p = 0.015,n = 24), and in hypertensive group (from 32.09 33.25 g/min to 10.95 14.25 g/min, p = 0.0022), but not in normotensive group(from 16.31 16.46 g/min to 9.75 12.24 g/min, p=0.326). 3) Lipid profiles including total cholesterol, triglyceride and HDL-cholesterol were not changed in all groups. Conclusion; Microalbuminuria can be decreased by the administration of ACEi in essential hypertensives. And further study would be necessary to clarify those mechanisms.