Tioconazole질연고의 Trichomonas Vaginalis질염 치료효과

김승욱(SW Kim),손영수(YS Son) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.11

Candiada성 질염 치료에 효과적으로 사용되는 tioconazole질 연고의 trichomonas vaginalis 질염에 대한 유효성 여부를 관찰하기 위하여 서울대학교병원 산부인과 외래를 방문한 환자중 wet smear상 원충의 존재가 증명된 30예를 대상으로 1일요법(10예), 2일요법(10예), 3일요법(10예)을 시행하여 치료효과를 판정하여 다음과 같은 결과를 얻었다. 1. 약제에 대한 부작용이나 과민성은 관찰되지 않았다. 2. 환자의 연령분포가 21세부터 69세까지 이었으며, 20대와 40대가 가장 많았고, 다음이 30대의 순이었다. 3. 자각증상은 치료전과 치료후의 비교에서 1일요법군, 2일요법군, 3일요법군 모두 특별한 호전이나 차이를 보이지 않았다. 4. 부인과 검진소견상 치료전과 치료후의 비교에서 1일요법군, 2일요법군, 3일요법군 모두 특별한 호전이나 차이를 보이지 않았다. 5. 치료종료 일주일 후의 재검진시 시행한 wet smear와 배양의 결과는 1일요법군, 2일요법군, 3일요법군 모두에서 양성이었을 뿐아니라 오히려 더 많은 trichomonas vaginalis의 출현이 관찰되었다. 이상의 결과에서 candida성 질염 치료시 효과적으로 사용되는 tioconazole질연고는 trichomonas vaginalis에 의한 질염에는 효과적으로 사용할 수 없으며 임상에서 간혹 관찰되는 candida albicans등과의 복합감염인 경우에도 tioconazole 질연고의 사용은 신중히 고려되어야 할 것으로 사료된다. The aim of this study was to assess the efficacy of 6.5% tioconazole, 4.6g ointment(Gyno-Trosyd , Pfizer) used by the intravaginal route in patients with Trichomonas vaginalis. This study was carried out in 30 patients with microbiologically proven vaginal trichomoniasis at the Department of Obstetrics and Gynecology of Seoul National University Medical College From Dec. 1, 1986 to Apr. 30, 1987. Patients ranged from 21 to 69 years of age with a mean of 34.4years. 30 patients were devided into three groups, eg, one day treatment group(N=10), two days treatment group(N=10), and three days treatment group(N=10). Changes in subjective symptoms and objective infection signs were minimal in all three groups. And also in wet smear & culture examination, there was no negative transformation in all three groups. So the use of tioconazole vaginal ointment in the treatment of trichomoniasis is not recommenable although further studies may be needed for confirmation

16-16 Dimethyl Trans Delta-2 Prostaglandin E1 Methyl Ester 질정의 초기임신중절효과에 관한 연구

김승욱(SW Kim),백원영(WY Paik) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.1

결론 1982년 3월부터 6월까지 서울대학교병원 산부인과에 입원하여 PGE1D질정의 질내투여에 의한 초기임신중절술을 받았던 33예를 임상적으로 조사분석하여 다음과 같은 결과를 얻었다. 1) 년령은 22세에서 42세까지 였으며 25세에서 29세까지가 가장 많았다. 2) 경산회수는 2회가 가장 많았고, 임신주수는 6주에서 12주까지 였으며 6∼8주가 가장 많았다. 3) 투약후 진통유발까지의 평균소요시가은 2.35시간이었다. 4) 투약후 출혈발생까지의 평균소요시간은 3.87시간이었다. 5) 투약후 수태산물만출까지의 평균소요시간은 8.82시간이었다. 6) 투약후 자궁경관개대효과는 투여 3시간후 78.8%에서, 투여 6시간후 93.9%에서 자궁경관이 8mm이상었다. 7) 투약전과 2주후 혈액, 뇨, 간기능검사의 변화는 통계학적으로 유의한 차이가 없었다. 8) 부작용은 소화기계통의 증상이 현저하였으며 13예(39.4%), 구토 7예(21.2%), 또한 통증 4예(12.1%)였고 15예(45.5%)에서는 아무런 통증이 없었다. 9) 성공율은 87.9%로 이 중 완전유산이 78.8%로 26예, 불완전유산이 9.1%로 3예였다. Vaginal suppositories containing the 16-16 dimethyl trans delta-2 Prostaglandin E methyl ester were applied for the induction of abortion in early pregnancy. Thirty three patients were recruited to the study and 5 vaginal suppositories were inserted as high as possible into the posterior fornix of the vagina at intervals of 3 hours. The results were as follows 1. The mean interval between first insertion and onset of lower abdominal pain was 2.35 hours. 2. The mesn lnterval between first insertion and onset of uterine bleeding was 3.87 hours. 3. The mean lnterval between first insertion and expulsion of gestational product was 8.82 hours. 4. Cervical dilatation of 8mm or more was produced in 26 patients(78.8%) and 31 patients (93.9%) by 3 and 6 hours after first insertion respectively. 5. No significant changes were noted in laboratory findings beteen before and 2 weeks after treatment. 6. The most frequent side effect was gastrointestinal disturbance - vomiting in% and diarrhea in 39.4% of the patients. 7. Complete abortion was induced in 78.8% and incomplete abortion in 9.1% of the total patients.

한국인 신생아 체중의 최근 추이에 관한 통계학적 연구

김승욱(SW Kim),조석신(SS Cho) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.12

It has been said that the body weight of the newborn infant was influenced by the various factors; race, climate, sex of the newborn infants, duration of pregnancy, age of mother, parities and nutritional condition and the scoico-economic status of parents. As a first step, authors have tried to obtain the average birth weight of newborns, delivered at the Seoul National University Hospital in relation with their partity and gestational period. The data derived from the delivery room of Department of Obstetrics and Gynecology of Seoul National University Hospital from 1962 to 1966 has been used. The results are as follows; 1) The average body weight of the newborn infants is 3.314gm. 2) The average body weight of the male and female are 3.362gm and 3,262gm respectivly. 3) The data of the average body weight of newborn classified by weeks after L.M.P. shows the increase in body weight to 41 weeks and after that significant increase has not been noted. 4) There is no significant difference between the data of the average body weight grouped by year for five years.

자궁내장치 사용자의 난관에 관한 세균학적 및 조직학적 연구

김승욱(SW Kim),이경희(KH Lee) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.5

Recent report have suggested that intrauterine device (IUD) users may have an increased likelihood of developing salpingitis. A comprehensive study of the bacteriology and histology of the fallopian tube in 40 IUD users and 40 non-IUD users was performed at the time of tubal ligation, to observe if any relationship could be detected between the IUD and salpingitis. The results obtained are summarized as follows. 1. The rate of bacteriological contamnation of fallopian tube was 5% in IUD users and 17.5% in non-IUD users 2. Lactobacillus was the only microorganism cultured from the fallopian tubes in IUD users while severeal microorganisms such as Staphylococcus, Eubacterium, Baterioides, Streptococcus, etc. Including Lactobacillus, were cultured in non-IUD users. 3. In contrast to 27.5% of non-IUD users, 60% of IUD users were found to have histological evidence of salpingitis. 4. There seems to be no correlationship between the positive bacterial culture of the fallopian tube and histological evidence of salpingitis in both IUD and non-IUD users.

자궁조영 X선촬영을 이용한 자궁내장치의 연구

김승욱(SW Kim) 대한산부인과학회 1971 Obstetrics & Gynecology Science Vol.14 No.9

자궁조영 X선촬영을 이용한 자궁내장치의 위치를 유용하게 평가할 수 있었다. Many years have passed since the new plastic intrauterine devices have been widely used, but today little is known about the mechanism of action, the causation fo side effects or the reason for the expulsion. The present study has been undertaken to observe the behavior of a device (Lippes` loop) in the uterine cavity and its possible relationship to the side effects.

자궁내장치 Cu - 7 과 Alza - T 의 피임효과에 관한 임상연구

김승욱(SW Kim) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.12

A clinical study on the contraceptive effectiveness of copper-7 and alza-T intrauterine devices was performed to assess their contraceptive effectiveness in korean women. Devices used in the present study wer Cu-7 and Alza-T which releases 50 micrograms per day of the natural progesteone. A total of 161 Cu-7`s and 193 Alza-T`s were inserted and the total months of use accumulated were 1564 months with Cu-7 and 1798 months with Alza-T during the 12months of study period. life-table analysis of the first segment event rates at the end of first year showed the pregnancy rate to be 1.4 the expulsion rate 4.1, and the removal rate 9.0 per 100 insertions with Cu-7 whereas the same rates obtained with Alza-T were 2.0, 2.3 and 7.0 respectively. Event rates of the both devices were definitely lower than those obtained with inert lippes`s loop in the previous studied and were encouragin. The nature of side-effect commonly observed were spotting bleeding pain, and inncreased vaginal discharge. The incidence of bleeding pain, and increased vaginal discharge oberved in the Cu-7 group were similar to those observed in the Alza-T group. However the incidence of spotting in the Alza-T group was 54.4% whereas the same rate in the Cu-7 group was 31.7% . indicating that the acceptability of the Cu-7 is higher than that of the Alza-T

자궁조경술에 의한 자궁내장치의 연구

김승욱(SW Kim),이용희(YH Lee),박정범(JB Park) 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.10

Many investigators have attemped to explain the mechanism of contraceptive action of intrauterine device and the causation of side effects since the new plastic intrauterine devices have been widely used. Bleeding and pain are the most embarrassing side effects associ- ated with the use of IUD`s and they are the major reasons for discontinuation of use. How- ever, little is known about the causation of these side effects. In the previous study, which was undertaken by one of the authors to observe the beha- vior of a device in the uterine cavity and its possible relationship to the side effects, it was observed that the elongation of the Lippes` loop was the most frequently observed distorsion and this was associated with the occurrence of side effects, particularly with the intermenstrual bleeding. The present study was to investigate the possible relationship between the frequency of side effects and the distorsion or displacement of the device in connection with the shape and size of the uterine cavity. METHOD Two hundred and fourteen women who had Lippes` loop, mostly 27.5mm, were randomly selected from the Family Planning Clinic of Seoul National University Hospital and subjected to the hysterographic examination. All examinations include a 2-film bysterogram. The first film is taken after introducing 2 ml of water boluble HYPAQUE diluted to 2:3 with normal saline. This film shows the device clearly with some of the surrounding cavity of the uterus. Then 5ml of the same solution are added and the second film is taken for outlining the entire cavity. The uterus was always straightened by pulling on the cervix before the X-ray picture was taken. Supported in part by a grant of the International Planned Parenthood Federation

임산부의 임상통계학적 관찰

김승욱(SW Kim),강길원(KW Kang) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.12

A Clinical and statistical study on 1,914 women and their 1,952 new born babies has been carried out with specific reference to groups of women who had received and not received antenatal cares. These 1,914 women had been admitted and delivered their babies at the Seoul National University Hospital during the period from April 1, 1964 to March 31, 1966. Out of these 1,914 women, 927 had received antenatal care and 987 had not received. The number of delivery at Seoul National University Hospital and the rate of receiving antenatal care showed somewhat increasing tendency during the period, and it has been disclosed that the duration of hospitalization was shorter in the antenatal group compared with these who had not received antenatal care. The incidence of obstetrical complications, prenatal and neonatal mortality and still birth rate were remarkably lower in the antenatal group than in non-cared group. Also, the incidence of premature birth and premature death rate showed same tendency. The average homoglobin level during labor was in better condition in the antenatal group than in non-cared group.

정상임신 및 임신중독증에 있어서의 요중 renin activity에 관한 연구

김승욱(SW Kim) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.1

정상임신 및 임신중독증에 있어서의 요중 renin activity에 관한 연구 The etiology of the hypertensive diseases of pregnancy remains obscure. The hypertension, edema and proteinura which characterize there syndromes have been variously attributed to primary abnormalities of sodium, water, and steroid metabolism. Other theories have postulated an abnormal release of pressor materials or toxins from site such as the pituitary, adrenal medulla, fetus, placenta, decidua, or uterus. Particularly the cause of hypertension in toxemic patients is still debated in the studies related to toxemic pregnancy. In this regard, the estimation of plasma renin concentration in such patients is of interest in relation to the suggestion that a raised concentration of renin might lead to an increase in plasma angiotensin which in turn could have a pressor effect. Since angiotensin was synthetized and made available for use, the possibility of its having a pathogenic role in disorders of blood pressure and sodium balance has been investigated. Changes in the blood level, metabolism, or pharmacologic characteristics of angiotensin have been reported in certain cases of hypertension(1,2,3,4,5,6). Toxemia has also received such attention and the plasam renin activity in normal and toxemic pregnancy has been investigated by several workers using classic bioassay. Plasma renin activity has been reported to be elevated during normal pregnancy(7,8,9) and values in toxemic pregnancy were below the mean for normal normotensive pregnant women(10,11). The relationship between renin activity and sodium intake has also been reported in human hypertension(3) and in normal pregnancy(12), and an inverse relation has been demonstrated. However, plasma sodium has not been measured to permit a similar comparison in toxemic pregnancy. Therefore, it would be of interest to determine whether the renin activity is related to plasma sodium concentration in toxemic pregnancy. The present study was performed to determine the plasma renin activity in normal and toxemic pregnancy among Korean women using radioimmunoassay procedure and to observe the possible relationship between renin, sodium, and potassium concentration in normal and toxemic pregnancy.

질상피세포의 핵용적에 대하여

김승욱(SW Kim) 대한산부인과학회 1962 Obstetrics & Gynecology Science Vol.5 No.4

The purpose of this experiment was to measure the nuclear volume of exfoliated normal vaginal epithelial cells using cytologic vaginal smears stained by Papanicolaou`s method. The specimens were obtained from 46 patients who visited Outpatient Department, Ob. & Gyn., SNUH and were free from infectious disease or neo-plastic disease of reproductive organs. At first, the longest and shortest diameter of each cell were measured with the "Zeiss Winkel`s Zeichen Apparatur" attached to microscope, then their nuclear volumes were calculated by Matthias, Lange & Hertl`s formula. The exfoliated vaginal epithelial cell were classified as cornified, intermediate and parabasal cells. Only the cells which stained clearly and had no vacuolation, stippling, cytolysis or karyolysis were selected for the measurement. The results obtained are as follows: 1) The nuclear volume of the cornified cells were ranging from 13.8μ³ to 107.1μ³; the intermediate cells, 66.0μ³;-528μ³; and the parabasal cells, 110.0μ³-1,494.0μ³. 1) The ratio of the nuclear volume of each epithelial layer; Cornified: Intermediate: Parabasal ≒1:4:8 .. pap smear...