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- 저자 : 노영무(Young Moo Rho) (검색결과 4 건)
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은 나노입자 전극과 패러데이 모트를 이용한 미세유체 피코리터 주입기의 전압효율 상승
노영무 ( Young Moo Noh ),진시형 ( Si Hyung Jin ),정성근 ( Seong Geun Jeong ),김남영 ( Nam Young Kim ),노창현 ( Chang Hyun Rho ),이창수 ( Chang Soo Lee ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.4
본 연구에서는 패러데이 모트를 사용한 기존의 피코리터 주입용 미세유체 칩에 은 나노입자를 이용한 전극을 추가하여 전압을 낮추며 효율을 높이는 실험을 수행하였다. 먼저, 복잡한 제조공정에서 탈피하여 은 나노입자 용액을 한 방울 떨어뜨리는 간단한 과정만으로 미세유체 피코리터 주입기 내에 전극을 제조하였다. 본 개념을 통한 은 나노입자 전극과 패러데이 모트가 통합된 미세유체 칩은 은 나노입자 전극을 사용하지 않는 기존 미세유체 칩의 피코리터 주입 시작 전압인 260 V 보다 낮은 전압인 180 V에서 피코리터 주입이 작동되었다. 또한 미세유체 피코리터 주입기는 피코리터 주입 부피를 7.5 pL부터 27.5 pL까지 정밀하게 조절할 수 있음을 주된 장점으로 하고 있다. 본 미세유체 피코리터 주입기는 미세유체 시스템의 새로운 기능을 설계함으로써 각 연구분야를 탐구할 유용한 플랫폼으로 기대되고 있다. This study presents modified microfluidic picoinjector combined Faraday moat with silver nanoparticle electrode to increase electrical efficiency and fabrication yield. We perform simple dropping procedure of silver nanoparticles near the picoinjection channel, which solve complicate fabrication process of electrode deposition onto the microfluidic picoinjector. Based on this approach, the microfluidic picoinjector can be reliably operated at 180 V while conventional Faraday moat usually have performed above 260 V. Thus, we can reduce the operation voltage and increase safety. Furthermore, the microfluidic picoinjector is able to precisely control injection volume from 7.5 pL to 27.5 pL. We believe that the microfluidic picoinjector will be useful platform for microchemical reaction, biological assay, drug screening, cell culture device, and toxicology.
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한국인에서 심바스타틴의 효과와 부작용 분석을 위한 다기관 공동 임상 연구
박영배 ( Young-Bae Park ),서정돈 ( Jung-Don Seo ),배종화 ( Jong-Hwa Bae ),노영무 ( Young-Moo Rho ),이원로 ( Won-Ro Lee ),손민수 ( Min Soo Son ),채성철 ( Shung-Chull Chae ),김권삼 ( Kwon-Sam Kim ),김권배 ( Kwon Bae Kim ),안정천 ( J 대한내과학회 1999 대한내과학회지 Vol.57 No.5
The aim of this study was to investigate the efficacy of simvastatin to improved lipid profiles in hypercholesterolemic Korean patients. Methods : From 25 hospitals in Korea, 478 hypercholesterolemic patients were enrolled from November 1996 to April 1998. The inclusion criteria was hypercholesterolemia over 240 mg/dl after diet therapy for 1 month or hypercholesterolemia over 220 mg/dl in patients with definite evidence of ischemic heart disease. Simvastatin 10mg was started and doubled up to 40mg if total cholesterol level remained higher than 200 mg/dl at monthly check. Of 478 subjects, 344 patients in whom study protocol was not violated were analyzed. Results : Male to female ratio was 27:73 and 47% of the subjects were in 6th decade. Hypertension, coronary artery disease, and diabetes mellitus were present in 30, 10, and 4% of the subjects. Baseline lipid profile (mean of total cholesterol-LDL-HDL-triglyceride mg/dl) was 274-185-52-188. The dose of simvastatin for 3 months was 10/10/10mg in 61% of subjects, 10/20/20mg in 21%, 10/10/20mg in 7%, and 10/20/40mg in 12%. The change of total cholesterol level(before-4wk-8wk-12wk-withdrawal 4wk) was 274-209- 205-198-250, and the maximal reduction rate was 27%. The change of LDL-cholesterol was 185-123-116-110-159, with maximal reduction rate 39%. The change of HDL-cholesterol was 52-54-56-55-54, with maximal increase rate 9%. The change of tryglyceride was 188-161- 164-162-189, with maximal reduction rate 15%. The value before/after treatment of ApoA1, ApoB, and Lp(a) was 129/129, 138/83, and 9.3/10.7, respectively. The level of LDL-cholesterol at the end of treatment was below 100mg/dl in 36% of subjects, 100-130 in 45%, 130-160 in 16%, and over 160mg/dl in 4%. The reduction rate of LDL-cholesterol was different between subjects whose LDL decreased below 100 and those whose LDL did not decrease below 130mg/dl, which suggests the existence of the individual difference of responsiveness to simvastatin. There were only 3 subjects (0.9%) who showed increase of liver enzyme over 3 times as the upper normal limit. Conclusion: Simvastatin is effective in improving lipid profiles in hypercholesterolemic Korean patients without serious side effects. (Korean. J. Med 57:906-915, 1999)
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洪性澈,盧英茂,徐舜圭 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.3
The measurement of the systolic and diastolic phases of the cardiac cycle by indirect means offers a convinient and noninvasive approach to evaluate changes in cardiac performance and remains one of the simple and reliable method of cardiac evaluation. Since 1973 when Lee studied the intervals of hemodynamic events in the cardiac cycle in healthy Koreans by apexcardiogram, studies on the systolic time intervals in normal subjects, hypertension and thyrotoxicosis have been reported in Korea. However, studies on the cardiac cycle events including both systolic and diastolic intervals are still scanty, and there is no study on the cardiac cycle events in patients with ischemic heart discase in Koreans. The present study was designed to investigate the changes in the intervals of cardiac cycle events in patients with hypertensive heart disease without heart failure, stable angina pectoris and old myocardial infarction without heart failure by nonivasive technique by simultaneous recording of ECG, PCG, ACG and carotid artery pulse with Hewlett-Packard 1514C ECG/Phono system. The results obtained were summarized as follows. 1. The intervals of the cardiac cycle events in normal subjects were presented and compared to those presented by other investigators. The SFP and ET/IVCT ratio were higher in male group. However, there was no difference of the cardiac cycle events between male and female groups in this study. 2. The values of Q-I_(M), IVRT, IVCT, PEP, PEP/LVET ratio and REP were higher and ET were lower in patients with hypertensive heart disease than in normal group. The significance of these changes were discussed. 3. The only change in patients with stable angina pectoris was the prolongation of Q-I_(M) and REP comparing to that of normal group. Difference of the values of PEP, IVCT, PEP/LVET ratio and ET/LVCT ratio in angina group to those of normal group was not significant, which suggested that cardiac performance at rest in patients with stable angina pectoris was within the ranges of normal subjects. 4. The values of Q-I_(M), IVCT, IVRT, PEP and PEP/LVET ratio were higher and ET/IVCT ratio were lower in patients with old myocardial infarction than in normal subjects. The site of infarction did not influence the ranges of intervals and ratios of cardiac cycle phases. 5. Cardiac patients with ECG changes such as hypertensive heart disease and old myocardial infarction showed significant changes in IVCT, IVRT, PEP, PEP/LVET ratio comparing to those of normal subjects, suggesting cardiac preformance was disturbed in these diseases, whereas stable angina pectoris with no ECG changes showed no change of cardiac cycle events, which suggested that there was no significant disturbance in cardiac performance at rest in stable angina pectoris.
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